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  • 1.
    Alexopoulou, Sofia
    et al.
    Örebro University, School of Humanities, Education and Social Sciences.
    Fart, Frida
    Örebro University, School of Medical Sciences.
    Jonsson, Ann-Sofie
    Örebro University, School of Hospitality, Culinary Arts & Meal Science.
    Karni, Liran
    Örebro University, Örebro University School of Business.
    Kenalemang, Lame Maatla
    Örebro University, School of Humanities, Education and Social Sciences.
    Krishna, Sai
    Örebro University, School of Science and Technology.
    Lindblad, Katarina
    Örebro University, School of Music, Theatre and Art.
    Loutfi, Amy
    Örebro University, School of Science and Technology.
    Lundin, Elin
    Örebro University, School of Health Sciences.
    Samzelius, Hanna
    Örebro University, School of Humanities, Education and Social Sciences.
    Schoultz, Magnus
    Örebro University, School of Humanities, Education and Social Sciences.
    Spang, Lisa
    Örebro University, School of Health Sciences.
    Söderman, Annika
    Örebro University, School of Health Sciences.
    Tarum, Janelle
    Örebro University, School of Health Sciences.
    Tsertsidis, Antonios
    Örebro University, Örebro University School of Business.
    Widell, Bettina
    Örebro University, School of Humanities, Education and Social Sciences.
    Nilsson, Kerstin (Editor)
    Örebro University, School of Medical Sciences.
    Successful ageing in an interdisciplinary context: popular science presentations2018Book (Other (popular science, discussion, etc.))
  • 2.
    Ganda Mall, John-Peter
    et al.
    Örebro University, School of Medical Sciences.
    Fart, Frida
    Örebro University, School of Medical Sciences.
    Sabet, Julia
    Örebro University, School of Medical Sciences.
    Lindqvist, Carl-Mårten
    Örebro University, School of Medical Sciences.
    Keita, Åsa V.
    Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
    Brummer, Robert J.
    Örebro University, School of Medical Sciences.
    Schoultz, Ida
    Örebro University, School of Medical Sciences.
    Effects of dietary fibres on indomethacin-induced intestinal permeability in elderly: A randomised placebo controlled parallel clinical trialManuscript (preprint) (Other academic)
  • 3.
    Salihovic, Samira
    et al.
    Örebro University, School of Medical Sciences.
    Dickens, Alex M.
    Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
    Schoultz, Ida
    Örebro University, School of Medical Sciences.
    Fart, Frida
    Örebro University, School of Medical Sciences.
    Sinisalu, Lisanna
    Örebro University, School of Science and Technology.
    Lindeman, Tuomas
    Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Oresic, Matej
    Örebro University, School of Medical Sciences. Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
    Hyötyläinen, Tuulia
    Örebro University, School of Science and Technology.
    Simultaneous determination of perfluoroalkyl substances and bile acids in human serum using ultra-high-performance liquid chromatography-tandem mass spectrometry2019In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650Article in journal (Refereed)
    Abstract [en]

    There is evidence of a positive association between per- and polyfluoroalkyl substances (PFASs) and cholesterol levels in human plasma, which may be due to common reabsorption of PFASs and bile acids (BAs) in the gut. Here we report development and validation of a method that allows simultaneous, quantitative determination of PFASs and BAs in plasma, using 150 μL or 20 μL of sample. The method involves protein precipitation using 96-well plates. The instrumental analysis was performed with ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS), using reverse-phase chromatography, with the ion source operated in negative electrospray mode. The mass spectrometry analysis was carried out using multiple reaction monitoring mode. The method proved to be sensitive, robust, and with sufficient linear range to allow reliable determination of both PFASs and BAs. The method detection limits were between 0.01 and 0.06 ng mL-1 for PFASs and between 0.002 and 0.152 ng mL-1 for BAs, with the exception of glycochenodeoxycholic acid (0.56 ng mL-1). The PFAS measured showed excellent agreement with certified plasma PFAS concentrations in NIST SRM 1957 reference serum. The method was tested on serum samples from 20 healthy individuals. In this proof-of-concept study, we identified significant associations between plasma PFAS and BA levels, which suggests that PFAS may alter the synthesis and/or uptake of BAs.

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