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  • 251.
    Logadottir, Yr
    et al.
    Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Delbro, Dick
    Örebro universitet, Institutionen för läkarutbildning.
    Fall, Magnus
    Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Gjertsson, Inger
    Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Jirholt, Pernilla
    Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Lindholm, Catharina
    Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Peeker, Ralph
    Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Cytokine Expression in Patients with Bladder Pain Syndrome/Interstitial Cystitis ESSIC Type 3C2014Ingår i: Journal of Urology, ISSN 0022-5347, E-ISSN 1527-3792, Vol. 192, nr 5, s. 1564-1568Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: Bladder wall nitric oxide production in patients with bladder pain syndrome type 3C is increased compared to undetectable nitric oxide in patients with nonHunner bladder pain syndrome and healthy controls. However, the underlying mechanism/s of the increased nitric oxide production is largely unknown. We compared mRNA expression of a select group of cytokines in patients with bladder pain syndrome/interstitial cystitis type 3C and in pain-free controls.

    Materials and Methods: Cold cup biopsies from 7 patients with bladder pain syndrome type 3C and 6 healthy subjects were analyzed. mRNA expression of IL-4, 6, 10 and 17A, iNOS, TNF-alpha, TGF-beta and IFN-gamma was estimated by real-time polymerase chain reaction. IL-17 protein expression was determined by immunohistochemistry. Mast cells were labeled with tryptase to evaluate cell appearance and count.

    Results: IL-6, 10 and 17A, and iNOS mRNA levels as well as the number of mast cells infiltrating the bladder mucosa were significantly increased in patients with bladder pain syndrome type 3C compared to healthy controls. TNF-alpha, TGF-beta and IFN-gamma mRNA levels were similar in patients and controls. IL-17A expression at the protein level was up-regulated and localized to inflammatory cells and urothelium in patients with bladder pain syndrome type 3C.

    Conclusions: Patients with bladder pain syndrome/interstitial cystitis had increased mRNA levels of IL-17A, 10 and 6, and iNOS. IL-17A might be important in the inflammatory process. To our knowledge the increase in IL-17A is a novel finding that may have new treatment implications.

  • 252.
    Logadottir, Yr
    et al.
    Department of Urology, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Delbro, Dick
    Örebro universitet, Institutionen för läkarutbildning.
    Lindholm, Catharina
    Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
    Fall, Magnus
    Sahlgrenska University Hospital, Gothenburg, Sweden.
    Peeker, Ralph
    Department of Urology, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Inflammation characteristics in bladder pain syndrome ESSIC type 3C/classic interstitial cystitis2014Ingår i: International journal of urology, ISSN 0919-8172, E-ISSN 1442-2042, Vol. 21, nr Suppl. 1, s. 75-78Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objectives: Interstitial cystitis is regarded as a heterogenous syndrome with two distinguishable forms: the non-ulcer and the classic form of interstitial cystitis, the latter with Hunner's lesions; or bladder pain syndrome type 3C and non-Hunner bladder pain syndrome, respectively.

    Methods: A cohort of 379 patients diagnosed with interstitial cystitis was studied. Nitric oxide release from the bladder was measured using a chemiluminescence nitric oxide analyzer. Bladder biopsies from the patients and healthy controls were analyzed by routine histopathological examination. Biopsies from a subset of patients and controls were also analyzed by immunohistochemistry and cytokine gene expression by real-time polymerase chain reaction.

    Results: Patients with bladder pain syndrome type 3C/classic interstitial cystitis had considerably higher levels of nitric oxide as compared with non-Hunner bladder pain syndrome/non-ulcer interstitial cystitis patients and healthy individuals, and showed histologically a chronic inflammation in the bladder mucosa, with abundant mast cell infiltration in all layers of the bladder wall. No inflammation was noted in non-Hunner bladder pain syndrome/non-ulcer interstitial cystitis patients. The isoenzymes inducible nitric oxide synthase, the catalyst in the nitric oxide production, was strongly expressed in the inflammatory cells in the bladder mucosa of bladder pain syndrome type 3C/classic interstitial cystitis patients. In addition, the expression of the pro-inflammatory cytokines interleukin-6 and interleukin-17A messenger ribonucleic acid, and of anti-inflammatory interleukin-10 messenger ribonucleic acid showed significantly increased levels in bladder pain syndrome type 3C/classic interstitial cystitis compared with healthy controls.

    Conclusion: Bladder pain syndrome type 3C/classic interstitial cystitis is a distinct inflammatory disease and in many aspects shares features of inflammatory autoimmune diseases. These findings could open up novel research avenues with expectations for new targets for pharmacological treatment.

  • 253.
    Lorenz, Linda
    Örebro universitet, Institutionen för läkarutbildning.
    Mineralocorticoid Receptor Antagonists – Treatment Following Renal Transplantation: An observational study investigating the effect of MR-antagonists on renal function in patients treated with calcineurin inhibitors2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 254.
    Lundqvist, Sonja
    Örebro universitet, Institutionen för läkarutbildning.
    Molecular mechanisms of a plant based diet on reduction of atherosclerosis: A systematic review of the literature2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 255.
    Lönn, Johanna
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. PEAS Institute, Linköping, Sweden; Clinical Research Center, Örebro University, Örebro, Sweden.
    Johansson, Carin Starkhammar
    Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; Centre for Oral Rehabilitation, Public Dental Health Care, County Council of Östergötland, Linköping, Sweden.
    Nakka, Sravya
    The Institution for Protein Environment Affinity Surveys (PEAS Institute), Linköping, Sweden.
    Palm, Eleonor
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Bengtsson, Torbjörn
    Örebro universitet, Institutionen för läkarutbildning.
    Nayeri, Fariba
    The Institution for Protein Environment Affinity Surveys (PEAS Institute), Linköping, Sweden ; Div Infect Dis, Linköping Univ Hosp, Linköping, Sweden.
    Ravald, Nils
    Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; Centre for Oral Rehabilitation, Public Dental Health Care, County Council of Östergötland, Linköping, Sweden.
    High Concentration but Low Activity of Hepatocyte Growth Factor in Periodontitis2014Ingår i: Journal of Periodontology, ISSN 0022-3492, E-ISSN 1943-3670, Vol. 85, nr 1, s. 113-122Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: High levels of hepatocyte growth factor (HGF), a healing factor with regenerative and cytoprotective effects, are associated with inflammatory diseases, including periodontitis. HGF biological activity requires binding to its receptors, the proto-oncogene c-Met (c-Met) and heparan sulphate proteoglycan (HSPG). Here we investigated HGF expression and its relationship to subgingival microbiota in medically healthy individuals with and without periodontitis.

    Methods: Saliva, gingival crevicular fluid (GCF), and blood samples from 30 patients with severe periodontitis and 30 healthy controls were analyzed for HGF concentration using enzyme-linked immunosorbent assay (ELISA), and binding affinity for HSPG and c-Met using surface plasmon resonance (SPR). The regenerative effects of saliva from three patients and controls were analyzed in an in vitro model of cell injury. Subgingival plaques were analyzed for the presence of 18 bacterial species.

    Results: Patients with periodontitis showed higher HGF concentrations in saliva, GCF, and serum (P < 0.001); however, the binding affinities for HSPG and c-Met were reduced in GCF and saliva (P < 0.002). In contrast to the controls, saliva from patients showed no significant regenerative effect over time on gingival epithelial cells. Compared to controls, patients had a higher prevalence of periodontal-related bacteria.

    Conclusion: Higher circulatory HGF levels indicate a systemic effect of periodontitis. However, the HGF biological activity at local inflammation sites was reduced, and this effect was associated with the amount of periodontal bacteria. Loss of function of healing factors may be an important mechanism in degenerative processes in periodontally susceptible individuals.

  • 256.
    Lönn, Johanna
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. PEAS Institute, Linköping, Sweden.
    Shahzad, Faisal
    PEAS Institute, Linköping, Sweden.
    Uhlin, Fredrik
    Department of Nephrology UHL, County Council of Östergötland, Linköping, Sweden; Department of Medicine and Health Science, Faculty of Health Science, Linköping University, Linköping, Sweden.
    Bengtsson, Torbjörn
    Örebro universitet, Institutionen för läkarutbildning. Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Almroth, Gabriel
    Department of Nephrology UHL, County Council of Östergötland, Department of Medicine and Health Science, Faculty of Health Science, Linköping University, Linköping, Sweden.
    Nayeri, Fariba
    PEAS Institute, Linköping, Sweden; Department of Molecular and Clinical Medicine, Division of Infectious Diseases, University Hospital, Linköping, Sweden.
    High concentration but low biological activity of hepatocyte growth factor in patients with chronic renal failure2012Ingår i: Advances in Bioscience and Biotechnology, ISSN 2156-8456, E-ISSN 2156-8502, Vol. 3, nr 4, s. 516-523Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Hepatocyte growth factor (HGF) is a renotropic, antifibrotic and regenerative factor with cytoprotective effects that is produced by mesenchymal cells and shows high affinity to components of extra cellular matrix, such as heparan sulphate proteoglycan (HS-PG), in healthy. Patients with chronic renal failure (CRF) suffer from a chronic inflammatory disorder. In order to assess the underlying mechanisms for development of CRF we aimed to assess the amounts and affinity of HGF in this patient group. Elisa, western blot and surface plasmon resonance (SPR) were used to study HGF in blood samples, as well as in isolated neutrophils, in CRF patients compared to healthy controls. Patients with CRF showed higher HGF levels in serum (P < 0.0001), but decreased affinity to HSPG (P < 0.0001), compared to healthy controls. Addition of protease inhibitors decreased the difference between patients with CRF compared to healthy individuals. HGF with potent regenerative function during injury lacks affinity to HSPG in patients with CRF that may depend on production of proteases from activated immune cells. This information might be used to highlight underlying mechanisms for chronicity and leading to new strategies for treatment of chronic injuries.

  • 257.
    Lönn, Johanna
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. PEAS Institute,Linköping, Sweden.
    Starkhammar Johansson, C.
    Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, sweden; Centre for Oral Rehabilitation, Public Dental Health Care, County Council of Östergötland, Linköping, Sweden.
    Kälvegren, H.
    Division of Clinical Pathology and Clinical Genetics, Linköping University, Faculty of Health Sciences, Linköping, Sweden.
    Brudin, L.
    Department of Medical and Health Sciences, University Hospital, Linköping, Sweden.
    Skoglund, C.
    Department of Medical and Health and Sciences, Division of Drug Research, Faculty of Health Sciences, Linköping University, Linköping, Sweden; Department of Physics, Chemistry and Biology, Division of Molecular Physics and Nanoscience, Linköping University, Linköping, Sweden.
    Garvin, P.
    Division of Community Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
    Särndahl, Eva
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Department ofCardiology, Örebro UniversityHospital, Örebro, Sweden.
    Ravald, N.
    Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; Centre for Oral Rehabilitation, Public Dental Health Care, County Council of Östergötland, Linköping, Sweden.
    Richter, A.
    Department of Cardiology, Heart Center, Linköping University Hospital, Linköping, Sweden.
    Bengtsson, Torbjörn
    Örebro universitet, Institutionen för läkarutbildning.
    Nayeri, F.
    PEAS Institute, Linköping, Sweden; Department of Molecular and Clinical Medicine, Division of Infectious Diseases, University Hospital, Linköping, Sweden.
    Hepatocyte growth factor in patients with coronary artery disease and its relation to periodontal condition2012Ingår i: Results in Immunology, ISSN 0105-1121, E-ISSN 2211-2839, Vol. 2, s. 7-12Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Hepatocyte growth factor (HGF) is an angiogenic, cardioprotective factor important for tissue and vascular repair. High levels of HGF are associated with chronic inflammatory diseases, such as coronary artery disease (CAD) and periodontitis, and are suggested as a marker of the ongoing atherosclerotic event in patients with CAD. Periodontal disease is more prevalent among patients with CAD than among healthy people. Recent studies indicate a reduced biological activity of HGF in different chronic inflammatory conditions. Biologically active HGF has high affinity to heparan sulfate proteoglycan (HSPG) on cell-membrane and extracellular matrix. The aim of the study was to investigate the serum concentration and the biological activity of HGF with ELISA and surface plasmon resonance (SPR), respectively, before and at various time points after percutaneous coronary intervention (PCI) in patients with CAD, and to examine the relationship with periodontal condition. The periodontal status of the CAD patients was examined, and the presence of P. gingivalis in periodontal pockets was analyzed with PCR. The HGF concentration was significantly higher, at all time-points, in patients with CAD compared to the age-matched controls (P< 0.001), but was independent of periodontal status. The HGF concentration and the affinity to HSPG adversely fluctuated over time, and the biological activity increased one month after intervention in patients without periodontitis. We conclude that elevated concentration of HGF but with reduced biological activity might indicate a chronic inflammatory profile in patients with CAD and periodontitis.

  • 258.
    Magnusdotter, Sofia
    Örebro universitet, Institutionen för läkarutbildning.
    Hypotermibehandling av nyfödda barn vid Universitetssjukhuset Örebro2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 259.
    Magnusson, Viktor
    Örebro universitet, Institutionen för läkarutbildning.
    Exponering för koboltpartiklar PM2.5 i hårdmetallindustri och inflammatoriska markörer2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 260.
    Malm, Kerstin
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Duberg, Ann-Sofi
    Örebro universitet, Institutionen för läkarutbildning.
    Sundqvist, Martin
    Fredlund, Hans
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Andersson, Sören
    Evaluation of a hepatitis C virus core antigen assay to monitor viral load in patients on antiviral therapy and in untreated patientsManuskript (preprint) (Övrigt vetenskapligt)
  • 261.
    Manouilenko, Irina
    et al.
    Järva Psychiatric Services, Praktikertjänst AB, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Bejerot, Susanne
    Örebro universitet, Institutionen för läkarutbildning. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Sukhareva-Prior to Asperger and Kanner2015Ingår i: Nordic Journal of Psychiatry, ISSN 0803-9488, E-ISSN 1502-4725, Vol. 69, nr 6, s. 1761-1764Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    As early as 1926, the Kiev-based child psychiatrist Grunya Efimovna Sukhareva (1891-1981) published a detailed description of autistic traits in a number of children in a scientific German psychiatry and neurology journal. She initially used the term schizoid (eccentric) psychopathy but later replaced it with autistic (pathological avoidant) psychopathy to describe the clinical picture of autism. Her original article was available almost two decades before the case reports of Asperger and Kanner; nevertheless, Sukhareva's pioneer work has been greatly overlooked. Here we present her description of autistic psychopathy in relation to the DSM-5 criteria of today.

  • 262. Marimuthu, Kanagaraj
    et al.
    Varadhan, Krishna K.
    Ljungqvist, Olle
    Örebro universitet, Institutionen för läkarutbildning.
    Lobo, Dileep N.
    A meta-analysis of the effect of combinations of immune modulating nutrients on outcome in patients undergoing major open gastrointestinal surgery2012Ingår i: Annals of Surgery, ISSN 0003-4932, E-ISSN 1528-1140, Vol. 255, nr 6, s. 1060-1068Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Immune modulating nutrition (IMN) has been shown to reduce complications after major surgery, but strong evidence to recommend its routine use is still lacking. Objective: The aim of this meta-analysis was to evaluate the impact of IMN combinations on postoperative infectious and noninfectious complications, length of hospital stay, and mortality in patients undergoing major open gastrointestinal surgery. Methods: Randomized controlled trials published between January 1980 and February 2011 comparing isocaloric and isonitrogenous enteral IMN combinations with standard diet in patients undergoing major open gastrointestinal surgery were included. The quality of evidence and strength of recommendation for each postoperative outcome were assessed using the GRADE approach and the outcome measures were analyzed with RevMan 5.1 software (Cochrane Collaboration, Copenhagen, Denmark). Results: Twenty-six randomized controlled trials enrolling 2496 patients (1252 IMN and 1244 control) were included. The meta-analysis suggests strong evidence in support of decrease in the incidence of postoperative infectious [risk ratio (RR) (95% confidence interval [CI]): 0.64 (0.55, 0.74)] and length of hospital stay [mean difference (95% CI): -1.88 (-2.91, -0.84 days)] in those receiving IMN. Even though significant benefit was observed for noninfectious complications [RR (95% CI): 0.82 (0.71, 0.95)], the quality of evidence was low. There was no statistically significant benefit on mortality [RR (95% CI): 0.83 (0.49, 1.41)]. Conclusions: IMN is beneficial in reducing postoperative infectious and noninfectious complications and shortening hospital stay in patients undergoing major open gastrointestinal surgery.

  • 263.
    Marttala, Jens
    Örebro universitet, Institutionen för läkarutbildning.
    Fetuin A and Free Fatty Acids Role in Transient Insulin Resistance and Increased Infection Sensitivity after Major Abdominal Surgery2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 264.
    Masarrat, Pooyan
    Örebro universitet, Institutionen för läkarutbildning.
    Prevalence of Extra-cardiac Atherosclerosis in Patients With Acute Coronary Syndrome – A Systematic Review2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 265.
    Mattsson, Johanna
    Örebro universitet, Institutionen för läkarutbildning.
    Ett livsviktigt beslut om livet – Läkares och sjuksköterskors ställningstagande samt upplevelser kring 0-HLR.2014Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 266.
    Mattsson, Johanna S. M.
    et al.
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
    Bergman, Bengt
    Department of Respiratory Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Grinberg, Marianna
    Department of Statistics, TU Dortmund University, Dortmund, Germany.
    Edlund, Karolina
    Leibniz Research Centre for Working Environment and Human Factors (IfADo), TU Dortmund University, Dortmund, Germany.
    Marincevic, Millaray
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
    Jirström, Karin
    Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden.
    Pontén, Fredrik
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
    Hengstler, Jan G.
    Leibniz Research Centre for Working Environment and Human Factors (IfADo), TU Dortmund University, Dortmund, Germany.
    Rahnenführer, Joerg
    Department of Statistics, TU Dortmund University, Dortmund, Germany.
    Karlsson, Mats G.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Region Örebro län. Department of Pathology, Örebro University Hospital, Örebro, Sweden.
    Karlsson, Christina
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Pathology, Örebro University Hospital, Örebro University, Örebro, Sweden.
    Helenius, Gisela
    Örebro universitet, Institutionen för läkarutbildning. Region Örebro län. Department of Pathology, Örebro University Hospital, Örebro, Sweden.
    Botling, Johan
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
    Micke, Patrick
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
    Gulyas, Miklos
    Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
    Prognostic impact of COX-2 in non-small cell lung cancer: a comprehensive compartment-specific evaluation of tumor and stromal cell expression2015Ingår i: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 356, nr 2, s. 837-845Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Cyclooxygenase-2 (COX-2) is an enzyme that has been extensively investigated as a prognostic marker in cancer. In non-small cell lung cancer (NSCLC) previous results regarding the prognostic impact of COX-2 expression are inconsistent. Therefore we evaluated the association between transcript levels and overall survival in nine publicly available gene expression data sets (total n = 1337) and determined in situ compartment-specific tumor and stromal cell protein expression in two independent cohorts (n = 616). Gene expression did not show any correlation with clinical parameters or with overall survival. Protein expression in tumor and stromal cells did not correlate with any clinical parameter or with overall survival in one of the analyzed cohorts, while a significant association of high stromal expression with longer survival was observed in both univariate and multivariate analysis in the other cohort. Stromal expression of COX-2 has not been separately evaluated in NSCLC previously and may be a subject of further investigation, whereas the presented findings from this comprehensive compartment specific evaluation clearly reject the hypothesis of COX-2 tumor cell expression having a prognostic value in NSCLC. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

  • 267.
    Mattsson, Johanna S. M.
    et al.
    Dept Immunol Genet & Pathol, Uppsala Univ, Uppsala, Sweden.
    Svensson, Maria A.
    Institutionen för hälsovetenskap och medicin, Department of Pathology, Örebro universitet, Örebro, Sweden.
    Hallström, Bjorn
    Sci Life Lab, KTH Royal Inst Technol, Stockholm, Sweden.
    Koyi, Hirsh
    Dept Resp Med, Gävle Cent Hosp, Gävle, Sweden.
    Branden, Eva
    Dept Resp Med, Gävle Cent Hosp, Gävle, Sweden.
    Brunnström, Hans
    Dept Clin Sci Lund, Div Oncol & Pathol, Lund Univ, Lund, Sweden.
    Edlund, Karolina
    Leibniz Res Ctr Working Environm & Human Factors, Dortmund TU, Dortmund, Germany.
    Ekman, Simon
    Dept Immunol Genet & Pathol, Uppsala Univ, Uppsala, Sweden.
    La Fleur, Linnea
    Dept Immunol Genet & Pathol, Uppsala Univ, Uppsala, Sweden.
    Grinberg, Marianna
    Dept Stat, Dortmund TU, Dortmund, Germany.
    Rahnenfuehrer, Joerg
    Dept Stat, Dortmund TU, Dortmund, Germany.
    Jirström, Karin
    Dept Clin Sci Lund, Div Oncol & Pathol, Lund Univ, Lund, Sweden.
    Ponten, Fredrik
    Dept Immunol Genet & Pathol, Uppsala Univ, Uppsala, Sweden.
    Karlsson, Mats G.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Pathology, Örebro University Hospital, Örebro, Sweden.
    Karlsson, Christina
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Pathology, Örebro University Hospital, Örebro, Sweden.
    Helenius, Gisela
    Örebro universitet, Institutionen för läkarutbildning. Department of Pathology, Örebro University Hospital, Örebro, Sweden.
    Uhlen, Mathias
    Sci Life Lab, KTH Royal Inst Technol, Stockholm, Sweden.
    Botling, Johan
    Dept Immunol Genet & Pathol, Uppsala Univ, Uppsala, Sweden.
    Micke, Patrick
    Dept Immunol Genet & Pathol, Uppsala Univ, Uppsala, Sweden.
    ALK Rearrangements in Non-Small Cell Lung Cancer: Comprehensive Integration of Genomic, Gene Expression and Protein Analysis2015Ingår i: Journal of Thoracic Oncology, ISSN 1556-0864, E-ISSN 1556-1380, Vol. 10, nr 9, s. S298-S298Artikel i tidskrift (Övrigt vetenskapligt)
  • 268.
    Mauritzson, Daniel
    Örebro universitet, Institutionen för läkarutbildning.
    A Pilot study of the relationship between overhydration, inflammation and cardiac biomarkers in hemodialysis patients2014Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 269. McGovern, Dermot P. B.
    et al.
    Gardet, Agnes
    Törkvist, Leif
    Goyette, Philippe
    Essers, Jonah
    Taylor, Kent D.
    Neale, Benjamin M.
    Ong, Rick T. H.
    Lagace, Caroline
    Li, Chun
    Green, Todd
    Stevens, Christine R.
    Beauchamp, Claudine
    Fleshner, Phillip R.
    Carlson, Marie
    D'Amato, Mauro
    Halfvarson, Jonas
    Örebro universitet, Institutionen för läkarutbildning.
    Hibberd, Martin L.
    Loerdal, Mikael
    Padyukov, Leonid
    Andriulli, Angelo
    Colombo, Elisabetta
    Latiano, Anna
    Palmieri, Orazio
    Bernard, Edmond-Jean
    Deslandres, Colette
    Hommes, Daan W.
    de Jong, Dirk J.
    Stokkers, Pieter C.
    Weersma, Rinse K.
    Sharma, Yashoda
    Silverberg, Mark S.
    Cho, Judy H.
    Wu, Jing
    Roeder, Kathryn
    Brant, Steven R.
    Schumm, L. Phillip
    Duerr, Richard H.
    Dubinsky, Marla C.
    Glazer, Nicole L.
    Haritunians, Talin
    Ippoliti, Andy
    Melmed, Gil Y.
    Siscovick, David S.
    Vasiliauskas, Eric A.
    Targan, Stephan R.
    Annese, Vito
    Wijmenga, Cisca
    Pettersson, Sven
    Rotter, Jerome I.
    Xavier, Ramnik J.
    Daly, Mark J.
    Rioux, John D.
    Seielstad, Mark
    Genome-wide association identifies multiple ulcerative colitis susceptibility loci (vol 42, pg 332, 2010)2011Ingår i: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 43, nr 4, s. 388-388Artikel i tidskrift (Refereegranskat)
  • 270.
    Mekkes, M. C.
    et al.
    Athena Inst, Vrije Univ, Amsterdam, Netherlands.
    Weenen, T. C.
    Erasmus Sch Econ Rotterdam, Erasmus Universiteit Rotterdam, Rotterdam, Netherlands; Erasmus MC, Rotterdam, Netherlands.
    Brummer, Robert J.
    Örebro universitet, Institutionen för läkarutbildning. Region Örebro län.
    Claassen, E.
    Athena Inst, Vrije Univ, Amsterdam, the Netherlands; Erasmus MC Rotterdam, Rotterdam, Netherlands.
    The development of probiotic treatment in obesity: a review2014Ingår i: Beneficial Microbes, ISSN 1876-2883, E-ISSN 1876-2891, Vol. 5, nr 1, s. 19-28Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Recent studies suggested that manipulation of the composition of the microbial ecosystem in the gut might be a novel approach in the treatment of obesity. Such treatment might consist of altering the composition of the microbial communities of an obese individual by administration of beneficial microorganisms, commonly known as probiotics. Here, we intend to contribute to the developmental process of probiotic treatment of human obesity. The aim is to review the evidence regarding the potential effect of probiotic strains on reduction of weight and body fat. A literature study was conducted focusing on clinical trials that examined the effect of specific microorganisms on body weight control. Analysis of the eligible articles pointed out that Lactobacillus gasseri SBT 2055, Lactobacillus rhamnosus ATCC 53103, and the combination of L. rhamnosus ATCC 53102 and Bifidobacterium lactis Bb12 may reduce adiposity, body weight, and weight gain. This suggests that these microbial strains can be applied in the treatment of obesity. Furthermore, short chain fatty acid production and low grade inflammation were found as the underlying mechanisms of action that influence metabolism and affect body weight. These findings might contribute to the development of probiotic treatment of obesity. Further research should be directed to the most effective combination and dosage rate of probiotic microorganisms.

  • 271.
    Melander, Emma
    Örebro universitet, Institutionen för läkarutbildning.
    Metabolic Control in Type 2-Diabetes Mellitus – Effects of Physical Activity and Smoking2014Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 272.
    Melander, Nils
    Örebro universitet, Institutionen för läkarutbildning.
    Effect of graft selection on the incidence of infection, DVT and contralateral ACL rupture after arthroscopically assisted ACL reconstruction: a retrospective study2014Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 273.
    Melik, Wessam
    et al.
    School of Life Sciences, Södertörn University, Huddinge, Sweden.
    Ellencrona, Karin
    School of Life Sciences, Södertörn University, Huddinge, Sweden.
    Wigerius, Michael
    School of Life Sciences, Södertörn University, Huddinge, Sweden; Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax NS, Canada.
    Hedström, Christer
    School of Life Sciences, Södertörn University, Huddinge, Sweden.
    Elväng, Annelie
    School of Life Sciences, Södertörn University, Huddinge, Sweden.
    Johansson, Magnus
    Örebro universitet, Institutionen för läkarutbildning. School of Life Sciences, Södertörn University, Huddinge, Sweden.
    Two PDZ binding motifs within NS5 have roles in Tick-borne encephalitis virus replication2012Ingår i: Virus Research, ISSN 0168-1702, E-ISSN 1872-7492, Vol. 169, nr 1, s. 54-62Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The flavivirus genus includes important human neurotropic pathogens like Tick-borne encephalitis virus (TBEV) and West-Nile virus (WNV). Flavivirus replication occurs at replication complexes, where the NS5 protein provides both RNA cap methyltransferase and RNA-dependent RNA polymerase activities. TBEVNS5 contains two PDZ binding motifs (PBMs) important for specific targeting of human PDZ proteins including Scribble, an association important for viral down regulation of cellular defense systems and neurite outgrowth. To determine whether the PBMs of TBEVNS5 affects virus replication we constructed a DNA based sub-genomic TBEV replicon expressing firefly luciferase. The PBMs within NS5 were mutated individually and in concert and the replicons were assayed in cell culture. Our results show that the replication rate was impaired in all mutants, which indicates that PDZ dependent host interactions influence TBEV replication. We also find that the C-terminal PBMs present in TBEVNS5 and WNVNS5 are targeting various human PDZ domain proteins. TBEVNS5 has affinity to Zonula occludens-2 (ZO-2), GIAP C-terminus interacting protein (GIPC), calcium/calmodulin-dependent serine protein kinase (CASK), glutamate receptor interacting protein 2, (GRIP2) and Interleukin 16 (IL-16). A different pattern was observed for WNVNS5 as it associate with a broader repertoire of putative host PDZ proteins.

  • 274.
    Melinder, Carren
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
    Hiyoshi, Ayako
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
    Halfvarson, Jonas
    Örebro universitet, Institutionen för läkarutbildning. Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
    Montgomery, Scott
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, UK.
    Stress resilience in adolescence and subsequent inflammatory bowel disease risk in adulthood2015Ingår i: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 61, s. 27-27Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [en]

    Objective: Psychosocial stress may increase the risk of systemic inflammation. As subclinical inflammatory bowel disease (IBD) – Crohn's disease (CD) and ulcerative colitis (UC) – can exist over many years, stress may result in conversion to symptomatic disease through its inflammatory influence. Low stress resilience may result in a greater risk of chronic stress arousal due to the normal stresses of everyday life. We investigated the association of stress resilience in adolescence with subsequent risk of IBD, independent of other risks.

    Design: Swedish registers provided information on 242,999 men who underwent military conscription assessments in late adolescence (1969 – 1976) with follow-up until 2009 (up to age 57 years). Stress resilience was evaluated through semi-structured interviews. Cox regression assessed the association of stress resilience with CD (n = 1,082) and UC (1,922) in separate models. The models included adjustment for socioeconomic characteristics in childhood and height, BMI and erythrocyte sedimentation rate (indicating inflammation) as indicators of subclinical disease activity in adolescence.

    Results: Low stress resilience in adolescence was associated with increased risk of IBD after adjustment for potential confounding factors, with hazard ratios (95% confidence intervals) of 1.50 (1.24-1.81) and 1.21 (1.06-1.39), for CD and UC respectively. The associations attenuated somewhat by further adjustment for markers of subclinical disease to 1.38 (1.14-1.67) and 1.19 (1.04-1.36).

    Conclusions: low stress resilience is associated with an elevated subsequent IBD risk. Stress may increase the risk of symptomatic IBD, although there is also evidence of a potentially modest effect of subclinical disease activity on stress resilience.

  • 275.
    Melinder, Carren
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Hiyoshi, Ayako
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Hussein, Oula
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Halfvarson, Jonas
    Örebro universitet, Institutionen för läkarutbildning. Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
    Ekbom, Anders
    Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
    Montgomery, Scott
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, UK.
    Physical Fitness in Adolescence and Subsequent Inflammatory Bowel Disease Risk2015Ingår i: Clinical and Translational Gastroenterology, ISSN 2155-384X, E-ISSN 2155-384X, Vol. 6, artikel-id e121Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objectives: Physical fitness may reduce systemic inflammation levels relevant to the risk of symptomatic Crohn's disease (CD) and ulcerative colitis (UC); we assessed if fitness in adolescence is associated with subsequent inflammatory bowel disease (IBD) risk, independent of markers of risk and prodromal disease activity.

    Methods: Swedish registers provided information on a cohort of 240,984 men (after exclusions) who underwent military conscription assessments in late adolescence (1969-1976). Follow-up started at least 4 years after the conscription assessment until 31 December 2009 (up to age 57 years). Cox's regression assessed the association of physical fitness with CD (n=986) and UC (n=1,878) in separate models, with adjustment including: socioeconomic conditions in childhood; physical fitness, height, body mass index, and erythrocyte sedimentation rate (ESR) in adolescence; and subsequent diagnoses of IBD.

    Results: Low fitness was associated with a raised risk of IBD, with unadjusted hazard ratios (and 95% confidence intervals) of 1.62 (1.31-2.00) for CD and 1.36 (1.17-1.59) for UC. The results were attenuated by adjustment, particularly for markers of prodromal disease activity to 1.32 (1.05-1.66) and 1.25 (1.06-1.48), respectively. Raised ESR in adolescence was associated with increased risks for subsequent CD (5.95 (4.47-7.92)) and UC (1.92 (1.46-2.52)).

    Conclusions: The inverse association of physical fitness with IBD risk is consistent with a protective role for exercise. However, evidence of disease activity before diagnosis was already present in adolescence, suggesting that some or all of the association between fitness and IBD may be due to prodromal disease activity reducing exercise capacity and therefore fitness.

  • 276.
    Melinder, Carren
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Udumyan, Ruzan
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Hiyoshi, Ayako
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Brummer, Robert Jan
    Örebro universitet, Institutionen för läkarutbildning.
    Montgomery, Scott
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, United Kingdom .
    Decreased stress resilience in young men significantly increases the risk of subsequent peptic ulcer disease: a prospective study of 233 093 men in Sweden2015Ingår i: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 41, nr 10, s. 1005-1015Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Psychosocial stress may influence peptic ulcer disease (PUD) risk, but it can be difficult to identify reliably whether stressful exposures pre-dated disease. The association of stress resilience (susceptibility to stress) with subsequent PUD risk has been incompletely investigated.

    AIM: To assess if stress resilience in adolescence is associated with subsequent PUD risk.

    METHODS: The participants comprised of 233 093 men resident in Sweden, born 1952-1956 and assessed for compulsory military conscription during 1969-1976, with data provided by national Swedish registers. Stress resilience was evaluated through semi-structured interviews by a certified psychologist. Cox regression assessed the association between stress resilience in adolescence and the risk of PUD from 1985 to 2009, between ages 28 and 57 years, with adjustment for parental socioeconomic index, household crowding and number of siblings in childhood, as well as cognitive function and erythrocyte sedimentation rate in adolescence.

    RESULTS: In total, 2259 first PUD diagnoses were identified. Lower stress resilience in adolescence is associated with a higher risk of PUD in subsequent adulthood: compared with high resilience, the adjusted hazard ratios (and 95% CI) are 1.84 (1.61-2.10) and 1.23 (1.09-1.38) for low and moderate stress resilience, respectively.

    CONCLUSION: Stress may be implicated in the aetiology of PUD and low stress resilience is a marker of risk.

  • 277.
    Meng, Wen-Jian
    et al.
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China; Department of Oncology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
    Pathak, Surajit
    Department of Oncology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
    Ding, Zhen-Yu
    Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
    Zhang, Hong
    Örebro universitet, Institutionen för läkarutbildning.
    Adell, Gunnar
    Department of Oncology, County Council of Östergötland, Linköping, Sweden.
    Holmlund, Birgitta
    Department of Oncology, County Council of Östergötland, Linköping, Sweden.
    Li, Yuan
    Institute of Digestive Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
    Zhou, Zong-Guang
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China; Institute of Digestive Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
    Sun, Xiao-Feng
    Department of Oncology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden; Institute of Digestive Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
    Special AT-rich sequence binding protein 1 expression correlates with response to preoperative radiotherapy and clinical outcome in rectal cancer2015Ingår i: Cancer Biology & Therapy, ISSN 1538-4047, E-ISSN 1555-8576, Vol. 16, nr 12, s. 1738-1745Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Our recent study showed the important role of special AT-rich sequence binding protein 1 (SATB1) in the progression of human rectal cancer. However, the value of SATB1 in response to radiotherapy (RT) for rectal cancer hasn't been reported so far. Here, SATB1 was determined using immunohistochemistry in normal mucosa, biopsy, primary cancer, and lymph node metastasis from 132 rectal cancer patients: 66 with and 66 without preoperative RT before surgery. The effect of SATB1 knockdown on radiosensitivity was assessed by proliferation-based assay and clonogenic assay. The results showed that SATB1 increased from normal mucosa to primary cancer, whereas it decreased from primary cancer to metastasis in non-RT patients. SATB1 decreased in primary cancers after RT. In RT patients, positive SATB1 was independently associated with decreased response to preoperative RT, early time to metastasis, and worse survival. SATB1 negatively correlated with ataxia telangiectasia mutated (ATM) and pRb2/p130, and positively with Ki-67 and Survivin in RT patients, and their potential interaction through different canonical pathways was identified in network ideogram. Taken together, our findings disclose for the first time that radiation decreases SATB1 expression and sensitizes cancer cells to confer clinical benefit of patients, suggesting that SATB1 is predictive of response to preoperative RT and clinical outcome in rectal cancer.

  • 278.
    Meng, Wen-Jian
    et al.
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
    Yang, Lie
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
    Ma, Qin
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
    Zhang, Hong
    Örebro universitet, Institutionen för läkarutbildning.
    Adell, Gunnar
    Department of Oncology, County Council of Ostergötland, Linköping, Sweden.
    Arbman, Gunnar
    Department of Surgery, Vrinnevi Hospital, University of Linköping, Norrköping, Sweden.
    Wang, Zi-Qiang
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
    Li, Yuan
    State Key Lab Biotherapy, Inst Digest Surg, West China Hosp, Sichuan Univ, Chengdu, Peoples R China; Ctr Canc, West China Hosp, Sichuan Univ, Chengdu, Peoples R China.
    Zhou, Zong-Guang
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China; State Key Lab Biotherapy, Inst Digest Surg, West China Hosp, Sichuan Univ, Chengdu, Peoples R China; Ctr Canc, West China Hosp, Sichuan Univ, Chengdu, Peoples R China.
    Sun, Xiao-Feng
    State Key Lab Biotherapy, Inst Digest Surg, West China Hosp, Sichuan Univ, Chengdu, Peoples R China; Ctr Canc, West China Hosp, Sichuan Univ, Chengdu, Peoples R China; Department of Oncology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
    MicroRNA Expression Profile Reveals miR-17-92 and miR-143-145 Cluster in Synchronous Colorectal Cancer2015Ingår i: Medicine (Baltimore, Md.), ISSN 0025-7974, E-ISSN 1536-5964, Vol. 94, nr 32Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The expression of abnormal microRNA (miRNA, miR) is a ubiquitous feature of colorectal cancer (CRC). The pathological features and clinical behaviors of synchronous CRC have been comprehensively described; however, the expression profile of miRNA and small nucleolar RNA (snoRNA) in synchronous CRC has not been elucidated. In the present study, the expression profile of miRNA and snoRNA in 5 synchronous CRCs, along with the matched normal colorectal tissue was evaluated by microarray. Function and pathway analyses of putative targets, predicted from miRNA-mRNA interaction, were performed. Moreover, we analyzed clinicopathological and molecular characteristics of 22 patients with synchronous CRC and 579 solitary CRCs in a retrospective cohort study. We found a global dysregulation of miRNAs, including an oncogenic miR-17-92 cluster and oncosuppressive miR-143-145 cluster, and snoRNAs in synchronous CRC. Differential miRNA rather than snoRNA expression was robust enough to distinguish synchronous cancer from normal mucosa. Function analysis of putative targets suggested that miRNA clusters may modulate multiple effectors of oncogenic pathways involved in the pathogenesis of synchronous CRC. A comparison of normal mucosa between synchronous and solitary CRC suggested a differential genetic background of synchronous CRC from solitary CRC during carcinogenesis. Compared with solitary cancer patients, synchronous cases exhibited multiple extra-colonic cancers (P=0.012), coexistence of adenoma (P=0.012), microsatellite instability (P=0.024), and less glucose transporter 1 (P=0.037). Aberrant miRNA expression profiles could potentially be used as a diagnostic tool for synchronous CRC. Our findings represent the first comprehensive miRNA and snoRNA expression signatures for synchronous CRC, implicating that the miRNAs and snoRNAs may present therapeutic targets for synchronous CRC.

  • 279.
    Mohajerpour, Martin
    Örebro universitet, Institutionen för läkarutbildning.
    Plasma levels of parathyroid hormone and their relationship to 25- hydroxyvitamin D and attention deficit hyperactivity disorder2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 280.
    Mohammed, Ahmed
    Örebro universitet, Institutionen för läkarutbildning.
    Kvalitetsgranskning av preoperativ luftvägsbedömning2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 281.
    Mohseni, Shahin
    et al.
    Region Örebro län. Department of Surgery, Division of Acute Care Surgery, Örebro University Hospital, Örebro, Sweden; Örebro University, Örebro, Sweden; Department of Surgery, Division of Acute Care Surgery and Trauma, Karolinska University Hospital Solna, Stockholm, Sweden.
    Talving, Peep
    Department of Surgery, Tartu University Hospital, Tartu, Estonia; Department of Surgery, North Estonia Medical Center, Tallinn, Estonia.
    Thelin, Eric P.
    Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.
    Wallin, Göran
    Region Örebro län. Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Surgery, Division of Acute Care Surgery, Örebro University Hospital, Örebro, Sweden.
    Ljungqvist, Olle
    Örebro universitet, Institutionen för läkarutbildning. Region Örebro län. Department of Surgery, Division of Acute Care Surgery, Örebro University Hospital, Örebro, Sweden.
    Riddez, Louis
    Department of Surgery, Division of Acute Care Surgery and Trauma, Karolinska University Hospital Solna, Stockholm, Sweden.
    The Effect of beta-blockade on Survival After Isolated Severe Traumatic Brain Injury2015Ingår i: World Journal of Surgery, ISSN 0364-2313, E-ISSN 1432-2323, Vol. 39, nr 8, s. 2076-2083Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Several North American studies have observed survival benefit in patients exposed to beta-blockers following traumatic brain injury (TBI). The purpose of this study was to evaluate the effect of beta-blockade on mortality in a Swedish cohort of isolated severe TBI patients.

    The trauma registry of an urban academic trauma center was queried to identify patients with an isolated severe TBI between 1/2007 and 12/2011. Isolated severe TBI was defined as an intracranial injury with an Abbreviated Injury Scale (AIS) a parts per thousand yen3 excluding extra-cranial injuries AIS a parts per thousand yen3. Multivariable logistic regression analysis was used to determine the effect of beta-blocker exposure on mortality. Also, a subgroup analysis was performed to investigate the risk of mortality in patients on pre-admission beta-blocker versus not and the effect of specific type of beta-blocker on the overall outcome.

    Overall, 874 patients met the study criteria. Of these, 33 % (n = 287) were exposed to beta-blockers during their hospital admission. The exposed patients were older (62 +/- A 16 years vs. 49 +/- A 21 years, p < 0.001), and more severely injured based on their admission GCS, ISS, and head AIS scores (GCS a parts per thousand currency sign8: 32 % vs. 28 %, p = 0.007; ISS a parts per thousand yen16: 71 % vs. 59 %, p = 0.001; head AIS a parts per thousand yen4: 60 % vs. 45 %, p < 0.001). The crude mortality was higher in patients who did not receive beta-blockers (17 % vs. 11 %, p = 0.007) during their admission. After adjustment for significant confounders, the patients not exposed to beta-blockers had a 5-fold increased risk of in-hospital mortality (AOR 5.0, CI 95 % 2.7-8.5, p = 0.001). No difference in survival was noted in regards to the type of beta-blocker used. Subgroup analysis revealed a higher risk of mortality in patients naive to beta-blockers compared to those on pre-admission beta-blocker therapy (AOR 3.0 CI 95 % 1.2-7.1, p = 0.015).

    Beta-blocker exposure after isolated severe traumatic brain injury is associated with significantly improved survival. We also noted decreased mortality in patients on pre-admission beta-blocker therapy compared to patients naive to such treatment. Further prospective studies are warranted.

  • 282.
    Månsson, Emeli
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Centre for Clinical Research, Uppsala University, Uppsala, Sweden; County Hospital, Västerås, Sweden.
    Hellmark, Bengt
    Region Örebro län. Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden.
    Sundqvist, Martin
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Söderquist, Bo
    Örebro universitet, Institutionen för läkarutbildning.
    Sequence types of Staphylococcus epidermidis associated with prosthetic joint infections are not present in the laminar airflow during prosthetic joint surgery2015Ingår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 123, nr 7, s. 589-595Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Molecular characterization of Staphylococcus epidermidis isolates from prosthetic joint infections (PJIs) has demonstrated a predominance of healthcare-associated multi-drug resistant sequence types (ST2 and ST215). How, and when, patients acquire these nosocomial STs is not known. The aim was to investigate if sequence types of S. epidermidis associated with PJIs are found in the air during prosthetic joint surgery. Air sampling was undertaken during 17 hip/knee arthroplasties performed in operating theaters equipped with mobile laminar airflow units in a 500-bed hospital in central Sweden. Species identification was performed using MALDI-TOF MS and 16S rRNA gene analysis. Isolates identified as S. epidermidis were further characterized by MLST and antibiotic susceptibility testing. Seven hundred and thirty-five isolates were available for species identification. Micrococcus spp. (n = 303) and coagulase-negative staphylococci (n = 217) constituted the majority of the isolates. Thirty-two isolates of S. epidermidis were found. S. epidermidis isolates demonstrated a high level of allelic diversity with 18 different sequence types, but neither ST2 nor ST215 was found. Commensals with low pathogenic potential dominated among the airborne microorganisms in the operating field during prosthetic joint surgery. Nosocomial sequence types of S. epidermidis associated with PJIs were not found, and other routes of inoculation are therefore of interest in future studies.

  • 283.
    Mårdberg, Emelie
    Örebro universitet, Institutionen för läkarutbildning.
    Effect of Resistance Training in Patients with Type 2 Diabetes Mellitus: − A Systematic Review2014Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 284.
    Möller, Sigrid
    Örebro universitet, Institutionen för läkarutbildning.
    Prevalence of lactose fermenting and non-lactose fermenting Escherichia coli in faecal samples of healthy individuals2014Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 285.
    Nakka, Sravya Sowdamini
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. The Institution for Protein Environmental Affinity Surveys, PEAS Institut AB, Linköping, Sweden.
    Lönn, Johanna
    Örebro universitet, Institutionen för hälsovetenskap och medicin. The Institution for Protein Environmental Affinity Surveys, PEAS Institut AB, Linköping, Sweden.
    Starkhammar Johansson, Carin
    Centre for Oral Rehabilitation, Public Dental Health Care, County Council of Östergötland, Linköping, Sweden.
    Bengtsson, Torbjörn
    Örebro universitet, Institutionen för läkarutbildning.
    Nayeri, Fariba
    The Institution for Protein Environmental Affinity Surveys, PEAS Institut AB, Linköping, Sweden; Division of Infectious Diseases, University Hospital, Linköping, Sweden.
    Antibodies produced in vitro in the detection of periodontal bacteria by using surface plasmon resonance analysis2015Ingår i: Clinical and Experimental Dental Research, ISSN 2057-4347, Vol. 1, nr 1, s. 32-44Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Porphyromonas gingivalis (P. gingivalis) is a major etiological agent associated with periodontitis. This study aims to develop antibodies to P. gingivalis in vitro for real-time detection of bacteria in clinical samples. Lymphocytes were isolated from whole blood of patient treated for periodontitis and were stimulated with P. gingivalis ATCC 33277. B-cell maturation to long-living antibody secreting-plasma cells was studied using flow cytometry and immunofluorescence staining. The antibodies developed in vitro were immobilized onto a CM-5 sensor chip of a biosensor to detect the presence of P. gingivalis in the gingival crevicular fluid of patients with periodontitis compared to periodontally healthy controls (n = 30). Surface plasmon resonance (SPR) analysis was performed to evaluate specific interactions of bacteria in samples with the immobilized antibodies. The results of SPR analysis were compared to the detection of P. gingivalis in the samples using DNA–DNA checkerboard hybridization technique. A clear and distinct change in lymphocyte morphology upon stimulation with P. gingivalis was observed. Anti-P. gingivalis antibodies secreted by CD38+ plasma cells showed the presence of all the four IgG subclasses. The results of DNA–DNA checkerboard analysis were in agreement with that of SPR analysis for the detection of P. gingivalis in patient samples. Furthermore, incubation with anti-P. gingivalis attenuated the bacterial response in SPR. The in vitro method for antibody production developed during this study could be used for an efficient real-time detection of periodontitis, and the attenuating effects of in vitro antibodies suggest their role in passive immunization to prevent periodontitis and their associated risk factors.

  • 286.
    Nelson, G.
    et al.
    Department of Gynecologic Oncology, Tom Baker Cancer Centre, Calgary AB, Canada.
    Altman, A. D.
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg MB, Canada.
    Nick, A.
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston TX, USA.
    Meyer, L. A.
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston TX, USA.
    Ramirez, P. T.
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston TX, USA.
    Achtari, C.
    Department of Obstetrics and Gynecology, Lausanne University Hospital, Lausanne, Switzerland.
    Antrobus, J.
    Department of Anesthesiology, Borders General Hospital, Melrose, United Kingdom.
    Huang, J.
    Anesthesiologists of Greater Orlando, Orlando FL, USA.
    Scott, M.
    Department of Anaesthesia and Intensive Care Medicine, Royal Surrey County NHS Foundation Hospital, Guildford, United Kingdom; Surrey Peri-operative Anaesthesia Critical Care Research group (SPACeR) Clinical Academic Group, FHMS, University of Surrey, Guildford, United Kingdom.
    Wijk, Lena
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Obstetrics and Gynecology, Örebro University Hospital, Örebro, Sweden.
    Acheson, N.
    Department of Gynaecologic Oncology, Royal Devon & Exeter NHS Foundation Trust, Exeter, United Kingdom.
    Ljungqvist, Olle
    Örebro universitet, Institutionen för läkarutbildning. Department of Surgery, Örebro University Hospital, Örebro, Sweden.
    Dowdy, S. C.
    Division of Gynecologic Surgery, Mayo Clinic College of Medicine, Rochester MN, USA.
    Guidelines for postoperative care in gynecologic/oncology surgery: Enhanced Recovery After Surgery (ERAS (R)) Society recommendations - Part II2016Ingår i: Gynecologic Oncology, ISSN 0090-8258, E-ISSN 1095-6859, Vol. 140, nr 2, s. 323-332Artikel i tidskrift (Refereegranskat)
  • 287.
    Nelson, G.
    et al.
    Department of Gynecologic Oncology, Tom Baker Cancer Centre, Calgary, Alberta, Canada.
    Altman, A. D.
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg MB, Canada.
    Nick, A.
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston TX, United States.
    Meyer, L. A.
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston TX, United States.
    Ramirez, P. T.
    Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston TX, United States.
    Achtari, C.
    Department of Obstetrics and Gynecology, Lausanne University Hospital, Lausanne, Switzerland.
    Antrobus, J.
    Department of Anesthesiology, Borders General Hospital, Melrose, United Kingdom.
    Huang, J.
    Anesthesiologists of Greater Orlando, Orlando FL, United States.
    Scott, M.
    Department of Anaesthesia and Intensive Care Medicine, Royal Surrey County NHS Foundation Hospital, Guildford, United Kingdom; Surrey Peri-operative Anaesthesia Critical Care Research group (SPACeR), Clinical Academic Group, FHMS, University of Surrey, Guildford, United Kingdom.
    Wijk, Lena
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Obstetrics and Gynecology,, Örebro University Hospital, Örebro, Sweden.
    Acheson, N.
    Department of Gynaecologic Oncology, Royal Devon & Exeter NHS Foundation Trust, Exeter, United Kingdom.
    Ljungqvist, Olle
    Örebro universitet, Institutionen för läkarutbildning. Department of Surgery, Örebro University Hospital, Örebro, Sweden.
    Dowdy, S. C.
    Division of Gynecologic Surgery, Mayo Clinic College of Medicine, Rochester MN, United States.
    Guidelines for pre- and intra-operative care in gynecologic/oncology surgery: Enhanced Recovery After Surgery (ERAS (R)) Society recommendations - Part I2016Ingår i: Gynecologic Oncology, ISSN 0090-8258, E-ISSN 1095-6859, Vol. 140, nr 2, s. 313-322Artikel i tidskrift (Refereegranskat)
  • 288.
    Nestor, David
    Örebro universitet, Institutionen för läkarutbildning.
    Evaluating Multiplex PCR in the diagnostics of CNS infections2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 289.
    Nilsagård, Ylva
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Ctr Hlth Care Sci, Örebro Univ Hosp, Örebro, Sweden.
    Westerdahl, Elisabeth
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Wittrin, A.
    Gunnarsson, Martin
    Örebro universitet, Institutionen för läkarutbildning.
    Correlation between maximal walking distance and self-rated limitations in walking2014Ingår i: Multiple Sclerosis, ISSN 1352-4585, E-ISSN 1477-0970, Vol. 20, nr 7, s. 992-992Artikel i tidskrift (Övrigt vetenskapligt)
  • 290.
    Nilsagård, Ylva
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Westerdahl, Elisabeth
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Wittrin, Anna
    Department of Neurology, Örebro University Hospital, Örebro, Sweden.
    Gunnarsson, Martin
    Örebro universitet, Institutionen för läkarutbildning. Department of Neurology, Örebro University Hospital, Örebro, Sweden.
    Walking Distance as a Predictor of Falls in People With Multiple Sclerosis2016Ingår i: Physiotherapy Research International, ISSN 1358-2267, E-ISSN 1471-2865, Vol. 21, nr 2, s. 102-108Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background and purpose: People with multiple sclerosis (PwMS) experience falls, usually when walking and transferring. The aim was to investigate if walking distance and patient overestimate of walking distance are predictors of falls in PwMS.

    Methods: A prospective study was conducted, with a single test occasion followed by prospective registration of falls for 3 months. All PwMS in Region Örebro County with a previously registered Expanded Disability Status Scale score between 3.0 and 7.0 in the Swedish MS Registry were invited to participate (n = 149). Altogether, data from 49 PwMS being relapse free for at least 3 months and with a confirmed Expanded Disability Status Scale between 1.5 and 7.0 upon study entry were analysed.

    Results: Twenty-two PwMS (45%) fell during the study period, providing information of 66 falls. Walking distance or overestimate of one's walking distance, as compared with test results, did not predict falls in this MS sample.

    Discussion: Walking and standing activities are associated with numerous falls in PwMS. Our data do not clearly support routine measurements of walking distance in assessing individual fall risk.

  • 291.
    Nilsson, Carolina
    Örebro universitet, Institutionen för läkarutbildning.
    Brain metastases in patients with breast cancer (BCBM)2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 292.
    Nilsson, Fredrik
    Örebro universitet, Institutionen för läkarutbildning.
    Has the sensitivity of sentinel node analysis in penile cancer improved ?2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 293.
    Norberg, Julian
    Örebro universitet, Institutionen för läkarutbildning.
    TIA som riskfaktor för stroke – skillnader i vård av patienter med TIA?2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 294.
    Norderyd, Ola
    et al.
    Institute for Postgraduate Dental Education, Region Jönköping County, Jönköping, Sweden; Faculty of Odontology, Malmö University, Malmö, Sweden.
    Koch, Göran
    Institute for Postgraduate Dental Education, Region Jönköping County, Jönköping, Sweden.
    Papias, Apostolos
    Institute for Postgraduate Dental Education, Region Jönköping County, Jönköping, Sweden.
    Kohler, Alkisti Anastassaki
    Institute for Postgraduate Dental Education, Region Jönköping County, Jönköping, Sweden.
    Helkimo, Anna Nydell
    Institute for Postgraduate Dental Education, Region Jönköping County, Jönköping, Sweden.
    Brahm, Carl-Otto
    Institute for Postgraduate Dental Education, Region Jönköping County, Jönköping, Sweden.
    Lindmark, Ulrika
    Centre for Oral Health, Department of Biomedicine and Natural Sciences, School of Health Sciences, Jönköping University, Jönköping, Sweden.
    Lindfors, Ninita
    Institute for Postgraduate Dental Education, Region Jönköping County, Jönköping, Sweden.
    Mattsson, Anna
    Public Dental Health Service, Region Jönköping County, Jönköping, Sweden.
    Rolander, Bo
    Futurum, Academy for Health and Care, Region Jönköping County, Jönköping, Sweden; Department of Behavioral Science and Social Work, School of Health Sciences, Jönköping University, Jönköping, Sweden.
    Ullbro, Christer
    Institute for Postgraduate Dental Education, Region Jönköping County, Jönköping, Sweden; UiT. The Arctic University of Norway, Tromsö, Norway.
    Gerdin, Elisabeth Wärnberg
    Örebro universitet, Institutionen för läkarutbildning. Dental Research Department, Public Dental Service, Region Örebro County, Örebro, Sweden.
    Frisk, Fredrik
    Institute for Postgraduate Dental Education, Region Jönköping County, Jönköping, Sweden.
    Oral health of individuals aged 3-80 years in Jonkoping, Sweden during 40 years (1973-2013)2015Ingår i: Swedish Dental Journal, ISSN 0347-9994, Vol. 39, nr 2, s. 69-86Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The aim of this epidemiological study performed in 2013 was to analyze various clinical and radiographic data on oral health and compare the results to those of four cross-sectional studies carried out 1973-2003. In 1973,1983,1993,2003, and 2013 random samples of 1,000;1,104;1,078; 987; and 1,010 individuals, respectively, were studied. The individuals were evenly distributed in the age groups 3,5,10,15, 20,30,40,50, 60,70, and 8o years. Eighty-year-olds were not included in 1973. All subjects were inhabitants of the city of Jonkoping, Sweden.

    The clinical and radiographic examination assessed edentulousness, removable dentures, implants, number of teeth, caries, restorations, oral hygiene, calculus, periodontal status, and endodontic treatment.

    The frequency of edentulous individuals aged 40-70 years was 16,12, 8,1, and 0.3% in 1973,1983,1993, 2003, and 2013, respectively. No complete denture wearer younger than 80-years old was found in 2013. During the 40-year period, the mean number of teeth in the age groups 30-80 years increased. In 2013, the 60-year-olds had nearly complete dentitions. Implants were found in all age groups from 30 years of age. The total number of individuals with implants was 36 in 2013.This was higher than earlier surveys,4 in 1993, and 18 in 2003.

    The percentage of children and adults without caries and restorations increased during the 40-year period. It was found that the percentage of caries-free 3- and 5-year-olds were 79% and 69%, respectively, of the individuals in 2013. In the age groups 10-20 years, the percentage of caries-free individuals increased between 2003 and 2013. In 2013,43% of the 15-year-olds were completely free from caries and restorations compared to 20% in 2003. In all age groups 5-60 years, DFS was lower in 2013 compared to the earlier examinations. There was no major change in DFS between 2003 and 2013 in the age groups 70 and 80 years. The most obvious change was the decrease in number of FS over the 40 year period of time. Regarding crowned teeth the most clear changes between 1973 to 2013 were the decrease in percentage of crowned teeth in the age goups 4o and 50-year-olds. The percentage of endodontically treated teeth decreased between 1973 and 2013 in all age groups.

    In age groups-Jo-30-year-olds a major reduction from about 3o% to 15% in mean plaque score was seen between 1973-2003. Only a minor change in plaque score was seen during the last decade. For the age groups 40 years and older, a decrease in the percentage of surfaces with plaque was observed between 2003-2o13.The percentage of tooth sites with gingivitis was for zo years and older about 4o% in 1973. In 2013, the percentage was about15%. The frequency of sites with gingivitis was generally lower in 2013 compared with the other years:1973-1993.

    The percentage of individuals with probing pocket depths >4mm increased with age. Between 2003-2013 a clear reduction was seen in all age groups in frequency of individuals with probing pocket depth >4mm. Over the 40-year period an increase in the number of individuals with no marginal bone loss and a decrease in the number of subjects with moderate alveolar bone loss were seen.

    The continuous improvement in oral health and the reduced need of restorative treatment will seriously affect the provision of dental helath care and dental delivery system in the near future.

  • 295.
    Nordmark, Jonatan
    Örebro universitet, Institutionen för läkarutbildning.
    Effects of Vitamin C on Pro-inflammatory Cytokine Induced Oxidative Stress and Tyrosine Uptake in Fibroblasts2014Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 296.
    Nordstedt, Sofia
    Örebro universitet, Institutionen för läkarutbildning.
    Can diet regimes be an option for treatment of acne vulgaris?: A systematic review of the literature2015Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
  • 297.
    Norén, Torbjörn
    et al.
    Örebro universitet, Institutionen för läkarutbildning. Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden.
    Johansson, Karin
    Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden.
    Unemo, Magnus
    Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden.
    Clostridium difficile PCR ribotype 046 is common among neonatal pigs and humans in Sweden2014Ingår i: Clinical Microbiology and Infection, ISSN 1198-743X, E-ISSN 1469-0691, Vol. 20, nr 1, s. O2-O6Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Clostridium difficile PCR ribotype 046 was found in 67% of neonatal piglets (45/67) sampled from three separate pig-breeding farms in Sweden. Sows from the same farms were tested and 50% were colonized in faeces and 30% were colonized on skin. An environmental source was suggested because identical PCR ribotypes were isolated from faeces as well as externally. Human C.difficile infection outbreaks in southern Sweden by the identical PCR ribotype 046 indicate its zoonotic potential.

  • 298.
    Nyberg, Jan
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Örebro University Hospital.
    Helenius, Gisela
    Örebro universitet, Institutionen för läkarutbildning. Örebro University Hospital.
    Dahlin, Christer
    Sahlgrenska Academy University of Gothenburg; NU-hospital organization, Trollhättan, Sweden.
    Johansson, Carina B.
    Sahlgrenska Academy University of Gothenburg.
    Omar, Omar
    Sahlgrenska Academy University of Gothenburg.
    Effect of radiotherapy on osseointegration: in vivo gene expression and implant stability after single high-dose irradiationManuskript (preprint) (Övrigt vetenskapligt)
  • 299. Nygren, J
    et al.
    Thacker, J
    Carli, F
    Fearon, K C H
    Norderval, S
    Lobo, D N
    Ljungqvist, Olle
    Örebro universitet, Institutionen för läkarutbildning.
    Soop, M
    Ramirez, J
    Guidelines for perioperative care in elective rectal/pelvic surgery: enhanced recovery after surgery (ERAS®) Society recommendations2012Ingår i: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 31, nr 6, s. 801-816Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: This review aims to present a consensus for optimal perioperative care in rectal/pelvic surgery, and to provide graded recommendations for items for an evidenced-based enhanced recovery protocol.

    METHODS: Studies were selected with particular attention paid to meta-analyses, randomized controlled trials and large prospective cohorts. For each item of the perioperative treatment pathway, available English-language literature was examined, reviewed and graded. A consensus recommendation was reached after critical appraisal of the literature by the group.

    RESULTS: For most of the protocol items, recommendations are based on good-quality trials or meta-analyses of good-quality trials (evidence grade: high or moderate).

    CONCLUSIONS: Based on the evidence available for each item of the multimodal perioperative care pathway, the Enhanced Recovery After Surgery (ERAS) Society, European Society for Clinical Nutrition and Metabolism (ESPEN) and International Association for Surgical Metabolism and Nutrition (IASMEN) present a comprehensive evidence-based consensus review of perioperative care for rectal surgery.

  • 300. Nygren, J
    et al.
    Thacker, J
    Carli, F
    Fearon, KC
    Norderval, S
    Lobo, DN
    Ljungqvist, Olle
    Örebro universitet, Institutionen för läkarutbildning.
    Soop, M
    Ramirez, J
    Guidelines for perioperative care in elective rectal/pelvic surgery: enhanced recovery after surgery (ERAS(®)) society recommendations2013Ingår i: World Journal of Surgery, ISSN 0364-2313, E-ISSN 1432-2323, Vol. 37, nr 2, s. 285-305Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: This review aims to present a consensus for optimal perioperative care in rectal/pelvic surgery, and to provide graded recommendations for items for an evidenced-based enhanced recovery protocol.

    METHODS: Studies were selected with particular attention paid to meta-analyses, randomized controlled trials and large prospective cohorts. For each item of the perioperative treatment pathway, available English-language literature was examined, reviewed and graded. A consensus recommendation was reached after critical appraisal of the literature by the group.

    RESULTS: For most of the protocol items, recommendations are based on good-quality trials or meta-analyses of good-quality trials (evidence grade: high or moderate).

    CONCLUSIONS: Based on the evidence available for each item of the multimodal perioperative care pathway, the Enhanced Recovery After Surgery (ERAS) Society, European Society for Clinical Nutrition and Metabolism (ESPEN) and International Association for Surgical Metabolism and Nutrition (IASMEN) present a comprehensive evidence-based consensus review of perioperative care for rectal surgery.

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