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  • 1.
    Carstens, Adam
    et al.
    Örebro University, School of Medical Sciences. Department of Internal Medicine, Ersta Hospital, Stockholm, Sweden; Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Dicksved, Johan
    Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, Uppsala, Sweden.
    Nelson, Ronald
    Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
    Lindqvist, Carl Mårten
    Örebro University, School of Medical Sciences.
    Andreasson, Anna
    Division of Family Medicine and Primary Care, Karolinska Institutet, Huddinge, Sweden.
    Bohr, Johan
    Örebro University, School of Health Sciences. Örebro University Hospital. Department of Gastroenterology.
    Tysk, Curt
    Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Talley, Nicholas J.
    Faculty of Medicine and Health, University of Newcastle, Newcastle, Australia.
    Agréus, Lars
    Division of Family Medicine and Primary Care, Karolinska Institutet, Huddinge, Sweden.
    Engstrand, Lars
    Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Solna, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    The Gut Microbiota in Collagenous Colitis Shares Characteristics With Inflammatory Bowel Disease-Associated Dysbiosis2019In: Clinical and Translational Gastroenterology, ISSN 2155-384X, E-ISSN 2155-384X, Vol. 10, no 7, article id e00065Article in journal (Refereed)
    Abstract [en]

    INTRODUCTION: In inflammatory bowel disease (IBD), an aberrant immune response to gut microbiota is important, but the role of the microbiota in collagenous colitis (CC) is largely unknown. We aimed to characterize the microbiota of patients with CC compared with that of healthy control and patients with IBD.

    METHODS: Fecal samples were collected from patients with CC (n = 29), age- and sex-matched healthy controls (n = 29), patients with Crohn's disease (n = 32), and patients with ulcerative colitis (n = 32). Sequence data were obtained by 454 sequencing of 16S rRNA gene amplicons, and the obtained sequences were subsequently taxonomically classified.

    RESULTS: Analysis of similarity statistics showed a segregation between patients with CC and healthy controls with increasing taxonomic resolution, becoming significant comparing operational taxonomic unit data (P = 0.006). CC had a lower abundance of 10 different taxa. Taxa-specific analyses revealed a consistent lower abundance of several operational taxonomic units belonging to the Ruminococcaceae family in patients with CC, q < 0.05 after false discovery rate correction. Loss of these taxa was seen in patients with CC with active disease and/or corticosteroid treatment only and resembled the findings in patients with IBD.

    DISCUSSION: CC is associated with a specific fecal microbiome seen primarily in patients with active disease or ongoing corticosteroid treatment, whereas the microbiome of CC patients in remission resembled that of healthy controls. Notably, the shift in key taxa, including the Ruminococcaceae family, was also observed in IBD. There may be common mechanisms in the pathogenesis of CC and IBD.

  • 2.
    Carstens, Adam
    et al.
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Department of Internal Medicine, Ersta hospital, Stockholm, Sweden.
    Roos, Annika
    Department of Microbiology, Tumor and Cell biology & Science for Life Laboratory, Karolinska Institute, Solna, Sweden.
    Andreasson, Anna
    Department of Microbiology, Tumor and Cell biology & Science for Life Laboratory, Karolinska Institute, Solna, Sweden; Division for Family Medicine, Karolinska Institute, Stockholm, Sweden; Stress Research Institute, Stockholm University, Stockholm, Sweden.
    Magnuson, Anders
    Clinical Epidemiology and Biostatistics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Agréus, Lars
    Division for Family Medicine, Karolinska Institute, Stockholm, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Engstrand, Lars
    Department of Microbiology, Tumor and Cell biology & Science for Life Laboratory, Karolinska Institute, Solna, Sweden.
    Differential clustering of faecal and mucosa-associated microbiota in healthy individuals2018In: Journal of Digestive Diseases, ISSN 1751-2972, E-ISSN 1751-2980, Vol. 19, no 12, p. 745-752Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Faecal samples are often used to characterise gut microbiota, since they are easily collected. However, whether or not the faecal microbiota differ from the mucosa-associated microbiota remains largely unknown. This may be specifically relevant in conditions that are characterised by complex mucosal microbe-host interactions, such as Crohn's disease. We aimed to determine the degree of agreement between faecal and mucosal microbiota profiles in healthy individuals, using two commonly used collection procedures.

    MATERIAL AND METHODS: The gut microbiota composition of faecal samples (sent at ambient temperature before storage at -70°C) and of colonic biopsies (obtained at endoscopy and immediately stored at -70°C) was determined by sequencing the 16S rRNA gene. Thirty-one randomly selected healthy individuals from the population-based colonoscopy (Popcol) study were included.

    RESULTS: Faecal samples were characterised by a reduced degree of richness (p<0.0001) and diversity (p=0.016), and also differences in several phyla, including a lower relative abundance of Proteobacteria (p<0.0001) and Verrucomicrobia (p=0.008) than in biopsies. Only 3 of 30 individuals had a similar faecal and mucosal microbiota profile, based on weighted UniFrac analysis. A difference in Crohn's disease dysbiosis-associated bacteria was observed, including a lower relative abundance of Faecalibacterium (p=0.004) and a higher relative abundance of Ruminococcus (p=0.001) in faeces than in biopsies.

    CONCLUSIONS: Analysis of faecal samples that have been transported at ambient temperature does not adequately reflect the colonic mucosa-associated microbiota in healthy individuals. These findings have implications for the interpretation of the previous literature, and may be specifically relevant to studies on Crohn's disease.

  • 3.
    Ricanek, P.
    et al.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.
    Rahul, K.
    University of Edinburgh, Edinburgh, United Kingdom.
    Ber, Y.
    Hospital Clinico Universitario, Zaragoza, Spain.
    Vatn, S.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Finnby, L.
    Genetic Analysis AS, Oslo, Norway.
    Lindahl, T.
    Genetic Analysis AS, Oslo, Norway.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences. Örebro University Hospital.
    Carstens, Adam
    Örebro University, School of Medical Sciences.
    Söderholm, J.
    Linköping University, Linköping, Sweden.
    Jahnsen, J.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Gomollon, F.
    Hospital Clinico Universitario, Zaragoza, Spain.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital.
    Satsangi, J.
    University of Edinburgh, Edinburgh, United Kingdom.
    Casen, C.
    Genetic Analysis AS, Oslo, Norway.
    Vatn, M. H.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Microbiota related disease activity and distribution in subgroups of inflammatory bowel disease2017In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 11, no Suppl. 1, p. S483-S484Article in journal (Refereed)
  • 4.
    Vatn, S.
    et al.
    Akershus University Hospital, Akershus, Norway.
    Karlsson, M. C.
    Genetic Analysis AS, Oslo, Norway.
    Carstens, Adam
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Ersta Hospital, Stockholm, Sweden.
    Detlie, T. E.
    Akershus University Hospital, Akershus, Norway; Oslo University, Oslo, Norway.
    Ricanek, P.
    Akershus University Hospital, Akershus, Norway.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Lindquist, C. M.
    Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Jahnsen, J.
    Akershus University Hospital, Akershus, Norway; Oslo University, Oslo, Norway.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Casen, C.
    Genetic Analysis AS, Oslo, Norway.
    Vatn, M. H.
    Oslo University, Oslo, Norway.
    Faecal microbiota in newly diagnosed Crohn's disease and its relation to treatment escalation2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S555-S555Article in journal (Other academic)
  • 5.
    Vatn, S.
    et al.
    Akershus University Hospital, Akershus, Norway.
    Karlsson, M. C.
    Genetic Analysis AS, Oslo, Norway.
    Carstens, Adam
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Ersta Hospital, Stockholm, Sweden.
    Detlie, T. E.
    Akershus University Hospital, Akershus, Norway; Oslo University, Oslo, Norway.
    Ricanek, P.
    Akershus University Hospital, Akershus, Norway.
    Lindquist, C. M.
    Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Jahnsen, J.
    Akershus University Hospital, Akershus, Norway; Oslo University, Oslo, Norway.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Casen, C.
    Genetic Analysis AS, Oslo, Norway.
    Vatn, M. H.
    Oslo University, Oslo, Norway.
    Faecal microbiota in treatment-naive ulcerative colitis and its relation to treatment escalation2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S557-S557Article in journal (Other academic)
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