oru.sePublikasjoner
Endre søk
Begrens søket
1 - 44 of 44
RefereraExporteraLink til resultatlisten
Permanent link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Treff pr side
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sortering
  • Standard (Relevans)
  • Forfatter A-Ø
  • Forfatter Ø-A
  • Tittel A-Ø
  • Tittel Ø-A
  • Type publikasjon A-Ø
  • Type publikasjon Ø-A
  • Eldste først
  • Nyeste først
  • Skapad (Eldste først)
  • Skapad (Nyeste først)
  • Senast uppdaterad (Eldste først)
  • Senast uppdaterad (Nyeste først)
  • Disputationsdatum (tidligste først)
  • Disputationsdatum (siste først)
  • Standard (Relevans)
  • Forfatter A-Ø
  • Forfatter Ø-A
  • Tittel A-Ø
  • Tittel Ø-A
  • Type publikasjon A-Ø
  • Type publikasjon Ø-A
  • Eldste først
  • Nyeste først
  • Skapad (Eldste først)
  • Skapad (Nyeste først)
  • Senast uppdaterad (Eldste først)
  • Senast uppdaterad (Nyeste først)
  • Disputationsdatum (tidligste først)
  • Disputationsdatum (siste først)
Merk
Maxantalet träffar du kan exportera från sökgränssnittet är 250. Vid större uttag använd dig av utsökningar.
  • 1.
    Bereketoglu, Ceyhun
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik. Biology, The Life Science Center.
    Pradhan, Ajay
    Örebro universitet, Institutionen för naturvetenskap och teknik. Biology, The Life Science Center.
    Comparative transcriptional analysis of methylparaben and propylparaben in zebrafish2019Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 671, s. 129-139Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Parabens are widely used as preservatives in different commercial items including food, cosmetics and pharmaceuticals, and their wide use has resulted in accumulation in the environment. Parabens have been shown to have negative effects on animals as well as human health. In this study, we carried out a comprehensive study to determine the adverse effects associated with propylparaben (PP) and methylparaben (MP) on early developmental stages of zebrafish. Mortality, hatching, developmental abnormalities and gene expression profiles were investigated in embryos exposed to both compounds. The semi-static exposure conditions showed that both MP (>= 100 mu M) and PP (>= 10 mu M) are toxic to the embryos in a concentration-dependent manner and lead to developmental abnormality. Malformations such as spinal defects, pericardial edema, and pigmentation defects were observed following both MP and PP treatments. Hatching delay, mortality and developmental abnormality data indicate that PP is more toxic than MP. For gene expression analysis, 1 and 10 mu M doses of MP and PP were analyzed. Genes from physiological pathways including stress response, cell cycle and DNA damage, inflammation, fatty acid metabolism and endocrine functions were affected by MP and PP. The gene expression profiles show that parabens cause toxicity by inducing oxidative stress, DNA double-strand breaks, apoptosis as well as by altering fatty acid metabolism. Altered expression of androgen receptor (ar) and estrogen receptor 2 alpha (esr2a) indicates an antiandrogenic and estrogenic activity of parabens in zebrafish. Overall, the present study provides considerable information on the negative effects of MP and PP using physiological endpoints and motivates further studies to explore the molecular mechanism of the toxicity associated with parabens.

  • 2.
    Bjurlid, Filip
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Kärrman, Anna
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Ricklund, Niklas
    Department of Occupational and Environmental Medicine, Örebro University Hospital, Örebro, Sweden.
    Hagberg, Jessika
    Örebro universitet, Institutionen för naturvetenskap och teknik. Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Occurrence of brominated dioxins in a study using various firefighting methods2017Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 599-600, s. 1213-1221Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The use of different firefighting methods influences how fast a fire is extinguished and how fast the temperature drops in the area affected by the fire. These differences may also influence the formation of harmful pollutants during firefighting of an accidental fire. The aim was to study occurrence of brominated dibenzo-p-dioxins and furans (PBDD/Fs) in gas and soot during five fire scenarios resembling a small apartment fire and where different firefighting methods were used. Samples of gas and soot were taken both during the buildup of the fire and during the subsequent extinguishing of the fire while using different firefighting methods (nozzle, compressed air foam system, cutting extinguisher) and an extinguishing additive. New containers equipped with identical sets of combustible material were used for the five tests. The use of different firefighting methods and extinguishing additive induced variations in concentration and congener profiles of detected PBDD/Fs. The concentration range of Sigma PBDD/Fs in gas was 4020-18,700 pg/m(3), and in soot 76-4092 pg/m(2). PBDFs were the predominant congeners and 1,2,3,4,6,7,8-HpBDF was the most abundant congener. Chlorinated dibenzo-p-dioxins and furans (PCDD/Fs) were also monitored. The PBDD/Fs contributed with in average 97% to the total (PCDD/Fs plus PBDD/Fs) toxic equivalents, in soot and gas. During extinguishing, the shorter time the temperature was around 300 degrees C, the lower occurrence of PBDD/Fs. In the study the firefighting methods showed a difference in how effectively they induced a temperature decrease below 300 degrees C in the fire zone during quenching, where cutting extinguishing using additive and the compressed air foam system showed the fastest drop in temperature.

  • 3.
    Bjurlid, Filip
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Roos, Anna
    Department of Environmental Research and Monitoring, Swedish Museum of Natural History, Stockholm, Sweden.
    Ericson Jogsten, Ingrid
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Hagberg, Jessika
    Örebro universitet, Institutionen för naturvetenskap och teknik. Department of Occupational and Environmental Medicine, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
    Temporal trends of PBDD/Fs, PCDD/Fs, PBDEs and PCBs in ringed seals from the Baltic Sea (Pusa hispida botnica) between 1974 and 20152018Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 616-617, s. 1374-1383Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Temporal trends in exposure to persistent organic pollutants (POPs) were assessed in 22 pooled samples gathered from 69 individuals of Baltic ringed seal (Pusa hispida botnica) from 1974 to 2015. Samples were analysed for polybrominated dibenzo-p-dioxins and furans (PBDD/Fs), polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs), polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs). No previous study has reported on the occurrence of PBDD/Fs in marine mammals in the Baltic Sea. Concentrations of pollutants in Baltic ringed seal, a marine mammal and top predator, can be used as an indicator of pollutants concentrations in the Baltic region.

    Visual inspection of data did not show any temporal trends for PBDD/Fs, while the PCDD/Fs and PCBs showed decreasing concentrations between 1974 and 2015. PBDEs increased until the end of the 1990s and then decreased until the end of the period. ∑ PBDD/Fs ranged from 0.5–52.3 pg/g lipid weight (l.w.) (0.08–4.8 pg TEQ/g l.w.), with 1,2,3,4,6,7,8-HpBDF contributing on average 61% to ∑ PBDD/Fs. ∑ PCDD/Fs ranged from 103 to 1480 pg/g l.w. (39–784 pg TEQ/g l.w.), with 1,2,3,6,7,8-HxCDD, 1,2,3,7,8-PeCDD and 2,3,4,7,8-PeCDF showing the highest average concentrations. PBDD/F toxic equivalents (TEQ) contributed on average 1.1% to the total (PBDD/F + PCDD/F) TEQ. The ∑ PBDEs concentration range was 18.7–503 ng/g l.w., with BDE #47 the predominant congener. The concentration range for ∑ PCBs was 2.8–40.1 μg/g l.w., with #138 and #153 the most abundant congeners. Visual inspection of the data showed decreasing concentrations for all compound groups except PBDD/Fs. A slight increase in the PBDD/Fs concentrations was observed from 2004 onwards. This observation needs to be investigated further.

  • 4.
    Blanc, Mélanie
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Kärrman, Anna
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Kukučka, Petr
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Scherbak, Nikolai
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Keiter, Steffen
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Mixture-specific gene expression in zebrafish (Danio rerio) embryos exposed to perfluorooctane sulfonic acid (PFOS), perfluorohexanoic acid (PFHxA) and 3,3′,4,4′,5-pentachlorobiphenyl (PCB126)2017Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 590-591, s. 249-257Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Perfluorooctane sulfonic acid (PFOS) and 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) are persistent organic pollutants of high concern because of their environmental persistence, bioaccumulation and toxic properties. Besides, the amphiphilic properties of fluorinated compounds such as PFOS and perfluorohexanoic acid (PFHxA) suggest a role in increasing cell membrane permeability and solubilizing chemicals. The present study aimed at investigating whether PFOS and PFHxA are capable of modifying the activation of PCB126 toxicity-related pathways. For this purpose, zebrafish embryos were exposed in semi-static conditions to 7.5 μg/L of PCB126 alone, in the presence of 25 mg/L of PFOS, 15.7 mg/L of PFHxA or in the presence of both PFOS and PFHxA. Quantitative PCR was performed on embryos aged from 24 h post fertilization (hpf) to 96 hpf to investigate expression changes of genes involved in metabolism of xenobiotics (ahr2, cyp1a), oxidative stress (gpx1a, tp53), lipids metabolism (acaa2, osbpl1a), and epigenetic mechanisms (dnmt1, dnmt3ba). Cyp1a and ahr2 expression were significantly induced by the presence of PCB126. However, after 72 and 78 h of exposure, induction of cyp1a expression was significantly lower when embryos were co-exposed to PCB126 + PFOS + PFHxA when compared to PCB126-exposed embryos. Significant upregulation of gpx1a occurred after exposure to PCB126 + PFHxA and to PCB126 + PFOS + PFHxA at 30 and 48 hpf. Besides, embryos appeared more sensitive to PCB126 + PFOS + PFHxA at 78 hpf: acaa2 and osbpl1a were significantly downregulated; dnmt1 was significantly upregulated. While presented as environmentally safe, PFHxA demonstrated that it could affect gene expression patterns in zebrafish embryos when combined to PFOS and PCB126, suggesting that such mixture may increase PCB126 toxicity. This is of particular relevance since PFHxA is persistent and still being ejected into the environment. Moreover, it provides additional information as to the importance to integrate mixture effects of chemicals in risk assessment and biomonitoring frameworks.

  • 5.
    Bräunig, Jennifer
    et al.
    Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Coopers Plains QLD, Australia.
    Baduel, Christine
    Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Coopers Plains QLD, Australia.
    Heffernan, Amy
    Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Coopers Plains QLD, Australia; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville VIC, Australia.
    Rotander, Anna
    Örebro universitet, Institutionen för naturvetenskap och teknik. Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Coopers Plains QLD, Australia.
    Donaldson, Eric
    Aviation Medical Specialist, Oakey Qld, Australia.
    Mueller, Jochen F.
    Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, Coopers Plains QLD, Australia.
    Fate and redistribution of perfluoroalkyl acids through AFFF-impacted groundwater2017Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 596, s. 360-368Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Leaching of perfluoroalkyl acids (PFAAs) from a local point source, a fire-fighting training area, has led to extensive contamination of a groundwater aquifer which has spread underneath part of a nearby town, Oakey, situated in the State of Queensland, Australia. Groundwater is extracted by residents from privately owned wells for daily activities such as watering livestock and garden beds. The concentration of 10 PFAAs in environmental and biological samples (water, soil, grass, chicken egg yolk, serum of horses, cattle and sheep), as well as human serum was investigated to determine the extent of contamination in the town and discuss fate and redistribution of PFAAs. Perfluorooctane sulfonate (PFOS) was the dominant PFAA in all matrices investigated, followed by perfluorohexane sulfonate (PFHxS). PFOS concentrations measured in water ranged between <0.17-14 mu g/L, concentrations of PFHxS measured between <0.07-6 mu g/L. PFAAs were detected in backyards (soil, grass), livestock and chicken egg yolk. Significant differences (p < 0.01) in PFOS and PFHxS concentrations in two groups of cattle were found, one held within the contamination plume, the other in the vicinity but outside of the contamination plume. In human serum PFOS concentrations ranged from 38 to 381 mu g/L, while PFHxS ranged from 39 to 214 mu g/L. Highest PFOS concentrations measured in human serum were >30-fold higher compared to the general Australian population. Through use of contaminated groundwater secondary sources of PFAA contamination are created on private property, leading to further redistribution of contamination and creation of additional human exposure pathways.

  • 6.
    Bäckström, Mattias
    et al.
    Örebro universitet, Institutionen för naturvetenskap.
    Dario, Mårten
    Örebro universitet, Institutionen för naturvetenskap.
    Allard, Bert
    Örebro universitet, Institutionen för naturvetenskap.
    Karlsson, Stefan
    Örebro universitet, Institutionen för naturvetenskap.
    Effects of a fulvic acid on the adsorption of mercury and cadmium on goethite2003Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 304, nr 1-3, s. 257-268Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The effects of an aquatic fulvic acid on the pH-dependent adsorption of Hg(II) and Cd(II) to particulate goethite (a-FeOOH) were studied in batch systems. The ionic medium consisted of 0.01 M HClO and the total concentrations 4 of mercury and cadmium were maintained at 10y8 M with 203Hg and 109Cd as tracers. pH In the systems was varied in the range 3–10 by addition of HClO and NaOH.All commercial chemicals were of analytical grade or better. An 4 aquatic fulvic acid (20 ppm), previously isolated and characterised in detail, was used as a model for humic substances and its adsorption to goethite is included in this study. The adsorption of the fulvic acid (20 ppm) onto goethite decreased slowly from 90% at pH 3–7.5 to 10% at pH 10. In systems without fulvic acid the adsorption of mercury increased in a linear fashion from 10% at pH 3 to 70% at pH 10.In the presence of fulvic acid (20 ppm), the adsorption was almost quantitative in the intermediate pH range (pH 5–7), and exceeded 92% over the entire pH range. Thus, association between mercury and the fulvic acid enhanced adsorption in general although the largest impact was found at low pH.Adsorption of cadmium increased from nearly 0 to almost 100% at approximately pH 6. In the presence of fulvic acid, the adsorption increased below pH 7 and decreased above pH 7. The adsorption isotherm for mercury when the concentration was increased from 10y8 to 1.8=10y4 M showed a corresponding increase of K (lyg) up to a total concentration at 10y6 M.At higher mercury concentrations K was lowered. In the presence of fulvic acid the corresponding relationship of K was bi-modal, i.e. high values at low and intermediate concentrations of mercury. This behaviour suggests that in the absence of fulvic acid the adsorption follow the expected behaviour, i.e. adsorption sites with similar affinity for mercury. In the presence of fulvic acid, additional adsorption sites are available by the organic molecule (possibly sulfur groups) when it is associated to the goethite. The adsorption isotherm for cadmium indicates a lowering of K at 10y4 M. Cadmium had no competitive effect on mercury and vice versa. Zinc, however, affected the adsorption of cadmium but not the adsorption of mercury.

  • 7. Bäckström, Mattias
    et al.
    Dario, Mårten
    Örebro universitet, Institutionen för naturvetenskap.
    Karlsson, Stefan
    Allard, Bert
    Örebro universitet, Institutionen för naturvetenskap.
    Effects of a fulvic acid on the adsorption of mercury and cadmium on goethite2003Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 304, nr 1-3, s. 257-268Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The effects of an aquatic fulvic acid on the pH-dependent adsorption of Hg(II) and Cd(II) to particulate goethite (alpha-FeOOH) were studied in batch systems. The ionic medium consisted of 0.01 M HClO(4) and the total concentrations of mercury and cadmium were maintained at 10(-8) M with 203Hg and 109Cd as tracers. pH In the systems was varied in the range 3-10 by addition of HClO(4) and NaOH. All commercial chemicals were of analytical grade or better. An aquatic fulvic acid (20 ppm), previously isolated and characterised in detail, was used as a model for humic substances and its adsorption to goethite is included in this study. The adsorption of the fulvic acid (20 ppm) onto goethite decreased slowly from 90% at pH 3-7.5 to 10% at pH 10. In systems without fulvic acid the adsorption of mercury increased in a linear fashion from 10% at pH 3 to 70% at pH 10. In the presence of fulvic acid (20 ppm), the adsorption was almost quantitative in the intermediate pH range (pH 5-7), and exceeded 92% over the entire pH range. Thus, association between mercury and the fulvic acid enhanced adsorption in general although the largest impact was found at low pH. Adsorption of cadmium increased from nearly 0 to almost 100% at approximately pH 6. In the presence of fulvic acid, the adsorption increased below pH 7 and decreased above pH 7. The adsorption isotherm for mercury when the concentration was increased from 10(-8) to 1.8 x 10(-4) M showed a corresponding increase of K(d) (l/g) up to a total concentration at 10(-6) M. At higher mercury concentrations K(d) was lowered. In the presence of fulvic acid the corresponding relationship of K(d) was bi-modal, i.e. high values at low and intermediate concentrations of mercury. This behaviour suggests that in the absence of fulvic acid the adsorption follow the expected behaviour, i.e. adsorption sites with similar affinity for mercury. In the presence of fulvic acid, additional adsorption sites are available by the organic molecule (possibly sulfur groups) when it is associated to the goethite. The adsorption isotherm for cadmium indicates a lowering of K(d) at 10(-4) M. Cadmium had no competitive effect on mercury and vice versa. Zinc, however, affected the adsorption of cadmium but not the adsorption of mercury.

  • 8.
    Callan, Anna
    et al.
    School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia; Centre for Ecosystem Management, Edith Cowan University, Joondalup, Australia.
    Rotander, Anna
    National Research Centre for Environmental Toxicology (Entox), The University of Queensland, Coopers Plains, Australia.
    Thompson, Kristie
    National Research Centre for Environmental Toxicology (Entox), The University of Queensland, Coopers Plains, Australia.
    Heyworth, Jane
    School of Population Health, The University of Western Australia, Crawley, Australia.
    Mueller, Jochen F.
    National Research Centre for Environmental Toxicology (Entox), The University of Queensland, Coopers Plains, Australia.
    Odland, Jon Øyvind
    Department of Community Medicine, The Arctic University of Norway, Tromsø, Norway.
    Hinwood, Andrea
    Centre for Ecosystem Management, Edith Cowan University, Joondalup, Australia.
    Maternal exposure to perfluoroalkyl acids measured in whole blood and birth outcomes in offspring2016Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 569-570, s. 1107-1113Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Perfluoralkyl and polyfluoralkyl substances have been measured in plasma and serum of pregnant women as a measure of prenatal exposure. Increased concentrations of individual perfluoroalkyl acids (PFAAs), (typically perfluorooctanoic acid (PFOA) and perfluoroctane sulfonate (PFOS) have been reported to be associated with reductions in birth weight and other birth outcomes. We undertook a study of 14 PFAAs in whole blood (including PFOS, PFHxS, PFHpA, PFOA, PFNA, PFDA and PFUnDA) from 98 pregnant women in Western Australia from 2008 to 2011. Median concentrations (in μg/L) were: PFOS 1.99; PFHxS 0.33; PFOA 0.86; PFNA 0.30; PFDA 0.12 and PFUnDA 0.08. Infants born to women with the highest tertile of PFHxS exposure had an increased odds of being < 95% of their optimal birth weight (OR 3.5, 95% CI 1.1–11.5). Conversely, maternal blood concentrations of PFUnDA were associated with non-significant increases in average birth weight (+ 102 g, 95% CI − 41, 245) and significant increases in proportion of optimal birth weight (+ 4.7%, 95% CI 0.7, 8.8) per ln-unit change. This study has reported a range of PFAAs in the whole blood of pregnant women and suggests that PFHxS and PFUnDA may influence foetal growth and warrant further attention. Additional studies are required to identify the sources of PFAA exposure with a view to prevention, in addition to further studies investigating the long term health effects of these ubiquitous chemicals.

  • 9. Covaci, Adrian
    et al.
    Voorspoels, Stefan
    Thomsen, Cathrine
    van Bavel, Bert
    Örebro universitet, Institutionen för naturvetenskap.
    Neels, Hugo
    Evaluation of total lipids using enzymatic methods for the normalization of persistent organic pollutant levels in serum2006Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 366, nr 1, s. 361-366Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The human exposure to persistent organic pollutants (POPs) is conveniently assessed through analysis of blood serum or plasma and the POPs concentrations are traditionally expressed on a lipid weight basis. Enzymatic determinations of total lipid (TL) content in serum, which imply the measurement of individual lipid classes, such as triglycerides (TG), cholesterol (CHOL) and phospholipid (PL), use small amounts of serum/plasma (<100 microl). These have also become a more precise and less laborious alternative for the gravimetric lipid determinations which were preferred in the past. However, PL are not routinely measured in most clinical laboratories and therefore, TL values are often predicted from formulas based on measurements of only TG and CHOL. In the present study, a large data set (n=483) from Belgian, Swedish and Norwegian populations was used to compute a new formula for TL [TL=1.33*TG+1.12*CHOL+1.48 (g/l)] by means of multiple linear regression. A very good correlation (r=0.949, p<0.001) was found between TL values calculated with the proposed formula and TL values obtained by summation of TG, CHOL and PL. Statistically different values of TL were computed when different previously published formulas were compared, which can have a strong influence on the calculation of lipid-normalized concentrations of POPs. Nevertheless, TL values derived using a mathematical formula which includes only TG and CHOL will be less accurate than TL values obtained by summation of TG, CHOL and PL, which should be the calculation method of choice if PL measurements are available.

  • 10.
    Eichbaum, Kathrin
    et al.
    Dept Ecosystem Anal, Inst Environm Res, Rheinisch-Westfälische Technische Hochschule (RWTH), Aachen, Germany.
    Brinkmann, Markus
    Dept Ecosystem Anal, Inst Environm Res, Rheinisch-Westfälische Technische Hochschule (RWTH), Aachen, Germany.
    Buchinger, Sebastian
    Dept Biochem G3, Fed Inst Hydrol BFG, Koblenz, Germany.
    Reifferscheid, Georg
    Dept Biochem G3, Fed Inst Hydrol BFG, Koblenz, Germany.
    Hecker, Markus
    Sch Environm & Sustainabil, Univ Saskatchewan, Saskatoon, Canada; Toxicol Ctr, Univ Saskatchewan, Saskatoon, Canada.
    Giesy, John P.
    School of the Environment and Sustainability and Toxicology Centre, University of Saskatchewan, Saskatoon, Canada; Department of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan, Saskatoon, Canada; Department of Zoology and Center for Integrative Toxicology, Michigan State University, East Lansing MI, United States; Department of Biology and Chemistry, State Key Laboratory in Marine Pollution, City University of Hong Kong, Hong Kong, China; School of Biological Sciences, University of Hong Kong, Hong Kong, China.
    Engwall, Magnus
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    van Bavel, Bert
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Hollert, Henner
    Institute for Environmental Research, Department of Ecosystem Analysis, Rheinisch-Westfälische Technische Hochschule (RWTH), Aachen University, Aachen, Germany; Key Laboratory of Yangtze River Environment of Education Ministry of China, College of Environmental Science and Engineering, Tongji University, Shanghai, China; College of Resources and Environmental Science, Chongqing University, Chongqing, China; School of Environment, Nanjing University, Nanjing, China.
    In vitro bioassays for detecting dioxin-like activity: Application potentials and limits of detection, a review2014Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 487, s. 37-48Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Use of in vitro assays as screening tool to characterize contamination of a variety of environmental matrices has become an increasingly popular and powerful toolbox in the field of environmental toxicology.

    While bioassays cannot entirely substitute analytical methods such as gas chromatography-mass spectrometry (GC-MS), the increasing improvement of cell lines and standardization of bioassay procedures enhance their utility as bioanalytical pre-screening tests prior to more targeted chemical analytical investigations. Dioxin-receptor-based assays provide a holistic characterization of exposure to dioxin-like compounds (DLCs) by integrating their overall toxic potential, including potentials of unknown DLCs not detectable via e.g. GC-MS. Hence, they provide important additional information with respect to environmental risk assessment of DLCs.

    This review summarizes different in vitro bioassay applications for detection of DLCs and considers the comparability of bioassay and chemical analytically derived toxicity equivalents (TEQs) of different approaches and various matrices. These range from complex samples such as sediments through single reference to compound mixtures. A summary of bioassay derived detection limits (LODs) showed a number of current bioassays to be equally sensitive as chemical methodologies, but moreover revealed that most of the bioanalytical studies conducted to date did not report their LODs, which represents a limitation with regard to low potency samples.

    (C) 2014 Elsevier B.V. All rights reserved.

  • 11.
    Elmarghani, Ahmed
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Pradhan, Ajay
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Seyoum, Asmerom
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Khalaf, Hazem
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Ros, Torbjön
    Pelagia Miljokonsult AB, Umeå, Sweden.
    Forsberg, Lars-Håkan
    Mälarenergi AB, Vasterås, Sweden.
    Nermark, Tomas
    Karlskoga Energi MO AB, Karlskoga, Sweden.
    Osterman, Lisa
    Skebäcks Reningsverk, Örebro, Sweden.
    Wiklund, Ulf
    Tyrens AB, Umeå, Sweden.
    Ivarsson, Per
    ALS Scandinavia AB, Täby, Sweden.
    Jass, Jana
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Olsson, Per-Erik
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Contribution of pharmaceuticals, fecal bacteria and endotoxin to the inflammatory responses to inland waters2014Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 488-489, s. 228-235Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The increasing contamination of freshwater with pharmaceuticals, surfactants, pesticides and other organic compounds are of major concern. As these contaminants are detected at trace levels in the environment it is important to determine if they elicit biological responses at the observed levels. In addition to chemical pollutants, there is also a concern for increasing levels of bacteria and other microorganisms in freshwater systems. In an earlier study, we observed the activation of inflammatory systems downstream of a wastewater treatment plant (WWTP) in southern Sweden. We also observed that the water contained unidentified components that were pro-inflammatory and potentiated the immune response in human urinary bladder epithelial cells. In order to determine if these effects were unique for the studied site or represent a common response in Swedish water, we have now performed a study on three WWTPs and their recipient waters in central Sweden. Analysis of immune responses in urinary bladder epithelial cells, monocyte-like cells and blood mononuclear cells confirm that these waters activate the immune system as well as induce pro-inflammatory responses. The results indicate that the cytokine profiles correlate to the endotoxin load of the waters rather than to the levels of pharmaceuticals or culturable bacteria load, suggesting that measurements of endotoxin levels and immune responses would be a valuable addition to the analysis of inland waters.

  • 12.
    Engwall, Magnus
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Schnürer, A.
    Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden .
    Fate of Ah-receptor agonists in organic household waste during anaerobic degradation: estimation of levels using EROD induction in organ cultures of chick embryo livers2002Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 297, nr 1-3, s. 105-108Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The fate of 7-ethoxyresorufin O-deethylase (EROD)-inducing compounds in source-separated organic household waste subject to anaerobic degradation (i.e. mesophilic/thermophilic anaerobic treatment) was investigated using organ cultures of embryonic chicken livers from fertilised hen eggs. This bioassay reflects the combined effect of all EROD-inducing, possibly dioxin-like compounds in a sample, including chemicals that are seldom or never analysed. All samples tested induced EROD in the bioassay, indicating the presence of dioxin-like compounds. In the anaerobic processes, the amounts of acid-resistant EROD-inducing compounds coming out of the reactors were considerably higher than the incoming amounts, especially for the low-temperature (mesophilic) process. This apparent production of EROD-inducing compounds may be due to de novo synthesis or to an increase in the EROD-inducing potency of the compounds in the material.

  • 13.
    Gong, Wenwen
    et al.
    School of Environment, Beijing Key Laboratory for Emerging Organic Contaminants Control, State Key Joint Laboratory of Environment Simulation and Pollution Control (SKLESPC), Tsinghua University, Beijing, China.
    Fiedler, Heidelore
    Örebro universitet, Institutionen för naturvetenskap och teknik. School of Environment, Beijing Key Laboratory for Emerging Organic Contaminants Control, State Key Joint Laboratory of Environment Simulation and Pollution Control (SKLESPC), Tsinghua University, Beijing, China.
    Liu, Xiaotu
    School of Environment, Beijing Key Laboratory for Emerging Organic Contaminants Control, State Key Joint Laboratory of Environment Simulation and Pollution Control (SKLESPC), Tsinghua University, Beijing, China.
    Wang, Bin
    School of Environment, Beijing Key Laboratory for Emerging Organic Contaminants Control, State Key Joint Laboratory of Environment Simulation and Pollution Control (SKLESPC), Tsinghua University, Beijing, China.
    Yu, Gang
    School of Environment, Beijing Key Laboratory for Emerging Organic Contaminants Control, State Key Joint Laboratory of Environment Simulation and Pollution Control (SKLESPC), Tsinghua University, Beijing, China.
    Reassessment and update of emission factors for unintentional dioxin-like polychlorinated biphenyls2017Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 605, s. 498-506Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    One of the major goals of the Stockholm Convention on Persistent Organic Pollutants is to continuously reduce the releases of unintentional persistent organic pollutants (POPs) such as polychlorinated dibenzo-paradioxins and dibenzofurans (PCDD/PCDF) or polychlorinated biphenyls (PCB) from anthropogenic sources. Until now, most efforts have focused on the releases of PCDD/PCDF and to a lesser extent on unintentionally generated PCB, and therefore, release inventories reported as toxic equivalents (TEQ) do not include the twelve dioxin-like PCB (dl-PCB). In order to facilitate the development of national release inventories for the total TEQ - consisting of PCDD, PCDF and PCB - this study collected and summarized published emission factors (EFs) of unintentional dl-PCB or calculated them from measured data for the sources listed in the UNEP Toolkit. In total, 286 EFs for dl-PCB were found (or could be calculated) whereby 233 described release to air, 23 EFs addressed to residue, 25 EFs to product; and only 5 EFs addressed releases to land. Taking into account performance criteria such as the facility type and scale or abatement technologies, the EFs were grouped and assigned to the source categories and/or classes used in the UNEP Toolkit. With these newly added data and EFs of dl-PCB, the already existing EFs in the Toolkit can be improved and amended. In addition, a statistically significant correlation between the EFAir of dl-PCB proposed in this study and EFAir of PCDD/PCDF recommended in the Toolkit was observed.

  • 14.
    Grahn, Evastina
    et al.
    Örebro universitet, Institutionen för naturvetenskap.
    Karlsson, Stefan
    Örebro universitet, Institutionen för naturvetenskap.
    Düker, Anders
    Örebro universitet, Institutionen för naturvetenskap.
    Sediment reference concentrations of seldom monitored trace elements (Ag, Be, In, Ga, Sb, Tl) in four Swedish boreal lakes: comparison with commonly monitored elements2006Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 367, nr 2-3, s. 778-790Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This paper presents reference and recent acid-leachable concentrations of some seldom monitored trace elements (SMTE; Ag, Be, Ga, In, Sb and Tl) in sediments from four boreal oligotrophic lakes in a south to north transect in Sweden. For comparison commonly monitored trace elements (As, Cd, Co, Cr, Cu, Ni, Pb and Zn) are included as well as those of relevance for redistribution processes (Al, Ca, Fe, Mg and Mn).

    Pore water pH and the corresponding solid/solution distribution coefficients (Kd) indicated that redistribution of the elements due to acidification is minor. The depth of impact was defined as the level in the sediment where the mean values became constant on successive exclusion of metal concentrations in overlying strata. Reference concentrations were calculated below the depth of impact. The present concentration changes are estimated by the ratio between the average concentration above the depth of impact and the reference concentration.

    Reference concentration ranges for the SMT-elements are (mg/kg, dry wt.): Ag 0.16–0.66; Be 1.6–3.7; Ga 2.0–5.1; In 0.05–0.22; Sb 0.05–0.11 and Tl 0.17–0.70. The concentration ratios for these elements ranged in the two most southern lakes from 1.5 to 4.5 and in the two northern ones from 0.6 to 1.6. A high correlation between Kd for the SMT-elements, and iron, except for Sb and Tl, infer that the biogeochemistry of iron is quantitatively important for the accumulation of these elements.

    The reference concentration ranges for the commonly monitored trace elements are (mg/kg, dry wt.): As 7.0–29.6; Cd 0.33–0.98; Co 5.7–23.8; Cr 15.2–26.1; Cu 27.6–58.4; Ni 5.4–20.8; Pb 44–96. The corresponding concentration ratios were 1.2–18 (second highest 3.9) in the two most southern lakes and 0.8–1.6 in the two northern ones. Declining ratios were found from south to north, most obvious for cobalt and zinc. The copper ratios did not show a regional pattern, partly because of the impact from old mine waste.

    Increased concentrations of Ag, Be, Ga, In, Sb and Tl in recent sediments up to 4.5 times the reference levels in combination with the geographical pattern infer an elevated loading of these elements.

  • 15.
    Guan, Qingxia
    et al.
    School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, China.
    Tan, Hongli
    School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, China.
    Yang, Liu
    School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, China.
    Liu, Xiaotu
    School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, China.
    Fiedler, Heidelore
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Li, Xue
    Institute of Mass Spectrometer and Atmospheric Environment, Jinan University, Guangzhou, China.
    Chen, Da
    School of Environment, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, China.
    Isopropylated and tert-butylated triarylphosphate isomers in house dust from South China and Midwestern United States2019Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 686, s. 1113-1119Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In the present study we determined the concentrations and compositions of a suite of isopropylated and tert-butylated triarylphosphate ester (ITP and TBPP) isomers in house dust from the city of Guangzhou located in South China and the city of Carbondale in Midwestern United States. These two groups of organophosphate esters (OPE) are structurally analogous to triphenyl phosphate (TPHP), but have rarely been investigated for environmental occurrences and human exposure risks. The majority of target ITP and TBPP isomers were 100% detected in house dust from the two locations. Median concentrations of Sigma ITPs (including all ITP isomers) and Sigma TBPPs (including all TBPP isomers) were 63.4 ng/g (range: 16.0-500 ng/g) and 35.4 ng/g (8.1-198 ng/g) in South China house dust, respectively, compared with 476 ng/g (140-1610 ng/g) for Sigma ITPs and 81.3 ng/g (352-800 ng/g) for Sigma TBPPs in Midwestern US. dust. The profiles of ITP or TBPP isomers were similar between the two locations and were dominated by 2-isopropylphenyl diphenyl phosphate (2IPPDPP) and 4-tertbutylphenyl diphenyl phosphate (4tBPDPP), respectively. Although the levels of Sigma ITPs and Sigma TBPPs were generally one order of magnitude lower than those of TPHP in the same dust samples, the broad occurrences of most of these isomers in house dust from the two locations likely suggest their wide applications in household consumer products. Estimated intakes of Sigma ITPs and Sigma ITBPPs via dust ingestion were generally three orders of magnitude lower than the reference dose proposed for TPHP. However, these emerging OPE chemicals merit continuous environmental surveillance, given their possible applications as specific commercial mixtures or as components/impurities in other flame retardant/plasticizer mixtures. (C) 2019 Published by Elsevier B.V.

  • 16.
    Guo, J.
    et al.
    School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
    Wu, C.
    School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
    Qi, X.
    School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
    Jiang, S.
    School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China; Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
    Liu, Q.
    School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
    Zhang, J.
    School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
    Cao, Yang
    Örebro universitet, Institutionen för medicinska vetenskaper. Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Chang, X.
    School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
    Zhou, Z.
    School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
    Adverse associations between maternal and neonatal cadmium exposure and birth outcomes2017Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 575, s. 581-587Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Effects of low-level cadmium (Cd) exposure during early life on fetal growth remain unclear. Our aim was to evaluate whether Cd exposure in maternal urine and umbilical cord blood was associated with birth size parameters. A birth cohort study including 1073 mother-newborn pairs was conducted from 2009 to 2010 in an agricultural population in China. Cd concentrations were analyzed in both cord blood and maternal urine. Generalized linear models were performed to determine associations between maternal and neonatal exposure to Cd and birth indicators, including birth weight, length, head circumference and ponderal index. The median (25th to 75th percentile) value of Cd concentration in maternal urine and umbilical cord blood was 0.19 (0.08, 1.00) mug/L and 0.40 (<LOD~0.62) mug/L, respectively. After adjusting for potential confounders, Cd concentration in cord blood was significantly negatively associated with ponderal index at birth [beta=-0.06g/cm3, 95% confidence interval (CI): -0.11, -0.02; p<0.01]. Considering sex difference, significant reduction in ponderal index was only observed in males (beta=-0.06g/cm3, 95%CI: -0.11, -0.02; p<0.01), but not in females (beta=-0.03g/cm3, 95%CI: -0.07, 0.01; p=0.18) (p for interaction term=0.24). Additionally, no significant associations were observed between maternal urinary Cd levels and birth outcomes. Our findings suggest that adverse effects of neonatal exposure to Cd on fetal growth are of considerable public health importance.

  • 17.
    Gustavsson, L.
    et al.
    Örebro universitet, Institutionen för naturvetenskap.
    Engwall, Magnus
    Örebro universitet, Institutionen för naturvetenskap.
    Genotoxic activity of nitroarene-contaminated industrial sludge following large-scale treatment in aerated and non-aerated sacs2006Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 367, nr 2-3, s. 694-703Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    An industrial sludge containing a complex mixture of nitroaromatic compounds was treated in industrial large-scale aerobic and anaerobic biodegradation processes, performed in compost sacs. The goal was to study changes in genotoxicity during the two different oxygen regimes using the umuC genotoxicity assay. The composting sac was actively aerated during 3 months and allowed to mature for another 3 months. The anaerobic sac was not aerated for 5 months and aerated during the last month in order to enhance degradation of remaining organic carbon. The sludge was obtained from the wastewater treatment plant at an industrial area in Karlskoga, Sweden. The biodegradation study was performed at a commercial waste treatment plant in Stockholm, according to the company routine procedure when treating household waste in sealed sacs.

    The material from the non-aerated system showed increased genotoxicity in the acetone-soluble fraction after treatment, as did the water-soluble fraction. The subsequent aeration period did not decrease the toxicity below the genotoxicity limit. The increase in the water-soluble genotoxic compounds may pose an environmental problem during secondary storage or use of sludge treated this way, since leakage of water-dissolved genotoxic compounds may occur.

    The composting process also generated genotoxicity, but this was restricted to acetone-soluble compounds, while the water-soluble compounds remained low in genotoxicity. The aerated process therefore seems more favorable in term of risk reduction of this industrial sludge, although it is necessary to optimize the aerated process in order to achieve non-toxic levels of potential genotoxic compounds extractable by organic solvents.

  • 18.
    Hardell, Elin
    et al.
    Örebro University hospital, Örebro, Sweden.
    Carlberg, Michael
    Örebro University hospital, Örebro, Sweden.
    Nordstrom, Marie
    Dept Hematol, Karolinska Univ Hosp Solna, Stockholm, Sweden.
    van Bavel, Bert
    Örebro universitet, Akademin för naturvetenskap och teknik.
    Time trends of persistent organic pollutants in Sweden during 1993-2007 and relation to age, gender, body mass index, breast-feeding and parity2010Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 408, nr 20, s. 4412-4419Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Persistent organic pollutants (POPs) are lipophilic chemicals that bioaccumulate. Most of them were resticted or banned in the 1970s and 1980s to protect human health and the environment. The main source for humans is dietary intake of dairy products, meat and fish. Little data exist on changes of the concentration of POPs in the Swedish population over time. Objective: To study if the concentrations of polychlorinated biphenyls (PCBs). DDE, hexachlorobenzene (HCB) and chlordanes have changed in the Swedish population during 1993-2007, and certain factors that may influence the concentrations. Methods: During 1993-2007 samples from 537 controls in different human cancer studies were collected and analysed. Background information such as body mass index, breast-feeding and parity was assessed by questionaires. Wilcoxon rank-sum test was used to analyse the explanatory factors specimen (blood or adipose tissue), gender, BMI, total breast-feeding and parity in relation to POPs. Time trends for POPs were analysed using linear regression analysis, adjusted for specimen, gender, BMI and age. Results: The concentration decreased for all POPs during 1993-2007. The annual change was statistically significant for the sum of PCBs -7.2%, HCB -8.8%, DDE -13.5% and the sum of chlordanes -10.3%. BMI and age were determinants of the concentrations. Cumulative breast-feeding >8 months gave statistically significantly lower concentrations for the sum of PCBs. DDE and the sum of chlordanes. Parity with >2 children yielded statistically significantly lower sum of PCBs. Conclusions: All the studied POPs decreased during the time period, probably due to restrictions of their use. (c) 2010 Elsevier BM. All rights reserved.

  • 19.
    Henriksson, Sara
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik. Environmental Staff, Arvika, Sweden.
    Bjurlid, Filip
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Rotander, Anna
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Engwall, Magnus
    Lindström, Gunilla
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Westberg, Håkan
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Hagberg, Jessika
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Uptake and bioaccumulation of PCDD/Fs in earthworms after in situ and in vitro exposure to soil from a contaminated sawmill site2017Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 580, s. 564-571Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Uptake of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) was studied in earthworms collected from a sawmill site in Sweden with severe PCDD/Fs contamination (the hot spot concentration was 690,000 ng TEQWHO2005/kg d.w.) in order to investigate the transfer of PCDD/Fs from the site to the biota. PCDD/Fs concentrations in the collected earthworms were compared to PCDD/Fs concentrations in laboratory exposed earthworms (Eisenia fetida), which were exposed to contaminated soils from the sawmill site for 34 days. All analyses were performed by high resolution gas chromatography/high resolution mass spectrometry (HRGC/HRMS). PCDD/Fs concentrations in the earthworms ranged from 290 to 520,000 pg/g (f.w.). The main congeners found in both soils and earthworms were OCDF, 1234678-HpCDF, OCDD and 1234678-HpCDD. The study showed that the PCDD/Fs in the soil were biovailable to the earthworms and the PCDD/Fs concentrations in the soils correlated with the concentrations in the earthworms. Earthworm samples from soil with lower concentration had higher bioaccumulation factors than samples from soils with high concentration of contamination. Thus, a less contaminated soil could yield higher concentrations in earthworms compared to a higher contaminated soil. Assuming that when assessing risks with PCDD/F contaminated soil, a combination of chemical analysis of soil PCDD/Fs concentrations and bioavailability should be employed for a more comprehensive risk assessment.

  • 20.
    Hollert, Henner
    et al.
    Institute for Environmental Research (Biology V), Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany; College of Environmental Science and Engineering and State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanhai, China; School of Environment, Nanjing University, Nanjing, China; College of Resources and Environmental Science, Chongqing University, Chongqing, China.
    Crawford, Sarah E.
    Institute for Environmental Research (Biology V), Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany.
    Brack, Werner
    Institute for Environmental Research (Biology V), Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany; Department Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.
    Brinkmann, Markus
    Institute for Environmental Research (Biology V), Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany; Toxicology Centre, University of Saskatchewan, Saskatoon, Canada.
    Fischer, Elske
    Laboratory for Archaeobotany, Landesamt für Denkmalpflege im Regierungspräsidium Stuttgart, Gaienhofen-Hemmenhofen, Germany.
    Hartmann, Kai
    Institute for Geographical Sciences, Freie Universität Berlin, Berlin, Germany.
    Keiter, Steffen
    Örebro universitet, Institutionen för naturvetenskap och teknik. Institute for Environmental Research (Biology V), Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany.
    Ottermanns, Richard
    Institute for Environmental Research (Biology V), Department of Environmental Biology and Chemodynamics, RWTH Aachen University, Aachen, Germany.
    Ouellet, Jacob D.
    Institute for Environmental Research (Biology V), Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany.
    Rinke, Karsten
    Department of Lake Research, Helmholtz Centre for Environmental Research - UFZ, Magdeburg, Germany.
    Rösch, Manfred
    Laboratory for Archaeobotany, Landesamt für Denkmalpflege im Regierungspräsidium Stuttgart, Gaienhofen-Hemmenhofen, Germany.
    Ross-Nickoll, Martina
    Institute for Environmental Research (Biology V), Department of Environmental Biology and Chemodynamics, RWTH Aachen University, Aachen, Germany.
    Schäffer, Andreas
    Institute for Environmental Research (Biology V), Department of Environmental Biology and Chemodynamics, RWTH Aachen University, Aachen, Germany.
    Schüth, Christoph
    Institute for Applied Geoscience, Technische Universität Darmstadt, Darmstadt, Germany; Institute of Geosystems and Bioindication, Technische Universität Braunschweig, Braunschweig, Germany.
    Schulze, Tobias
    Department Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.
    Schwarz, Anja
    Institute of Geosystems and Bioindication, Technische Universität Braunschweig, Braunschweig, Germany.
    Seiler, Thomas-Benjamin
    Institute for Environmental Research (Biology V), Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany.
    Wessels, Martin
    Institute for Lake Research, State Institute for Environment, Measurements and Nature Conservation Baden-Württemberg (LUBW), Langenargen, Germany.
    Hinderer, Matthias
    Institute for Applied Geoscience, Technische Universität Darmstadt, Darmstadt, Germany.
    Schwalb, Antje
    Institute of Geosystems and Bioindication, Technische Universität Braunschweig, Braunschweig, Germany.
    Looking back - Looking forward: A novel multi-time slice weight-of-evidence approach for defining reference conditions to assess the impact of human activities on lake systems2018Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 626, s. 1036-1046Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Lake ecosystems are sensitive recorders of environmental changes that provide continuous archives at annual to decadal resolution over thousands of years. The systematic investigation of land use changes and emission of pollutants archived in Holocene lake sediments as well as the reconstruction of contamination, background conditions, and sensitivity of lake systems offer an ideal opportunity to study environmental dynamics and consequences of anthropogenic impact that increasingly pose risks to human well-being. This paper discusses the use of sediment and other lines of evidence in providing a record of historical and current contamination in lake ecosystems. We present a novel approach to investigate impacts from human activities using chemical-analytical, bioanalytical, ecological, paleolimnological, paleoecotoxicological, archeological as well as modeling techniques. This multi-time slice weight-of-evidence (WOE) approach will generate knowledge on conditions prior to anthropogenic influence and provide knowledge to (i) create a better understanding of the effects of anthropogenic disturbances on biodiversity, (ii) assess water quality by using quantitative data on historical pollution and persistence of pollutants archived over thousands of years in sediments, and (iii) define environmental threshold values using modeling methods. This technique may be applied in order to gain insights into reference conditions of surface and ground waters in catchments with a long history of land use and human impact, which is still a major need that is currently not yet addressed within the context of the European Water Framework Directive.

  • 21.
    Jayasinghe, Saroj
    et al.
    Faculty of Medicine, University of Colombo, Sri Lanka.
    Lind, Lars
    Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
    Salihovic, Samira
    Örebro universitet, Institutionen för naturvetenskap och teknik. Department of Medical Sciences and Science for Life Laboratory, Molecular Epidemiology Unit, Uppsala University, Uppsala, Sweden.
    Larsson, Anders
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
    Lind, P. Monica
    Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
    DDT and its metabolites could contribute to the aetiology of chronic kidney disease of unknown aetiology (CKDu) and more studies are a priority2019Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 649, s. 1638-1639Artikkel i tidsskrift (Annet vitenskapelig)
  • 22.
    Jayasinghe, Saroj
    et al.
    Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
    Lind, Lars
    Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
    Salihovic, Samira
    Örebro universitet, Institutionen för naturvetenskap och teknik. Department of Medical Sciences and Science for Life Laboratory, Molecular Epidemiology Unit, Uppsala University, Uppsala, Sweden.
    Larsson, Anders
    Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
    Lind, P. Monica
    Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
    High serum levels of p,p'-DDE are associated with an accelerated decline in GFR during 10 years follow-up2018Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 644, s. 371-374Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Over the past 20 years, the global incidence of chronic kidney disease (CKD) has been increasing and organochlorine pesticides (such as DDT) is a suspected etiological factor. The present study examines the associations between low level background exposure to p,p'-DDE (1-dichloro-2,2-bis (p-chlorophenyl) ethylene), the main DDT metabolite, and kidney function during a 10-year follow-up. Data was analysed from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (n = 1016, 50% women, all aged 70 years). Serum levels of p,p'-DDE was measured by gas chromatography coupled to high-resolution mass spectrometry (GC/HRMS) at baseline (i.e. age of 70 years). Glomerular filtration rate (GFR) was estimated using serum creatinine and cystatin C at 70, 75 and 80 years of age. A significant decline in GFR was seen during the 10-year follow-up (-24 ml/min/1.73 m2, p < 0.0001). A significant negative interaction was seen between baseline p,p'-DDE levels and change in GFR over time (p < 0.0001) following adjustment for sex, systolic blood pressure, diabetes, BMI, smoking and education level at age 70. Subjects with the lowest levels of p,p'-DDE levels at age 70 showed the lowest decline in GFR over 10 years, while subjects with the highest p,p'-DDE levels showed the greatest decline.

    Baseline levels of p,p'-DDE were related to an accelerated reduction in GFR over 10 years suggesting a nephrotoxic effect of DDT/p,p'-DDE. These findings support a potential role for DDT in the epidemic of CKD of unknown etiology (CKDu) in agricultural communities of Sri Lanka and Central America where DDT was previously used.

  • 23.
    Jin, Rong
    et al.
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
    Liu, Guorui
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
    Jiang, Xiaoxu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
    Liang, Yong
    Institute of Environment and Health, Jianghan University, Wuhan, China.
    Fiedler, Heidelore
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Yang, Lili
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
    Zhu, Qingqing
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
    Xu, Yang
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
    Gao, Lirong
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
    Su, Guijin
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
    Xiao, Ke
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
    Zheng, Minghui
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; Institute of Environment and Health, Jianghan University, Wuhan, China.
    Profiles, sources and potential exposures of parent, chlorinated and brominated polycyclic aromatic hydrocarbons in haze associated atmosphere2017Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 593-594, s. 390-398, artikkel-id S0048-9697(17)30654-XArtikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Profiles, sources and potential exposures of chlorinated and brominated polycyclic aromatic hydrocarbons (ClPAHs and BrPAHs) in haze associated atmosphere remain unclear. Haze events happened frequently during heating period in Beijing provided a typical urban context to investigate the concentrations, profiles, sources and potential exposures of ClPAHs, BrPAHs and their non-halogenated parent compounds (PAHs) in air samples. Average concentrations of PAHs, ClPAHs and BrPAHs during heating periods (with more frequent haze events) were about 3-9 times higher than during non-heating periods. Concentrations of particulate matter (PM)-associated ClPAHs and BrPAHs were higher in heating period than in non-heating period, while for gas-associated ClPAHs and BrPAHs, this distinction was not significant. Congener patterns and congener profiles indicated that with increasing coal combustion during the heating period, concentrations of PAHs and ClPAHs in air were elevated in comparison to the non-heating period. Inhalation of PM-associated PAHs, ClPAHs and BrPAHs accounted for higher exposure than inhalation of gas phase and dermal contact of both gas phase and particulate phase. In this study we found that the particulate phase is the dominant exposure pathway of atmospheric PAHs, ClPAHs and BrPAHs during haze days, which is different from previous studies.

  • 24.
    Johansson, Inger
    et al.
    Örebro universitet, Institutionen för naturvetenskap.
    van Bavel, Bert
    Örebro universitet, Institutionen för naturvetenskap.
    Levels and patterns of polycyclic aromatic hydrocarbons in incineration ashes2003Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 311, nr 1-3, s. 221-231Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Polycyclic aromatic hydrocarbons were analysed in weathered bottom ash from municipal solid waste incineration, fly ash from a mixed heating plant and an ash mixture from different kinds of biofuels. Although of different origin and age, all three ashes are evaluated in different small-scale fill applications. The ultimate goal is the usage of these ashes on a larger scale. The samples were Soxhlet extracted and analysed using GC/MS in the full scan mode. The sum of the 16 US EPA PAHs was found to vary from 140 mug/kg up to more than 77 000 mug/kg. Total amounts of PAHs were similar in bottom ash and in fly ash. The concentration in the mixed biofuel ash was more than 10 times higher, and exceeded the generic guidelines for PAHs in soil set by the Swedish Environmental Protection Agency. The patterns of the individual PAHs normalised to the total concentration of PAHs were found to be very similar for all the three ashes. Naphthalene and phenanthrene were the dominating PAHs for all ash samples, but the mixed biofuel ash also contained high levels of fluoranthene and pyrene. (C) 2003 Elsevier Science B.V. All rights reserved.

  • 25.
    Julander, Anneli
    et al.
    Örebro universitet, Akademin för naturvetenskap och teknik.
    Westberg, Håkan
    Engwall, Magnus
    Örebro universitet, Akademin för naturvetenskap och teknik.
    van Bavel, Bert
    Örebro universitet, Akademin för naturvetenskap och teknik.
    Distribution of brominated flame retardants in different dust fractions in air from an electronics recycling facility2005Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 350, nr 1-3, s. 151-160Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Twelve air samples were collected from an electronic recycling facility in Sweden representing three different dust fractions; respirable, total and inhalable dust. Four samples were collected from each fraction. The highest concentration of polybrominated diphenyl ether (PBDE) #209 (ten bromine atoms) was found in the samples from the inhalable dust fraction (ID), which was 10 times higher than for the "total dust" fraction (TD). The concentration ranges were 157.6-208.6; 13.9-16.7; and 2.8-3.3 ng/m3 for inhalable, total and respirable fractions, respectively. The second most abundant PBDE congener was PBDE #183 (seven bromine atoms), followed by the second most abundant substance 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) in all samples. In addition, decabromodiphenyl ethane (DeBDethane) was tentatively identified in five of the samples. Because of the large differences in air concentrations between the three fractions in ID, TD and RD, it is suggested that the inhalable instead of "total dust" fraction should be used to assess air concentrations, in particular for the larger and higher brominated flame retardants (BFRs).

  • 26.
    Kais, Britta
    et al.
    Aquatic Ecology and Toxicology Group, Center for Organismal Studies (COS), University of Heidelberg, Heidelberg, Germany.
    Schiwy, Sabrina
    Department of Ecosystem Analysis, Institute for Environmental Research, ABBt - Aachen Biology and Biotechnology, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University, Aachen, Germany.
    Hollert, Henner
    Department of Ecosystem Analysis, Institute for Environmental Research, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany.
    Keiter, Steffen
    Örebro universitet, Institutionen för naturvetenskap och teknik. Department of Ecosystem Analysis, Institute for Environmental Research, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Aachen, Germany.
    Braunbeck, Thomas
    Aquatic Ecology and Toxicology Group, Center for Organismal Studies (COS), University of Heidelberg, Heidelberg, Germany.
    In vivo EROD assays with the zebrafish (Danio rerio) as rapid screening tools for the detection of dioxin-like activity2017Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 590-591, s. 269-280Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The present study compares two alternative in vivo approaches for the measurement of ethoxyresorufin-Odeethylase (EROD) activity in zebrafish (Danio rerio) following exposure to acetonic model sediment extracts: (1) the live-imaging EROD assay for the direct detection of EROD induction in individual livers via epifluorescence, and (2) the fish embryo EROD assay in subcellular fractions derived from entire zebrafish embryos after in vivo exposure.

    For toxicity assessment, each sediment extract was tested with the standard fish embryo test (FET). Upon completion of a functioning liver after 72 h, the embryos gave a distinct fluorescent signal in the liver, and a corresponding EROD activity could be detected in the fish embryo EROD assay. The exposure time in the live-imaging EROD assay was reduced to 3 h, which resulted in a stronger, less variable and more sensitive EROD response. Overall, the live-imaging and the fish embryo EROD assays showed the same tendencies and gave comparable results, e.g. a concentration-dependent increase in EROD activity at concentrations one order of magnitude below concentrations producing macroscopically visible abnormalities. At higher concentrations, however, a decrease of EROD activity was observed in either test. Both tests ranked the three model sediment extracts in the same order. Results indicate that both test systems complement each other and together provide a rapid and reliable in vivo tool to investigate the presence of dioxin-like substances in environmental samples.

  • 27.
    Karlsson, Marie
    et al.
    Örebro universitet, Institutionen för naturvetenskap.
    Ericson, I.
    van Bavel, Bert
    Örebro universitet, Institutionen för naturvetenskap.
    Jensen, J.-K.
    Dam, M.
    Levels of brominated flame retardants in Northern Fulmar (Fulmarus glacialis) eggs from the Faroe Islands2006Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 367, nr 2-3, s. 840-846Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Eggs from Northern Fulmars (Fulmarus glacialis) were sampled in the Faroe Islands. The content of the brominated flame retardants tri- to decabromodiphenyl ethers (BDEs) and 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) were determined in nine samples in concentrations ranging from non-detectable to 7 ng g− 1(l.w.). The BDE levels were similar as in an earlier study of BDE levels in the fulmar eggs from the Faroe Islands but 10–1000 times lower compared to studies of eggs from seabirds and birds of prey from Europe. The two hexaBDEs #153 and #154 were the most abundant congeners, which represented around 50% of the total mean BDE concentration. The levels of BDE #209 were below the limit of detection (1.24 ng g− 1 l.w.) except for one sample, which showed a concentration of 7.18 ng g− 1 l.w. BTBPE was detected in eight samples and the mean level was 0.11 ng g− 1 l.w. This concentration was 150 times lower than the average total BDE concentration (including BDEs #28, #47, #100, #99, #154, #153, #183, #209). BTBPE has only been detected once before in biota. Also other bromo-containing compounds were detected in the fulmar eggs. One group identified was the polybrominated biphenyls (PBBs), but because of the absence of reference standards in the lab, these could not be quantified.

  • 28.
    Keiter, Susanne
    et al.
    Aquatic Ecology and Toxicology Group, Centre for Organismal Studies, University of Heidelberg, Heidelberg, Germany.
    Burkhard-Medicke, Kathleen
    Department Bioanalytical Ecotoxicology, UFZ-Helmholtz Centre for Environmental Research, Leipzig, Germany.
    Wellner, Peggy
    Department Bioanalytical Ecotoxicology, UFZ-Helmholtz Centre for Environmental Research, Leipzig, Germany.
    Kais, Britta
    Aquatic Ecology and Toxicology Group, Centre for Organismal Studies, University of Heidelberg, Heidelberg, Germany.
    Färber, Harald
    Institute for Hygiene and Public Health, University of Bonn, Bonn, Germany.
    Skutlarek, Dirk
    Institute for Hygiene and Public Health, University of Bonn, Bonn, Germany.
    Engwall, Magnus
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Braunbeck, Thomas
    Aquatic Ecology and Toxicology Group, Centre for Organismal Studies, University of Heidelberg, Heidelberg, Germany.
    Keiter, Steffen
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Luckenback, Till
    Department Bioanalytical Ecotoxicology, UFZ-Helmholtz Centre for Environmental Research, Leipzig, Germany.
    Does perfluorooctane sulfonate (PFOS) act as chemosensitizer in zebrafish embryos?2016Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 548-549, s. 317-324Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Earlier studies have shown that perfluorooctane sulfonate (PFOS) increases the toxicity of other chemicals by enhancing their uptake by cells and tissues. The present study aimed at testing whether the underlying mechanism of enhanced uptake of chemicals by zebrafish (Danio rerio) embryos in the presence of PFOS is by interference of this compound with the cellular efflux transporter Abcb4. Modifications of uptake/clearance and toxicity of two Abcb4 substrates, the fluorescent dye rhodamine B (RhB) and vinblastine, by PFOS were evaluated using 24 and 48. h post-fertilization (hpf) embryos. Upon 90. min exposure of 24. hpf embryos to 1. μM RhB and different PFOS concentrations (3-300. μM) accumulation of RhB in zebrafish was increased by up to 11.9-fold compared to controls, whereas RhB increases in verapamil treatments were 1.7-fold. Co-administration of PFOS and vinblastine in exposures from 0 to 48. hpf resulted in higher vinblastine-caused mortalities in zebrafish embryos indicating increased uptake of this compound. Interference of PFOS with zebrafish Abcb4 activity was further studied using recombinant protein obtained with the baculovirus expression system. PFOS lead to a concentration-dependent decrease of the verapamil-stimulated Abcb4 ATPase activity; at higher PFOS concentrations (250, 500. μM), also the basal ATPase activity was lowered indicating PFOS to be an Abcb4 inhibitor. In exposures of 48. hpf embryos to a very high RhB concentration (200. μM), accumulation of RhB in embryo tissue and adsorption to the chorion were increased in the presence of 50 or 100. μM PFOS. In conclusion, the results indicate that PFOS acts as inhibitor of zebrafish Abcb4; however, the exceptionally large PFOS-caused effect amplitude of RhB accumulation in the 1. μM RhB experiments and the clear PFOS effects in the experiments with 200. μM RhB suggest that an additional mechanism appears to be responsible for the potential of PFOS to enhance uptake of Abcb4 substrates.

  • 29.
    Khalaf, Hazem
    et al.
    Örebro universitet, Hälsoakademin.
    Salste, Lotta
    Karlsson, Patrik
    Ivarsson, Per
    Jass, Jana
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Olsson, Per-Erik
    Örebro universitet, Akademin för naturvetenskap och teknik.
    In vitro analysis of inflammatory responses following environmental exposure to pharmaceuticals and inland waters2009Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 407, nr 4, s. 1452-1460Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Pharmaceuticals are regularly released into the environment; in particular non-steroidalanti-inflammatory drugs (NSAIDs) and antibiotics. Erythromycin, naproxen, furosemideand atenolol are reported to be stable for up to 1 year in the environment, which increasesthe risk for accumulation. In the present study we have measured the occurrence andconcentration of pharmaceuticals in river Viskan (Jössabron) downstream of a sewagetreatment plant in Borås, Sweden. Pharmaceuticals and water samples were tested forpotential human risk by evaluating inflammatory responses (NF-κB and AP-1) using humanT24 bladder epithelial cells and Jurkat T-cells. NF-κB activity in T24 cells was significantlyreduced by all NSAIDs analysed (diclofenac, ketoprofen, naproxen, ibuprophen anddextropropoxyphene), but also by trimethoprim, using environmentally relevantconcentrations. NF-κB and AP-1 activation was further analysed in response to watersamples collected from different locations in Sweden. Dose-dependent down-regulation ofAP-1 activity in Jurkat cells was observed at all locations. At two locations (Jössabron andAlmenäs) down-regulation of NF-κB was observed. In contrast, the NF-κB response waspotentiated by exposure to water from both locations following activation of NF-κB bytreatment with heat-killed Escherichia coli. To determine the involvement ofpharmaceuticals in the responses, T24 cells were exposed to the pharmaceutical mixture,based on the determined levels at Jössabron. This resulted in reduction of the NF-κBresponse following exposure to the pharmaceutical mixture alone while no potentiationwas observed when cells were co-exposed to heat killed E. coli and pharmaceuticals. Theobtained results demonstrate that the identified pharmaceuticals affect the inflammatoryresponses and furthermore indicate the presence of unknown substance(s) with the abilityto potentiate inflammatory responses

  • 30.
    Larsson, Maria
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Lam, Monika M.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    van Hees, Patrick
    Örebro universitet, Institutionen för naturvetenskap och teknik. Eurofins Environment Testing Sweden AB, Lidköping, Sweden.
    Giesy, John P.
    University of Saskatchewan, Saskatoon, Canada.
    Engwall, Magnus
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Occurrence and leachability of polycyclic aromatic compounds in contaminated soils: Chemical and bioanalytical characterization2018Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 622-623, s. 1476-1484Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    An important concern regarding sites contaminated with polycyclic aromatic compounds (PACs) is the risk of groundwater contamination by release of the compounds from soils. The goal of this study was to investigate the occurrence and leachability of 77 PACs including polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic compounds (NSO-PACs) among total aryl hydrocarbon receptor (AhR) agonists in soils from historical contaminated sites. A novel approach combining chemical and bioanalytical methods in combination with characterization of leachability by use of a column leaching test was used. Similar profiles of relative concentrations of PACs were observed in all soils, with parent PAHs accounting for 71 to 90% of total concentrations in soils. Contribution of oxy-PAHs, alkyl-PAHs and N-PACs ranged from 2 to 9%, 3 to 9% and 1 to 14%, respectively. Although the contributions of groups of PACs were small, some compounds were found in similar or greater concentrations than parent PAHs. Leachable fractions of 77 PACs from soils were small and ranged from 0.002 to 0.54%. Polar PACs were shown to be more leachable than parent PAHs. The contribution of analyzed PACS to overall AhR-mediated activities in soils and leachates suggests presence of other AhR agonists in soils, and a potential risk. Only a small fraction of AhR agonists was available in soils, indicating an overestimation of the risk if only total initial concentrations in soils would be considered in risk assessment. The results of the study strongly support that focus on 16US EPA PAHs may result in inadequate assessment of risk and hazard of PACs in complex environmental samples.

  • 31.
    Pan, Jing
    et al.
    National Research Center for Geoanalysis, Beijing, China.
    Yang, Yongliang
    National Research Center for Geoanalysis, Beijing, China.
    Zhu, Xiaohua
    National Research Center for Geoanalysis, Beijing, China.
    Yeung, Leo Wai Yin
    Department of Chemistry, University of Toronto, Toronto, Canada.
    Taniyasu, Sachi
    National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
    Miyake, Yuichi
    National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
    Falandysz, Jerzy
    Institute of Environmental Sciences and Public Health, University of Gdańsk, Gdańsk, Poland.
    Yamashita, Nobuyoshi
    National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
    Altitudinal distributions of PCDD/Fs, dioxin-like PCBs and PCNs in soil and yak samples from Wolong high mountain area, eastern Tibet-Qinghai Plateau, China2013Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 444, s. 102-109Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Topsoil along the altitudinal gradient (2086-4487m above sea level) and yak samples, collected from Wolong high mountain area of Sichuan Province, western China, were analyzed for polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs), dioxin-like polychlorinated biphenyls (dl-PCBs) and polychlorinated naphthalenes (PCNs) using HRGC-HRMS. The total concentrations of PCDD/Fs, dl-PCBs, and PCNs in soils were: 2.48-4.30pgg-1 dw (dry weight), 7.6-10.5pgg-1 dw, and 13.0-29.0pgg-1 dw, respectively; the greatest concentrations were found at sampling sites of 3927m, 4487m and 3345m, correspondingly. The total PCDD/Fs and dl-PCBs concentrations showed positive correlations with increasing altitudinal gradient. The congener profiles of both 2,3,7,8-PCDD/Fs and dl-PCBs at different altitudes showed similar patterns. PCNs were dominated by Tri-CNs. The long-range atmospheric transport and subsequent aerial deposition are likely the sources for these POPs in area examined. The total TEQs in soils were in the range of 0.28-0.42pgg-1 dw, and the total TEQs in the yak muscle and fatty tissue samples were 3.81-4.09pgTEQg-1 lipid weight. The daily intake of TEQs was estimated to be below the WHO's tolerable daily intake according to the local people's dietary habits in Wolong area, which is unlikely to cause any adverse health effects to the yak muscle consuming people.

  • 32.
    Paul, Sudip Kumar
    et al.
    Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh; Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.
    Islam, Md. Shofikul
    Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.
    Hasibuzzaman, M. M.
    Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
    Hossain, Faruk
    Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
    Anjum, Adiba
    Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
    Saud, Zahangir Alam
    Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
    Haque, Md. Mominul
    Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
    Sultana, Papia
    Department of Statistics, University of Rajshahi, Rajshahi, Bangladesh.
    Haque, Azizul
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston SC, USA.
    Andric, Klara Biljana
    Department of Biomedicine, University of Skövde, Skövde, Sweden.
    Rahman, Aminur
    Örebro universitet, Institutionen för naturvetenskap och teknik. The Life Science Center.
    Karim, Md Rezaul
    Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.
    Siddique, Abu Eabrahim
    Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
    Karim, Yeasir
    Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
    Rahman, Mizanur
    Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
    Miyataka, Hideki
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
    Xin, Lian
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
    Himeno, Seiichiro
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
    Hossain, Khaled
    Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
    Higher risk of hyperglycemia with greater susceptibility in females in chronic arsenic-exposed individuals in Bangladesh2019Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 668, s. 1004-1012Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Arsenic (As) toxicity and diabetes mellitus (DM) are emerging public health concerns worldwide. Although exposure to high levels of As has been associated with DM. whether there is also an association between low and moderate As exposure and DM remains unclear. We explored the dose-dependent association between As exposure levels and hyperglycemia, with special consideration of the impact of demographic variables, in 641 subjects from rural Bangladesh. The total study participants were divided into three groups depending on their levels of exposure to As in drinking water (low, moderate and high exposure groups). Prevalence of hyperglycemia, including impaired glucose tolerance (IGT) and DM was significantly associated with the subjects' drinking water arsenic levels. Almost all exposure metrics (As levels in the subjects' drinking water, hair and nails) showed dose-dependent associations with the risk or hyperglycemia, IGT and DM. Among the variables considered, sex, age, and BMI were found to be associated with higher risk of hyperglycemia. IGT and DM. In sex-stratified analyses, As exposure showed a clearer pattern of dose-dependent risk for hyperglycemia in females than males. Finally, drinking water containing low-to-moderate levels of As (50.01-150 mu g/L) was found to confer a greater risk of hyperglycemia than safe drinking water (As <= 10 mu g/L). Thus the results suggested that As exposure was dose-dependently associated with hyperglycemia, especially in females.

  • 33.
    Persson, Josefin
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Wang, Thanh
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Hagberg, Jessika
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Organophosphate flame retardants and plasticizers in indoor dust, air and window wipes in newly built low-energy preschools2018Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 628-629, s. 159-168Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The construction of extremely airtight and energy efficient low-energy buildings is achieved by using functional building materials, such as age-resistant plastics, insulation, adhesives, and sealants. Additives such as organophosphate flame retardants (OPFRs) can be added to some of these building materials as flame retardants and plasticizers. Some OPFRs are considered persistent, bioaccumulative and toxic. Therefore, in this pilot study, the occurrence and distribution of nine OPFRs were determined for dust, air, and window wipe samples collected in newly built low-energy preschools with and without environmental certifications. Tris(1,3-dichloroisopropyl) phosphate (TDCIPP) and triphenyl phosphate (TPHP) were detected in all indoor dust samples at concentrations ranging from 0.014 to 10 μg/g and 0.0069 to 79 μg/g, respectively. Only six OPFRs (predominantly chlorinated OPFRs) were detected in the indoor air. All nine OPFRs were found on the window surfaces and the highest concentrations, which occurred in the reference preschool, were measured for 2-ethylhexyl diphenyl phosphate (EHDPP) (maximum concentration: 1500 ng/m2). Interestingly, the OPFR levels in the environmental certified low-energy preschools were lower than those in the reference preschool and the non-certified low-energy preschool, probably attributed to the usage of environmental friendly and low-emitting building materials, interior decorations, and consumer products.

  • 34.
    Pradhan, Ajay
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Ivarsson, Per
    Örebro universitet, Institutionen för naturvetenskap och teknik. BioImpakt AB, Örebro, Sweden.
    Ragnvaldsson, Daniel
    Envix Nord AB, Umeå, Sweden.
    Berg, Håkan
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Jass, Jana
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Olsson, Per-Erik
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Transcriptional responses of zebrafish to complex metal mixtures in laboratory studies overestimates the responses observed with environmental water2017Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 584-585, s. 1138-1146Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Metals released into the environment continue to be of concern for human health. However, risk assessment of metal exposure is often based on total metal levels and usually does not take bioavailability data, metal speciation or matrix effects into consideration. The continued development of biological endpoint analyses are therefore of high importance for improved eco-toxicological risk analyses. While there is an on-going debate concerning synergistic or additive effects of low-level mixed exposures there is little environmental data confirming the observations obtained from laboratory experiments. In the present study we utilized qRT-PCR analysis to identify key metal response genes to develop a method for biomonitoring and risk-assessment of metal pollution. The gene expression patterns were determined for juvenile zebrafish exposed to waters from sites down-stream of a closed mining operation. Genes representing different physiological processes including stress response, inflammation, apoptosis, drug metabolism, ion channels and receptors, and genotoxicity were analyzed. The gene expression patterns of zebrafish exposed to laboratory prepared metal mixes were compared to the patterns obtained with fish exposed to the environmental samples with the same metal composition and concentrations. Exposure to environmental samples resulted in fewer alterations in gene expression compared to laboratory mixes. A biotic ligand model (BLM) was used to approximate the bioavailability of the metals in the environmental setting. However, the BLM results were not in agreement with the experimental data, suggesting that the BLM may be overestimating the risk in the environment. The present study therefore supports the inclusion of site-specific biological analyses to complement the present chemical based assays used for environmental risk-assessment.

  • 35.
    Rai, Neha
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik. The Life Science Centre - Biology.
    Sjöberg, Viktor
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Forsberg, Göran
    Detectum AB, Jönköping, Sweden.
    Karlsson, Stefan
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Olsson, Per-Erik
    Örebro universitet, Institutionen för naturvetenskap och teknik. The Life Science Centre - Biology.
    Jass, Jana
    Örebro universitet, Institutionen för naturvetenskap och teknik. The Life Science Centre - Biology.
    Metal contaminated soil leachates from an art glass factory elicit stress response, alter fatty acid metabolism and reduce lifespan in Caenorhabditis elegans2019Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 651, s. 2218-2227Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The present study evaluated the toxicity of metal contamination in soils from an art glass factory in Smaland Sweden using a Caenorhabditis elegans nematode model. The aim of the study was to chemically analyze the soil samples and study the biological effects of water-soluble leachates on the nematodes using different physiological endpoints. The total metal content showed that As, Cd and Pb were at levels above the guideline values for soils in areas around the factory. Less than 10% of the total metal content in the soil was found in the water-soluble leachates, however, Al, As, Fe and Pb remained higher than the guideline values for safe drinking water. Exposure of C. elegans to the water-soluble leachates, at both post-hatching larvae stage (L1-young adult) for 48 h and at the young adult stage (L4) for 6 h, showed significant gene alteration. Although the nematodes did not exhibit acute lethality, lifespan was significantly reduced upon exposure. C. elegans also showed altered gene expression associated with stress response and fat metabolism, as well as enhanced accumulation of body fat. The study highlighted the significance of assessing environmental samples using a combination of gene expression analysis, fatty acid metabolism and lifespan for providing valuable insight into the negative impact of metals. The altered fat metabolism and reduced lifespan on exposure to soil leachates motivates further studies to explore the mechanism of the toxicity associated with the metals present in the environment.

  • 36.
    Rotander, Anna
    et al.
    Örebro universitet, Akademin för naturvetenskap och teknik.
    van Bavel, Bert
    Örebro universitet, Akademin för naturvetenskap och teknik.
    Rigét, Frank
    University of Aarhus, Roskilde, Denmark.
    Atli Audunsson, Gudjón
    Innovation Center Iceland, Reykjavik, Iceland.
    Polder, Anuschka
    Norwegian school of veterinary science, Oslo, Norway.
    Wing Gabrielsen, Geir
    Norwegian Polar Institute, FRAM Centre, Tromsø, Norway.
    Vikingsson, Gisli
    Marine Research Institute, Reykjavík, Iceland.
    Mikkelsen, Bjarni
    Museum of Natural History, Torshavn, Faroe Islands.
    Dam, Maria
    Environment Agency, Argir, Faroe Islands.
    Methoxylated polybrominated diphenyl ethers (MeO-PBDEs) are major contributors to the persistent organobromine load in sub-Arctic and Arctic marine mammals, 1986-20092012Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 416, s. 482-489Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A selection of MeO-BDE and BDE congeners were analyzed in pooled blubber samples of pilot whale (Globicephala melas), ringed seal (Phoca hispida), minke whale (Balaenoptera acutorostrata), fin whale (Balaenoptera physalus), harbor porpoise (Phocoena phocoena), hooded seal (Cystophora cristata), and Atlantic white-sided dolphin (Lagenorhynchus acutus), coveting a time period of more than 20 years (1986-2009). The analytes were extracted and cleaned-up using open column extraction and multi-layer silica gel column chromatography. The analysis was performed using both low resolution and high resolution GC-MS. MeO-PBDE concentrations relative to total PBDE concentrations varied greatly between sampling periods and species. The highest MeO-PBDE levels were found in the toothed whale species pilot whale and white-sided dolphin, often exceeding the concentration of the most abundant PBDE, BDE-47. The lowest MeO-PBDE levels were found in fin whales and ringed seals. The main MeO-BDE congeners were 6-MeO-BDE47 and 2'-MeO-BDE68. A weak correlation only between BDE47 and its methoxylated analog 6-MeO-BDE47 was found and is indicative of a natural source for MeO-PBDEs.

  • 37.
    Seyoum, Asmerom
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Pradhan, Ajay
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Effect of phthalates on development, reproduction, fat metabolism and lifespan in Daphnia magna2019Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 654, s. 969-977Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Phthalates are used as plasticizers to increase durability, resistivity and flexibility of plastic materials. The commonly used phthalate, diethylhexyl phthalate (DEHP) is used in different plastic materials like food packaging, toys and medical devices. DEHP has been linked to different toxicities in humans as well as in animals, and as a consequence other phthalates, including dibutyl phthalate (DBP) and diethyl phthalate (DEP) are being introduced. The increased use of phthalates has resulted in contamination of aquatic ecosystem and it directly threatens the aquatic life. In this study, we analyzed the effects of three phthalates DEHP, DEP and DBP using freshwater organism Daphnia magna. Although, exposure of the three phthalates at 1 and 10 μM did not result any lethality and hatching delay, the chronic exposure for 14 days resulted in reduction of body length. There was enhanced fat accumulation on exposure to all the phthalates, as indicated by oil red O staining. qRT-PCR analysis of genes involved in fat metabolism suggests that the increase in fat content could be due to inhibition of absorption and catabolism of fatty acids. Reproduction analysis showed that DBP and DEP did not alter fecundity but surprisingly, DEHP at 1 μM increased reproduction by 1.5 fold compared to control group. Phthalates also showed negative effect on lifespan as DEP at 10 μM and DBP at both 1 and 10 μM significantly reduced the lifespan. Our data indicates that along with the banned phthalate DEHP, the other substitute phthalates DEP and DBP could also have detrimental effect on aquatic organisms.

  • 38.
    Svensson, Margareta
    et al.
    Örebro universitet, Institutionen för naturvetenskap.
    Allard, Bert
    Örebro universitet, Institutionen för naturvetenskap.
    Düker, Anders
    Örebro universitet, Institutionen för naturvetenskap.
    Formation of HgS: mixing HgO or elemental Hg with S, FeS or FeS22006Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 368, nr 1, s. 418-423Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of this study is to assess the feasibility for generation of the sparingly soluble solid HgS from HgO or elemental Hg by mixing with a suitable sulphur source under various conditions (dry, wet at different pH, and room temperature). The formation of mercury sulphide was confirmed in 14 of the 36 combinations of Hg and S sources. Mercury sulphide was generally formed under alkaline conditions. Almost 100% HgS was obtained in anaerobic systems at high pH in the presence of elemental sulphur after about two years. Thus, it is feasible to create an environment at room temperature that, with time, leads to the generation of HgS from elemental Hg or HgO. This is relevant for the design of a repository for permanent geologic disposal of mercury. Choosing wrong components and conditions can however lead to a reduction of Hg(II) to elemental mercury.

  • 39.
    Söderqvist, Fredrik
    et al.
    Örebro universitet, Hälsoakademin.
    Carlberg, Michael
    Universitetssjukhuset Örebro.
    Hardell, Lennart
    Örebro universitet, Hälsoakademin.
    Use of wireless telephones and serum S100B levels: a descriptive cross-sectional study among healthy Swedish adults aged 18-65 years2009Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 407, nr 2, s. 798-805Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Since the late 1970s, experimental animal studies have been carried out on the possible effects of low-intensive radiofrequency fields on the blood-brain barrier (BBB), but no epidemiological study has been published to date. OBJECTIVE: Using serum S100B as a putative marker of BBB dysfunction we performed a descriptive cross-sectional study to investigate whether protein levels were higher among frequent than non-frequent users of mobile and cordless desktop phones. METHOD: One thousand subjects, 500 of each sex aged 18-65 years, were randomly recruited using the population registry. Data on wireless phone use were assessed by a postal questionnaire and blood samples were analyzed for S100B. RESULTS: The response rate was 31.4%. The results from logistic and linear regression analyses were statistically insignificant, with one exception: the linear regression analysis of latency for UMTS use, which after stratifying on gender remained significant only for men (p = 0.01; n = 31). A low p-value (0.052) was obtained for use of cordless phone (n = 98) prior to giving the blood samples indicating a weak negative association. Total use of mobile and cordless phones over time yielded odds ratio (OR) 0.8 and 95% confidence interval (CI) 0.3-2.0 and use on the same day as giving blood yielded OR=1.1, CI=0.4-2.8. CONCLUSIONS: This study failed to show that long- or short-term use of wireless telephones was associated with elevated levels of serum S100B as a marker of BBB integrity. The finding regarding latency of UMTS use may be interesting but it is based on small numbers. Generally, S100B levels were low and to determine whether this association - if causal - is clinically relevant, larger studies with sufficient follow-up are needed.

  • 40. Wolkers, Hans
    et al.
    van Bavel, Bert
    Örebro universitet, Akademin för naturvetenskap och teknik.
    Ericson (Jogsten), Ingrid
    Örebro universitet, Akademin för naturvetenskap och teknik.
    Skoglund, Eli
    Kovacs, Kit M.
    Lydersen, Christian
    Congener-specific accumulation and patterns of chlorinated and brominated contaminants in adult male walruses from Svalbard, Norway: indications for individual-specific prey selection2006Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 370, nr 1, s. 70-79Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Blubber samples from 17 adult, male walruses were sampled in eastern Svalbard and analyzed for chlorinated and brominated contaminants. A wide range of contaminants were detected, including PCBs (mean 2000; 95% range 1165-4005 ng/g lipid), DDE (mean 100: 95% range 50-310) ng/g lipid), chlordanes (mean 2500; 95% range 1347-5009) ng/g lipid, toxaphenes (mean 80; 95% range 51-132 ng/g lipid) and polybrominated diphenyl ethers (PBDEs) (mean 15 ng/g; 95% range 9-27 ng/g lipid). PCB and DDE levels were substantially lower than those of animals sampled 10 year earlier in this area, confirming a decreasing trend for these compounds in the Arctic. However, compared to other recently sampled marine mammals from Svalbard, walruses showed relatively high PCB and chlordane levels although they had lower levels of DDE, toxaphenes, and PBDEs, possibly due to species- and location-specific differences in exposure and metabolism. The range in contaminant levels found within the sample group was vast, despite the fact that the animals investigated were all adult males from the same location. The PCB pattern in highly contaminated animals was different from that in animals with low levels of contamination, with relatively more persistent PCBs in the highly contaminated group. This suggests that the more contaminated animals were feeding at higher trophic levels; possibly targeting seals in addition to mollusks as their prey. This suggestion was reinforced by the fatty acid profiles of the inner blubber layer of walruses with low versus high contaminant levels, which suggested different diets for the two groups.

  • 41.
    Yu, Junchao
    et al.
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; Environment Research Institute, Shandong University, Jinan, China.
    Wang, Thanh
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Han, Shanlong
    Environment Research Institute, Shandong University, Jinan, China.
    Wang, Pu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Zhang, Qinghua
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Jiang, Guibin
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Distribution of polychlorinated biphenyls in an urban riparian zone affected by wastewater treatment plant effluent and the transfer to terrestrial compartment by invertebrates2013Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 463-464, s. 252-257Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this study, we investigated the distribution of polychlorinated biphenyls (PCBs) in a riparian zone affected by the effluent from a wastewater treatment plant (WWTP). River water, sediment, aquatic invertebrates and samples from the surrounding terrestrial compartment such as soil, reed plants and several land based invertebrates were collected. A relatively narrow range of δ(13)C values was found among most invertebrates (except butterflies, grasshoppers), indicating a similar energy source. The highest concentration of total PCBs was observed in zooplankton (151.1 ng/g lipid weight), and soil dwelling invertebrates showed higher concentrations than phytophagous insects at the riparian zone. The endobenthic oligochaete Tubifex tubifex (54.28 ng/g lw) might be a useful bioindicator of WWTP derived PCBs contamination. High bioaccumulation factors (BAFs) were observed in collected aquatic invertebrates, although the biota-sediment/soil accumulation factors (BSAF) remained relatively low. Emerging aquatic insects such as chironomids could carry waterborne PCBs to the terrestrial compartment via their lifecycles. The estimated annual flux of PCBs for chironomids ranged from 0.66 to 265 ng⋅m(-2)⋅y(-1). Although a high prevalence of PCB-11 and PCB-28 was found for most aquatic based samples in this riparian zone, the mid-chlorinated congeners (e.g. PCB-153 and PCB-138) became predominant among chironomids and dragonflies as well as soil dwelling invertebrates, which might suggest a selective biodriven transfer of different PCB congeners.

  • 42.
    Zhang, Haiyan
    et al.
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Xiao, Ke
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Liu, Jiyan
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Wang, Thanh
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Liu, Guorui
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Wang, Yawei
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Jiang, Guibin
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Polychlorinated naphthalenes in sewage sludge from wastewater treatment plants in China2014Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 490, s. 555-560Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Polychlorinated naphthalenes (PCNs) were nominated as persistent organic pollutants candidate in the Stockholm Convention in 2011. In this study, the profiles, concentrations and spatial distributions of PCNs were analyzed in 30 sewage sludge samples from wastewater treatment plants (WWTPs) in China. Concentrations of Σ75PCNs in sludge samples were in the range of 1.05-10.9 ng/g dry weight (dw) with a mean value of 3.98 ng/g dw. The predominant homologues in the sludge were mono- to tetra-CNs, accounting for approximately 85% of total PCNs. The total toxic equivalent quantities (TEQs) of dioxin-like PCN congeners ranged from 0.04 to 2.28 pg/g dw with a mean value of 0.36 pg/g dw, which were lower than the maximum permissible TEQ concentrations in sludge for land application in China. Levels of PCNs and TEQs in sludge were relatively higher in samples from highly industrialized and developed cities in eastern China, implying a possible link between PCN contamination and the local economic development, but more studies are warranted to corroborate this. Industrial sources might be important contributors of PCNs to sewage sludge in China.

  • 43.
    Zhang, Jiming
    et al.
    School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
    Guo, Jianqiu
    School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
    Lu, Dasheng
    Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
    Qi, Xiaojuan
    School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
    Chang, Xiuli
    School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
    Wu, Chunhua
    School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
    Zhang, Yubin
    School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
    Liang, Weijiu
    Shanghai Center for Disease Control and Prevention, Shanghai, China.
    Fang, Xin
    Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
    Cao, Yang
    Örebro universitet, Institutionen för medicinska vetenskaper. Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
    Zhou, Zhijun
    School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China.
    Maternal urinary carbofuranphenol levels before delivery and birth outcomes in Sheyang Birth Cohort2018Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 625, s. 1667-1672Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Exposure to carbamates has been linked with adverse health effects on developmental period. This study aimed to monitor exposure to carbofuranphenol of pregnant women from Sheyang Birth Cohort and investigate associations between prenatal exposure to carbofuranphenol and birth outcomes. During June 2009 to January 2010, 1100 pregnant women living in Sheyang County participated in our study and donated urine sample. Urinary carbofuranphenol concentration was measured by gas chromatography-tandem mass spectrometry. Associations between urinary carbofuranphenol levels and infant birth outcomes were assessed by generalized linear models. Urinary carbofuranphenol concentrations varied from 0.01 to 395.40μg/L (0.01-303.93μg/g for creatinine adjusted), the geometric mean, median and inter quartile range are 0.81μg/L (1.28μg/g cr), 0.80μg/L (1.23μg/g cr) and 0.27-2.20μg/L (0.47-3.11μg/g cr), respectively. No statistically significant association between maternal urinary carbofuranphenol levels and birth outcomes was found in total infants and female infants. In male neonates, carbofuranphenol level was significantly associated with head circumference (b=-0.226; 95% confidence interval: -0.411, -0.041; P=0.01) and ponderal index (b=0.043, 95% CI: 0.004, 0.083; P=0.03). These findings suggested that the pregnant women were generally exposed to carbofuranphenol and prenatal exposure to carbofuranphenol might have adverse effects on fetal development.

  • 44.
    Zhu, Nali
    et al.
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Schramm, Karl-Werner
    Molecular EXposomics (MEX), Helmholtz Zentrum München Center for Environmental Health, Germany; Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt, Department für Biowissenschaften, Technical University of Munich (TUM), Freising, Germany.
    Wang, Thanh
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Henkelmann, Bernhard
    Molecular EXposomics (MEX), Helmholtz Zentrum München Center for Environmental Health, Germany.
    Fu, Jianjie
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Gao, Yan
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Wang, Yawei
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; Molecular EXposomics (MEX), Helmholtz Zentrum München Center for Environmental Health, Germany.
    Jiang, Guibin
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Lichen, moss and soil in resolving the occurrence of semi-volatile organic compounds on the southeastern Tibetan Plateau, China2015Inngår i: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 518, s. 328-336Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This study investigated a wide range of semi-volatile organic compounds (SVOCs), including 28 persistent organochlorine pesticides (OCPs), 18 polychlorinated biphenyls (PCBs), 13 polybrominated diphenyl ethers (PBDEs), and 3 hexabromocyclododecane (HBCD) congeners in lichen, moss and soil collected from the southeastern Tibetan Plateau, China. This allows research provides insight into elevation gradient distributions and possible cold trapping effects of SVOCs in this high mountain area, and compares lichens and mosses as air passive samplers for indicating SVOC occurrences. DDTs, endosulfans, HCHs and hexachlorobenzene predominated in all of the samples. Source analysis indicted that there were fresh inputs of DDTs and HCHs in the sampling region. Lichens and mosses shared commonalities in revealing the profiles and levels of SVOCs based on their lipid-content-normalized concentrations. The concentrations of 12 OCPs and 14 PCBs in lichens were significantly linearly correlated with altitudes, whereas the correlations for mosses and soil with altitudes were insignificant. Both a frequency distribution diagram and the Mountain Contamination Potential Model indicated that SVOCs with specific values of log K-OA (8-11) and log K-WA (2-4) had relative high mountain contamination potential on the Tibetan Plateau.

1 - 44 of 44
RefereraExporteraLink til resultatlisten
Permanent link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf