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  • 1. Andersson, Kjell
    et al.
    Stridh, Göran
    Örebro universitet, Institutionen för teknik.
    Bodin, Lennart
    Örebro universitet, Institutionen för ekonomi, statistik och informatik.
    Besvär av innemiljön: medicinska och psykologiska mekanismer kan förklara2006Inngår i: Miljöforskning, ISSN 2000-8627, nr 1, s. 20-21Artikkel i tidsskrift (Annet vitenskapelig)
  • 2.
    Arvidsson, Erik
    et al.
    Örebro universitet, Akademin för naturvetenskap och teknik.
    Larsson, Tord
    Örebro universitet, Akademin för naturvetenskap och teknik.
    Stridh, Göran
    Örebro universitet, Akademin för naturvetenskap och teknik.
    Energiförluster i partiellt fuktiga enstegstätade ytterväggskonstruktioner: tema: fasader och fönster2009Inngår i: Bygg & teknik, ISSN 0281-658X, nr 8, s. 28-32Artikkel i tidsskrift (Annet vitenskapelig)
  • 3.
    Bodin, Lennart
    et al.
    Örebro universitet, Handelshögskolan vid Örebro universitet.
    Andersson, K.
    Bonlokke, J. H.
    Molhave, L.
    Kjaergaard, S. K.
    Stridh, Göran
    Juto, J. -E
    Sigsgaard, T.
    Nasal hyperresponders and atopic subjects report different symptom intensity to air quality: a climate chamber study2009Inngår i: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668, Vol. 19, nr 3, s. 218-225Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Short-term exposure to dust and dust added with beta-(1,3)-d-glucan or aldehydes may cause sensory reactions. In random order, we exposed 36 volunteers in a climate chamber to clean air, office dust, dust with glucan, and dust with aldehydes. Three groups of subjects were exposed, eleven were non-atopic with nasal histamine hyperreactivity, 13 were non-atopic, and 12 were atopic. Subjective ratings of symptoms and general health were registered four times during four 6-h exposure sessions. Six symptom intensity indices were constructed. The nasal hyperreactive group had a high and time-dependent increase of mucous membrane irritations, whereas the atopic group had a low and stable rate of irritations with exposure time, close to the reference group (P = 0.02 for differences between the groups with respect to time under exposure for Weak Inflammatory Responses and P = 0.05 for Irritative Body Perception, significance mainly because of the nasal hyperreactive group). Exposure to dust, with or without glucan or aldehydes, showed increased discomfort measured by the index for Constant Indoor Climate, and dust with glucan had a similar effect for the index for Lower Respiratory Effects. For Psychological and Neurological Effects these were dependent on group affiliation, thus preventing a uniform statement of exposure effects for all three investigated groups.Opportunities for identifying persons with high or low sensitivity to low-level exposures are important in preventive medicine and will reduce intra-group variability and thus increase the power of experimental and epidemiological studies searching for correlations between exposures and health effects. The contrast between nasal hyperreactive on one side and atopic and reference subjects on the other side is particularly important. The atopic group indicated a non-homogenous reaction depending on their hyperreactive status, a finding that could be important but needs further confirmation.

  • 4. Bönlökke, J. H.
    et al.
    Stridh, Göran
    Örebro universitet, Institutionen för teknik.
    Sigsgaard, T.
    Kjaergaard, S. K.
    Löfstedt, H.
    Andersson, K.
    Bonefeld-Jörgensen, E. C.
    Jayatissa, M. N.
    Bodin, Lennart
    Örebro universitet, Institutionen för ekonomi, statistik och informatik.
    Juto, J.-E.
    Mölhave, L.
    Upper-airway inflammation in relation to dust spiked with aldehydes or glucan2006Inngår i: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 32, nr 5, s. 374-382Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives Organic dust is associated with adverse effects on human airways. This study was done to investigate whether the addition of β-(1,3)-D glucan or aldehydes to office dust causes enhanced inflammation in human airways.

    Methods Thirty-six volunteers were exposed randomly to clean air, office dust, dust spiked with glucan, and dust spiked with aldehydes. The three dust exposures contained between 332 and 379 µg dust/m3. Spiking with 1 gram of dust was done with 10 milligrams of glucan or 0.1 microliters of aldehydes. Acoustic rhinometry, rhinostereometry, nasal lavage, and lung function tests were applied.

    Results After the exposures to dust spiked with the glucan and aldehydes, the nasal volume decreased (–1.33 and –1.39 cm3 (mean), respectively) when compared with the –0.9 cm3 after clean air or office dust (P=0.036 for a difference in decrease between exposures). After 2–3 hours the aldehyde-spiked dust caused a 0.6-mm swelling of the inferior turbinate, and glucan-spiked dust produced a 0.7-mm swelling (P=0.039 for a difference in the swelling between the four exposures). The preexposure nasal lavage cleaned off the mucosa, and lower cytokine concentrations were found after all of the exposures. For interleukin-8, this decrease in concentration was smaller after the dust exposures spiked with glucan and aldehydes (–2.9 and –25.8 pg/ml, respectively) than after office dust or clean air (–65.9 and –74.1 pg/ml, respectively) (P=0.042). The nasal eosinophil cell concentration increased after exposure to dust spiked with glucan (P=0.045).

    Conclusions β-(1,3)-D glucan and aldehydes in office dust enhance the inflammatory effects of dust on the upper airways

  • 5.
    Frisk, Margot
    et al.
    Örebro universitet, Hälsovetenskapliga institutionen.
    Arvidsson, Helena
    Arbets- och miljömed. kliniken, USÖ.
    Kiviloog, Jaak
    Lungkliniken, USÖ.
    Ivarsson, Ann-Britt
    Örebro universitet, Hälsovetenskapliga institutionen.
    Kamwendo, Kitty
    Örebro universitet, Hälsovetenskapliga institutionen.
    Stridh, Göran
    Örebro universitet, Institutionen för teknik.
    An investigation of the housing environment for persons with asthma and persons without asthma2006Inngår i: Scandinavian Journal of Occupational Therapy, ISSN 1103-8128, E-ISSN 1651-2014, Vol. 13, nr 1, s. 4-12Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Asthma is a chronic disease affected by environmental factors that may increase symptoms that impact on a persons' well-being. An important issue in occupational therapy is to improve the relationship between a person's functional capacity and the physical environment. The aim of the study was to compare the housing environment of persons with asthma (cases, n=49) and persons without asthma (controls, n=48), with regard to building construction and condition, physical, chemical and biological factors, and cleaning routines. A secondary aim was to compare different types of accommodation within cases and controls. A specialist team, including a construction engineer, a biological scientist, and an occupational therapist, conducted the study. Data were collected using protocols, as well as a number of established technical methods from the field of occupational and environmentsl medicine. The primary results showed no major differences in the housing environment between the two groups. However, in individual homes environmental factors at levels that could increase symptoms were identified. When single-familyhouses were compared with multi-family houses, significant differences were found indicating that preventive interventions may be needed in some single-family houses. Further studies are needed to clarify the person-environment relationship for persons with asthma, focusing on their ability to perform daily activities.

  • 6.
    Frisk, Margot L. A.
    et al.
    Örebro universitet, Hälsoakademin.
    Stridh, Göran
    Arbets- och miljömed. kliniken, USÖ.
    Ivarsson, Ann-Britt
    Örebro universitet, Hälsoakademin.
    Kamwendo, Kitty
    Örebro universitet, Hälsoakademin.
    Can a housing environmental index establish associations between indoor risk indicators and clinical tests in persons with asthma?2009Inngår i: International Journal of Environmental Health Research, ISSN 0960-3123, E-ISSN 1369-1619, Vol. 19, nr 6, s. 389-404Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim was to investigate the associations between indoor risk indicators, identified by a Housing Environmental index (HE-index), and clinical tests of lung function, allergy and bronchial hyper-responsiveness (BHR). Forty-nine eligible subjects participated in the investigation. The HE-index was based on national and international guidelines and related to measurements of humidity, temperature, carbon dioxide, formaldehyde, nitrogen dioxide, allergens and occurrence of tobacco smoke and pets. Only 18% of the investigated homes did not have any of the risk indicators. Statistically significant associations were found between exposure to mites and lung function, and to a lesser degree in BHR for subjects living in homes with pets. The cut-off levels in the HE-index were not specifically related to health effects and may therefore have been too high for sensitive persons. Further studies are needed to establish relevant guidelines for the identification of risk indicators in the housing environment for persons with asthma.

  • 7. Mölhave, L.
    et al.
    Kjaergaard, S. K.
    Sigsgaard, T.
    Stridh, Göran
    Örebro universitet, Institutionen för teknik.
    Andersson, K.
    Bodin, Lennart
    Örebro universitet, Institutionen för ekonomi, statistik och informatik.
    Sensitization of occupants of water damaged buildings: does house dust from water damaged buildings cause stronger responses among occupants than dus tfrom buildings without water damage?2006Rapport (Annet vitenskapelig)
  • 8. Mölhave, L.
    et al.
    Sigsgaard, T.
    Kjaergaard, S. K.
    Juto, J. E.
    Andersson, K.
    Stridh, Göran
    Örebro universitet, Institutionen för teknik.
    Bönlökke, J.
    Bonefeld-Jörgensen, E.
    Löfstedt, H.
    Karlsson, T.
    Pan, Z.
    Bodin, Lennart
    Örebro universitet, Institutionen för ekonomi, statistik och informatik.
    Changes in airway mucosal membranes after experimental exposures to dust containing glucan and volatile organic compounds: exposure characterization : final summary report to Formas2006Rapport (Annet vitenskapelig)
  • 9.
    Stridh, Göran
    Örebro universitet, Institutionen för teknik.
    Partiklar och kemi2006Inngår i: Inomhusklimat Örebro 2006, 2006, s. 146-160Konferansepaper (Annet vitenskapelig)
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