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  • 1. Sjöberg, Mats
    et al.
    Almer, S.
    Befrits, R.
    Benoni, C.
    Carlson, M.
    Eriksson, A.
    Friis Liby, I.
    Halfvarson, Jonas
    Hertervig, E.
    Karlén, P.
    Lapidus, A.
    Magnusson, A.
    Midhagen, G.
    Tysk, Curt
    Örebro University, School of Health and Medical Sciences.
    Infliximab som “rescue terapi” vid steroidrefraktärt skov av ulcerös kolit: en retrospektiv uppföljningsstudie2011In: Gastrokuriren, ISSN 1651-0453, Vol. 16, no 29, p. PO-14-PO-14Article in journal (Other academic)
  • 2. Sjöberg, Mats
    et al.
    Almer, S.
    Befrits, R.
    Benoni, C.
    Carlson, M.
    Eriksson, A.
    Friis Liby, I.
    Halfvarson, Jonas
    Hertervig, E.
    Karlén, P.
    Lapidus, A.
    Magnusson, A.
    Midhagen, G.
    Tysk, Curt
    Örebro University, School of Health and Medical Sciences.
    Long-term efficacy of rescue therapy with infliximab in steroid-refractory acute attack of ulcerative colitis2011In: Gut, ISSN 0017-5749, E-ISSN 1468-3288, Vol. 60, no Suppl 3, p. A48-A48Article in journal (Refereed)
  • 3.
    Sjöberg, Mats
    et al.
    Örebro University, School of Health and Medical Sciences.
    Almer, Sven
    Befrits, Ragnar
    Benoni, Cecilia
    Carlson, Marie
    Eriksson, Anders
    Friis-Liby, Ingalill
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences.
    Hertervig, Erik
    Karlen, Per
    Lapidus, Annika B.
    Magnuson, Anders
    Midhagen, Gunnar
    Tysk, Curt
    Örebro University, School of Health and Medical Sciences.
    Infliximab as Rescue Therapy in Steroid-Refractory Acute Ulcerative Colitis: A Retrospective Follow-up Study2011In: Gastroenterology, ISSN 0016-5085, E-ISSN 1528-0012, Vol. 140, no 5, p. S590-S590Article in journal (Other academic)
  • 4.
    Sjöberg, Mats
    et al.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Medicine, Skaraborgs Hospital, Lidköping, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden.
    Tysk, Curt
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden.
    Letter: infliximab in severe ulcerative colitis - is it useful for all patients? Authors' reply2013In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 38, no 11-12, p. 1413-1414Article in journal (Refereed)
  • 5.
    Sjöberg, Mats
    et al.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Skaraborgs Hospital, Lidköping, Sweden.
    Magnuson, A.
    Clinical Epidemiology and Biostatistics Unit, Örebro University Hospital, Örebro, Sweden.
    Bjork, J.
    Department of Gastroenterology and Hepatology, Karolinska University Hospital, Stockholm, Sweden.
    Benoni, C.
    Department of Gastroenterology, Skåne University Hospital, Malmö, Sweden.
    Almer, S.
    Division of Gastroenterology and Hepatology, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
    Friis-Liby, I.
    Division of Gastroenterology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Hertervig, E.
    Department of Gastroenterology, Skåne University Hospital, Lund, Sweden.
    Olsson, M.
    Department of Medicine, NÄL Hospital, Trollhättan, Sweden.
    Karlén, P.
    Division of Gastroenterology, Department of Medicine, South Hospital, Stockholm, Sweden.
    Eriksson, A.
    Division of Gastroenterology, Department of Internal Medicine and Geriatrics, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Midhagen, G.
    Skaraborgs Hospital, Lidköping, Sweden.
    Carlson, M.
    Department of Medical Sciences, Gastroenterology Research Group, University Hospital, Uppsala, Sweden.
    Lapidus, A.
    Department of Gastroenterology, Ersta Hospital, Stockholm, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden.
    Tysk, Curt
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden.
    Infliximab as rescue therapy in hospitalised patients with steroid-refractory acute ulcerative colitis: a long-term follow-up of 211 Swedish patients2013In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 38, no 4, p. 377-387Article in journal (Refereed)
    Abstract [en]

    Background: Rescue therapy with infliximab (IFX) has been proven effective in a steroid-refractory attack of ulcerative colitis (UC). The long-term efficacy is not well described.

    Aim: To present a retrospective study of IFX as rescue therapy in UC. Primary end points were colectomy-free survival at 3 and 12months.

    Methods: In this multicentre study, 211 adult patients hospitalised between 1999 and 2010 received IFX 5mg/kg as rescue therapy due to a steroid-refractory, moderate-to-severe attack of UC. Exclusion criteria were duration of current flare for >12weeks, corticosteroid treatment for >8weeks before hospitalisation, previous IFX therapy or Crohn's disease.

    Results: Probability of colectomy-free survival at 3months was 0.71 (95% CI, 0.64-0.77), at 12months 0.64 (95% CI, 0.57-0.70), at 3years 0.59 (95% CI, 0.52-0.66) and at 5years 0.53 (95% CI, 0.44-0.61). Steroid-free, clinical remission was achieved in 105/211 (50%) and 112/209 (54%) patients at 3 and 12months respectively. Of 75 colectomies during the first year, 48 (64%) were carried out during the first 14days, 13 (17%) on days 15-90 and 14 (19%) between 3 and 12months. There were three (1.4%) deaths during the first 3months.

    Conclusions: Infliximab is an effective rescue treatment, both short- and long-term, in a steroid-refractory attack of UC. Most IFX failures underwent surgery during the first 14days, which calls for studies on how to optimise induction treatment with IFX. Serious complications, including mortality, were rare.

  • 6. Sjöberg, Mats
    et al.
    Walch, A.
    Meshkat, M.
    Gustavsson, A.
    Järnerot, G.
    Vogelsang, H.
    Hertervig, E.
    Novacek, G.
    Friis Liby, I.
    Blomquist, L.
    Angelberger, S.
    Karlén, P.
    Grännö, C.
    Vilien, M.
    Ström, M.
    Verbaan, H.
    Hellström, P. M.
    Magnuson, A.
    Halfvarson, Jonas
    Reinisch, W.
    Tysk, Curt
    Örebro University, School of Health and Medical Sciences.
    Cyclosporin eller infliximab som rescue terapi vid steroidfraktär ulcerös kolit: en retrospective observationsstudie2010In: Gastrokuriren, ISSN 1651-0453, Vol. 15, no 2, p. 34-34Article in journal (Other academic)
  • 7.
    Sjöberg, Mats
    et al.
    Department of Medicine, Skaraborgs hospital, Lidköping, Sweden.
    Walch, Andrea
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.
    Meshkat, Mina
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.
    Gustavsson, Anders
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Järnerot, Gunnar
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Vogelsang, Harald
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.
    Hertervig, Erik
    Department of Gastroenterology, Skåne University Hospital, Lund University, Lund, Sweden.
    Novacek, Gottfried
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.
    Friis-Liby, Ingalill
    Department of Medicine, Division of Gastroenterology, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Blomquist, Lars
    Department of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Stockholm, Sweden.
    Angelberger, Sieglinde
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.
    Karlén, Per
    Department of Medicine, Division of Gastroenterology, South Hospital, Stockholm, Sweden.
    Granno, Christer
    Department of Medicine, Division of Gastroenterology, Ryhov Hospital, Jönköping, Sweden.
    Vilien, Mogens
    Division of Gastroenterology, Hilleroed Hospital, Hilleroed, Denmark.
    Ström, Magnus
    Division of Gastroenterology and Hepatology, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
    Verbaan, Hans
    Department of Gastroenterology, Skåne University Hospital, Malmö, Sweden.
    Hellström, Per M.
    Department of Gastroenterology and Hepatology, Karolinska University Hospital Solna, Stockholm, Sweden.
    Dejaco, Clemens
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.
    Magnuson, Anders
    Clinical epidemiology and biostatistic unit, Örebro University Hospital, Örebro, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Reinisch, Walter
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.
    Tysk, Curt
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Infliximab or cyclosporine as rescue therapy in hospitalized patients with steroid-refractory ulcerative colitis: a retrospective observational study2012In: Inflammatory Bowel Diseases, ISSN 1078-0998, E-ISSN 1536-4844, Vol. 18, no 2, p. 212-218Article in journal (Refereed)
    Abstract [en]

    Background: Cyclosporine (CsA) or infliximab (IFX) are used as rescue therapies in steroid-refractory, severe attacks of ulcerative colitis (UC). There are no data comparing the efficacy of these two alternatives. Methods: Outcome of rescue therapy was retrospectively studied in two cohorts of patients hospitalized due to steroid-refractory moderate to severe UC: 1) a Swedish-Danish cohort (n 49) treated with a single infusion of IFX; 2) an Austrian cohort (n 43) treated with intravenous CsA. After successful rescue therapy, maintenance immunomodulator treatment was given to 27/33 (82%) of IFX patients and to 31/40 (78%) of CsA patients. Endpoints were colectomy-free survival at 3 and 12 months. Kaplan-Meier and Cox regression models were used to evaluate the association between treatment groups and colectomy. Results: At 15 days, colectomy-free survival in the IFX cohort was 36/49 (73%) versus 41/43 (95%) in the CsA cohort (P = 0.005), at 3 months 33/49 (67%) versus 40/43 (93%) (P = 0.002), and at 12 months 28/49 (57%) versus 33/43 (77%) (P = 0.034). After adjusting for potential confounding factors, Cox regression analysis yielded adjusted hazard ratios for risk of colectomy in IFX-treated patients of 11.2 (95% confidence interval [CI] 2.4-53.1, P = 0.002) at 3 months and of 3.0 (95% CI 1.1-8.2, P = 0.030) at 12 months in comparison with CsA-treated patients. There were no opportunistic infections or mortality. Conclusions: Colectomy frequencies were significantly lower after rescue therapy with CsA than with a single infusion of IFX both at 3 and 12 months' follow-up. The superiority of CsA was seen principally during the first 15 days.

  • 8. Zhulina, Yaroslava
    et al.
    Lindberg, E.
    Sjöberg, Mats
    Nyhlin, Nils
    Wickbom, Anna
    Eriksson, C
    Johansson, I.
    van Nieuwenhoven, Michiel A.
    Salén, E.
    Curman, B.
    Yimam, Y.
    Brummer, Robert
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Bohr, J.
    Tysk, Curt
    Örebro University, School of Health and Medical Sciences.
    Halfvarson, Jonas
    Inflammatorisk tarmsjukdom i Örebro 2010: en epidemiologisk uppdatering2011In: Gastrokuriren, ISSN 1651-0453, Vol. 16, no 29, p. PO-10-PO-10Article in journal (Other academic)
1 - 8 of 8
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