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  • 1.
    Erdtman, Edvin
    et al.
    Örebro universitet, Institutionen för naturvetenskap.
    dos Santos, Daniel J. V. A.
    Löfgren, Lennart
    Eriksson, Leif A.
    Örebro universitet, Institutionen för naturvetenskap.
    Modelling the behavior of 5-aminolevulinic acid and its alkyl esters in a lipid bilayer2008Inngår i: Chemical Physics Letters, ISSN 0009-2614, E-ISSN 1873-4448, Vol. 463, nr 1-3, s. 178-182Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    5-Aminolevulinic acid (5ALA) and ester derivates thereof are used as prodrugs in photodynamic therapy (PDT). The behavior of 5ALA and three esters of 5ALA in a DPPC lipid bilayer is investigated. In particular, the methyl ester displays a very different free energy profile, where the highest barrier is located in the region with highest lipid density, while the others have their peak in the middle of the membrane, and also displays a considerably lower permeability coefficient than neutral 5ALA and the ethyl ester. The zwitterion of 5ALA has the highest permeability constant, but a significant free energy minimum in the polar head-group region renders an accumulation in this region.

  • 2.
    Erdtman, Edvin
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    dos Santos, Daniel J. V. A.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Löfgren, Lennart
    Orebro Univ Hosp, Head & Neck Oncol Ctr, S-70185 Orebro, Sweden.
    Eriksson, Leif A.
    Örebro universitet, Institutionen för naturvetenskap.
    Modelling the behavior of 5-aminolevulinic acid and its alkyl esters in a lipid bilayer (vol 463, pg 178, 2008)2009Inngår i: Chemical Physics Letters, ISSN 0009-2614, E-ISSN 1873-4448, Vol. 470, nr 4-6, s. 369-369Artikkel i tidsskrift (Fagfellevurdert)
  • 3.
    Landström, Fredrik J
    et al.
    Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden.
    Nilsson, Christer O. S.
    Department of Otolaryngology, Örebro University Hospital, Örebro, Sweden.
    Crafoord, Sven
    Örebro universitet, Institutionen för läkarutbildning. Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden.
    Reizenstein, Johan A.
    Department of Oncology, Örebro University Hospital, Örebro, Sweden.
    Adamsson, Gun-Britt M.
    Department of Head and Neck Oncology Center, Örebro University Hospital, Örebro, Sweden.
    Löfgren, Lennart A.
    Department of Head and Neck Oncology Center, Örebro University Hospital, Örebro, Sweden.
    Electroporation therapy of skin cancer in the head and neck area.2010Inngår i: Dermatologic Surgery, ISSN 1076-0512, E-ISSN 1524-4725, Vol. 36, nr 8, s. 1245-50Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Electroporation therapy is a new cancer treatment modality in which a locally applied electrical field enhances cell membrane permeability, allowing greater intracellular accumulation of a chemotherapeutic agent.

    OBJECTIVE: To evaluate the efficacy of electroporation therapy in treating basal cell and squamous cell carcinomas of the skin.

    MATERIALS AND METHODS: Six patients with skin cancer of the head and neck were treated using electroporation therapy with intratumorally injected bleomycin. Orbital growth, facial nerve proximity, or proximity to cartilage of the external meatus complicated four of these tumors. The intention was curative. The follow-up period was 24 months and included biopsies after 8 weeks.

    RESULTS: In four of the six patients, one treatment was enough to eradicate the tumor. In one patient, the tumor persisted even after a second treatment with electroporation therapy. A septal cartilage perforation was the only major complication. The cosmetic results were very satisfactory. One additional recurrence was recorded 6 months after the follow-up period

    CONCLUSION: Electroporation therapy is a promising new cancer treatment that should be further evaluated as an alternative to surgery, especially in complicated skin cancer.

  • 4.
    Landström, Fredrik J.
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Örebro University Hospital, Örebro, Sweden.
    Nilsson, Christer O. S.
    Örebro University Hospital, Örebro, Sweden.
    Reizenstein, Johan A.
    Örebro University Hospital, Örebro, Sweden.
    Nordqvist, Kent
    Örebro University Hospital, Örebro, Sweden.
    Adamsson, Gun-Britt
    Örebro University Hospital, Örebro, Sweden.
    Löfgren, Lennart A.
    Dept Head & Neck, Center for Oncology, Örebro Univ Hospital, Örebro, Sweden.
    Electroporation therapy for T1 and T2 oral tongue cancer2011Inngår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 131, nr 6, s. 660-664Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Conclusion: Electroporation therapy appears to be a safe treatment achieving excellent local tumor control and very good functional results in our study and it should be further clinically evaluated.

    Objectives: The objectives of this study were to assess local tumor control, survival, and effects on speech and eating after treatment of tongue cancer with electroporation therapy, a new local therapeutic modality. In this approach intracellular accumulation of a chemotherapeutic agent is achieved by using a locally applied electrical field.

    Methods: Fifteen patients with primary T1 and T2 oral tongue cancer were treated with electroporation therapy with intratumorally administered bleomycin. Postoperative radiotherapy was performed when the tumor infiltration was 5 mm or more. The follow-up time was 24 months for the surviving patients and 20.4 months overall. The effects on eating and speech were assessed using the PSS-HN scale and voice recordings.

    Results: No local recurrence was recorded in any patient during the follow-up. Three patients died, two from progressive regional disease. Of the 12 surviving patients, 2 patients had regional recurrence and 10 patients including the 5 patients treated with EPT alone were tumor-free both locally and regionally at the last follow-up. The functional outcome for speech and eating were very good.

  • 5.
    Landström, Fredrik
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Örebro University Hospital, Örebro, Sweden.
    Reizenstein, Johan
    Örebro University Hospital, Örebro, Sweden.
    Nilsson, Christer
    Örebro University Hospital, Örebro, Sweden.
    von Beckerath, Mathias
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Löfgren, Lennart
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Adamsson, Gun-Britt
    Örebro University Hospital, Örebro, Sweden.
    Möller, Claes
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Electrochemotherapy - possible benefits and limitations to its use in the head and neck region2015Inngår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 135, nr 1, s. 90-95Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Conclusion: Electrochemotherapy (ECT) is an efficacious treatment. It should, however, be used with some caution in the treatment of head and neck cancer.

    Objectives: To assess local tumor control, safety, survival, and functional outcome after treatment of cancer in the head and neck region with ECT.

    Methods: Four patients with primary T2 cancer of the oral cavity or oropharynx and one patient with a metastasis of renal cancer in the masseter muscle were treated with ECT with intratumorally administered bleomycin. Control biopsies were carried out 2 months after treatment. Postoperative radiotherapy was performed based on tumor T-stage and the depth of tumor infiltration. Serious adverse events and treatment malfunctions were recorded. The follow-up time was 24 months for the surviving patients and 20 months overall. The PSS-HN scale was used to assess the functional outcome.

    Results: No local recurrence was recorded in any patient during the follow-up. However, only one patient was treated with ECT alone. There were four serious adverse events: one nearly lethal bleeding, two cases of osteoradionecrosis, and a fistula. One patient died from distant metastasis. The other patients were tumor-free both locally and overall at 24 months. The median functional outcome in all parameters was worse 1 year after treatment.

  • 6.
    von Beckerath, Mathias P.
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Region Örebro län. Dept Otolaryngol & Head & Neck Surg, Örebro University Hospital, Örebro, Sweden.
    Reizenstein, Johan A.
    Dept Oncol, Örebro Univ Hosp, Örebro, Sweden.
    Berner, Attila L.
    Dept Otolaryngol & Head & Neck Surg, Örebro Univ Hosp, Örebro, Sweden.
    Nordqvist, Kent W. O.
    Dept Logoped & Phoniatr, Örebro Univ Hosp, Örebro, Sweden.
    Landström, Fredrik J.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Dept Otolaryngol & Head & Neck Surg, Örebro Univ Hosp, Örebro, Sweden.
    Löfgren, Axel Lennart
    Örebro universitet, Institutionen för klinisk medicin. Dept Otolaryngol & Head & Neck Surg, Örebro Univ Hosp, Örebro, Sweden.
    Möller, Claes
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Region Örebro län. Audiology Reseach Center, Örebro University Hospital, Örebro, Sweden.
    Outcome of primary treatment of early laryngeal malignancies using photodynamic therapy2014Inngår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 134, nr 8, s. 852-858Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Conclusion: Photodynamic therapy (PDT) is a viable and safe option for early laryngeal cancer that would be less suitably treated with radiation or trans-oral laser surgery (TLS). The cure rates with PDT appear to be comparable to those of conventional therapy, and the voice outcomes are also comparable. In the case of many sarcomas, PDT appears to be an organ- and function-sparing therapy, although it is more costly than other treatments.

    Objectives: The aim of this study was to show the results of PDT when it is used as a primary treatment of early laryngeal cancer. Methods: We studied the results of PDT when used as a primary treatment. We looked at survival, effect on tumor, side effects, voice, and costs.

    Results: The follow-up period was a median of 59 months. Nine of 10 patients were cured of their laryngeal cancer. PDT alone cured seven patients. All four of the sarcomas were cured using temoporfin. Two of three tumors that involved the anterior commissure were cured using only interstitial illumination with PDT. No serious side effects were noted. The patient's voices were improved after treatment in 5 of 10 cases, and none had a worsened voice.

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