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  • 1.
    Legradi, J. B.
    et al.
    Institute for Environmental Research, Department of Ecosystem Analysis, ABBt–Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany; Environment and Health, VU University, Amsterdam, Netherlands.
    Di Paolo, C.
    Institute for Environmental Research, Department of Ecosystem Analysis, ABBt–Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany.
    Kraak, M. H. S.
    FAME-Freshwater and Marine Ecology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, Netherlands.
    van der Geest, H. G.
    FAME-Freshwater and Marine Ecology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, Netherlands.
    Schymanski, E. L.
    Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg.
    Williams, A. J.
    National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park NC, United States.
    Dingemans, M. M. L.
    KWR Watercycle Research Institute, Nieuwegein, Netherlands.
    Massei, R.
    Department Effect-Directed Analysis, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
    Brack, W.
    Department Effect-Directed Analysis, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
    Cousin, X.
    Ifremer, UMR MARBEC, Laboratoire Adaptation et Adaptabilités des Animaux et des Systèmes, Palavas-les-Flots, France; INRA, UMR GABI, INRA, AgroParisTech, Domaine de Vilvert, Jouy-en-Josas, France.
    Begout, M. -L
    Ifremer, Laboratoire Ressources Halieutiques, L’Houmeau, France.
    van der Oost, R.
    Department of Technology, Research and Engineering, Waternet Institute for the Urban Water Cycle, Amsterdam, Netherlands.
    Carion, A.
    Laboratory of Evolutionary and Adaptive Physiology, Institute of Life, Earth and Environment, University of Namur, Namur, Belgium.
    Suarez-Ulloa, V.
    Laboratory of Evolutionary and Adaptive Physiology, Institute of Life, Earth and Environment, University of Namur, Namur, Belgium.
    Silvestre, F.
    Laboratory of Evolutionary and Adaptive Physiology, Institute of Life, Earth and Environment, University of Namur, Namur, Belgium.
    Escher, B. I.
    Department of Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany; Eberhard Karls University Tübingen, Environmental Toxicology, Center for Applied Geosciences, Tübingen, Germany.
    Engwall, Magnus
    Örebro University, School of Science and Technology.
    Nilén, Greta
    Örebro University, School of Science and Technology.
    Keiter, Steffen
    Örebro University, School of Science and Technology.
    Pollet, D.
    Faculty of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Darmstadt, Germany.
    Waldmann, P.
    Faculty of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Darmstadt, Germany.
    Kienle, C.
    Swiss Centre for Applied Ecotoxicology Eawag-EPFL, Dübendorf, Switzerland.
    Werner, I.
    Swiss Centre for Applied Ecotoxicology Eawag-EPFL, Dübendorf, Switzerland.
    Haigis, A. -C
    Institute for Environmental Research, Department of Ecosystem Analysis, ABBt–Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany.
    Knapen, D.
    Zebrafishlab, Veterinary Physiology and Biochemistry, University of Antwerp, Wilrijk, Belgium.
    Vergauwen, L.
    Zebrafishlab, Veterinary Physiology and Biochemistry, University of Antwerp, Wilrijk, Belgium.
    Spehr, M.
    Institute for Biology II, Department of Chemosensation, RWTH Aachen University, Aachen, Germany.
    Schulz, W.
    Zweckverband Landeswasserversorgung, Langenau, Germany.
    Busch, W.
    Department of Bioanalytical Ecotoxicology, UFZ–Helmholtz Centre for Environmental Research, Leipzig, Germany.
    Leuthold, D.
    Department of Bioanalytical Ecotoxicology, UFZ–Helmholtz Centre for Environmental Research, Leipzig, Germany.
    Scholz, S.
    Department of Bioanalytical Ecotoxicology, UFZ–Helmholtz Centre for Environmental Research, Leipzig, Germany.
    vom Berg, C. M.
    Department of Environmental Toxicology, Swiss Federal Institute of Aquatic Science and Technology, Eawag, Dübendorf, Switzerland.
    Basu, N.
    Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Canada.
    Murphy, C. A.
    Department of Fisheries and Wildlife, Michigan State University, East Lansing, United States.
    Lampert, A.
    Institute of Physiology (Neurophysiology), Aachen, Germany.
    Kuckelkorn, J.
    Section Toxicology of Drinking Water and Swimming Pool Water, Federal Environment Agency (UBA), Bad Elster, Germany.
    Grummt, T.
    Section Toxicology of Drinking Water and Swimming Pool Water, Federal Environment Agency (UBA), Bad Elster, Germany.
    Hollert, H.
    Institute for Environmental Research, Department of Ecosystem Analysis, ABBt–Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany.
    An ecotoxicological view on neurotoxicity assessment2018In: Environmental Sciences Europe, ISSN 2190-4707, E-ISSN 2190-4715, Vol. 30, article id 46Article, review/survey (Refereed)
    Abstract [en]

    The numbers of potential neurotoxicants in the environment are raising and pose a great risk for humans and the environment. Currently neurotoxicity assessment is mostly performed to predict and prevent harm to human populations. Despite all the efforts invested in the last years in developing novel in vitro or in silico test systems, in vivo tests with rodents are still the only accepted test for neurotoxicity risk assessment in Europe. Despite an increasing number of reports of species showing altered behaviour, neurotoxicity assessment for species in the environment is not required and therefore mostly not performed. Considering the increasing numbers of environmental contaminants with potential neurotoxic potential, eco-neurotoxicity should be also considered in risk assessment. In order to do so novel test systems are needed that can cope with species differences within ecosystems. In the field, online-biomonitoring systems using behavioural information could be used to detect neurotoxic effects and effect-directed analyses could be applied to identify the neurotoxicants causing the effect. Additionally, toxic pressure calculations in combination with mixture modelling could use environmental chemical monitoring data to predict adverse effects and prioritize pollutants for laboratory testing. Cheminformatics based on computational toxicological data from in vitro and in vivo studies could help to identify potential neurotoxicants. An array of in vitro assays covering different modes of action could be applied to screen compounds for neurotoxicity. The selection of in vitro assays could be guided by AOPs relevant for eco-neurotoxicity. In order to be able to perform risk assessment for eco-neurotoxicity, methods need to focus on the most sensitive species in an ecosystem. A test battery using species from different trophic levels might be the best approach. To implement eco-neurotoxicity assessment into European risk assessment, cheminformatics and in vitro screening tests could be used as first approach to identify eco-neurotoxic pollutants. In a second step, a small species test battery could be applied to assess the risks of ecosystems.

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