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  • 42501.
    van Ooijen, Erik
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Making mythopoeic meaning out of plants2019Inngår i: Cogent Arts and Humanities, E-ISSN 2331-1983, Vol. 6, nr 1, artikkel-id 1687256Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The article discusses literary and scientific discourse in relation to plant cognition. I argue that one purpose of literature is to let humans make meaning out of their environment. My focus is not on literature as fiction, or any a priori faculty of counterfactual construction. Rather, I consider literature as the inspired response to external phenomena. In this aspect, literature springs from outside; and this it shares with scientific explanation. But where science lays bare the mechanical laws of the universe, literature operates with compelling narratives of individual wills. I further suggest that the literary mode is specifically suited for envisioning non-human life. Poetic thought is considered as a mode of human cognition that, by suspending the distance between human and world, allows us to think modes of non-human cognition. In literature, we are able to represent those affects we share with other forms of biological life. My focus is on two literary representations of plant life and the blending of life forms in stories where people turn into plants. I start by considering how a few botanists have taken the literary mode as a negative point of departure for their attempts to explain plant behavior. Then, I muster two theoretical accounts in order to read two such stories. Henri and Henriette Frankfort’s description of mythopoeic thought is used as the starting point for an interpretation of Ovid’s take on the myth of Echo and Narcissus; and Roger Caillois’ “comparative biology” for a reading of Johan Borgen’s short story “Kaprifolium”.

  • 42502.
    van Ooijen, Erik
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    On the Brink of Virtual Extinction: Hunting and Killing Animals in Open World Video Games2018Inngår i: Eludamos - Journal for Computer Game Culture, ISSN 1866-6124, E-ISSN 1866-6124, Vol. 9, nr 1, s. 33-45Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The article focuses on the underlying structures evaluating acts of violence against different bodies in games. Taking the hunting mechanics of open-world games as its point of discussion, it looks at how game design manifests procedural arguments on the ideological aspects of animal violence.

    Whereas there are instances of explicit violence in these games, the article argues that the explicitness of such depictions serves to emphasize the “messiness” of producing animal goods, thus impeding the “carnist” ideological view of meat as pure commodity. By considering how games distinguish humans from animals, it looks at what violent acts are rendered acceptable or unacceptable, and notes distinctions between what bodies are protected by, or exempt from, moral and legal rights.

    Finally, the article considers how the algorithmic nature of spawning makes digital animals immune to extinction. Interestingly enough, the article nevertheless notices how a game may intentionally diverge from this logic in order to defamiliarize its established logic.

    Among the games discussed are Rockstar’s Red Dead Redemption (2010), and Ubisoft’s Assassin’s Creed III (2012) and Far Cry 3 (2012).

  • 42503.
    van Ooijen, Erik
    Örebro universitet, Humanistiska institutionen.
    Ordet och köttet: om teorin kring litterära karaktärer [red. Lars-Åke Skalin) och Berättaren: en gäckande röst i texten [red. Lars-Åke Skalin]2004Inngår i: Tidskrift för litteraturvetenskap, ISSN 1104-0556, E-ISSN 2001-094X, Vol. 33, nr 3-4, s. 218-223Artikkel, omtale (Annet vitenskapelig)
  • 42504.
    van Ooijen, Erik
    Örebro universitet, Akademin för humaniora, utbildning och samhällsvetenskap.
    Projects and projections: on focus and perspective in drama2009Inngår i: Borderliners: searching the boundaries of narrativity and narratology / [ed] Per Krogh Hansen, Copenhagen: Medusa , 2009, s. 219-237Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [en]

    The article examines the concept of focus and perspective in drama, a genre traditionally uncared for by narrative theory. The topic is treated in a twofold manner. The first part of the paper discusses examples from classical, fin de siècle and modernist dramatic texts using subjectivity on the discursive level, as representational projections of figural perception and consciousness. The second part treats subjectivity on the structural level of narrative projects. By revising the Greimasian actantial model the author tries to define dramatic narrative in terms of power, as the dialectic between hierarchical relations of centrality and marginality, something which becomes manifest in the genre’s conventional list of dramatis personae.

  • 42505.
    van Ooijen, Erik
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Recension av: Torsten Pettersson (red.), Jag gör med dig vad jag vill: Perspektiv på våld och våldsskildringar, Göteborg: Makadam, 20192019Inngår i: Tidskrift för litteraturvetenskap, ISSN 1104-0556, E-ISSN 2001-094X, Vol. 49, nr 4, s. 113-117Artikkel, omtale (Annet vitenskapelig)
  • 42506.
    van Ooijen, Erik
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Sjöpungsmissbruket2018Inngår i: Aiolos, ISSN 1400-7770, Vol. 62, s. 109-119Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [sv]

    Om August Strindbergs idé att växter evolutionärt utvecklats ur djuren, med fokus på sjöpungens idéhistoria från antik tid till idag.

  • 42507.
    van Ooijen, Erik
    Örebro universitet, Humanistiska institutionen.
    The affluence of literature2008Inngår i: Narrativity, fictionality, and literariness: the narrative turn and the study of literary fiction / [ed] Lars-Åke Skalin, Örebro: Örebro university , 2008, s. 113-129Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 42508.
    van Ooijen, Erik
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    The Dark Turn2019Inngår i: Perspectives on Ecocriticism: Local Beginnings, Global Echoes / [ed] Ingemar Haag, Karin Molander Danielsson, Marie Öhman, Thorsten Päplow, Newcastle upon Tyne: Cambridge Scholars Publishing, 2019, s. 101-112Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    Explores the "dark turn" in contemporary eco-theory through the shades of dark green, dark, and black ecology.

  • 42509.
    van Ooijen, Erik
    Örebro universitet, Akademin för humaniora, utbildning och samhällsvetenskap.
    The mold of writing: style and structure in Strindberg's chamber plays2010Doktoravhandling, monografi (Annet vitenskapelig)
    Abstract [en]

    The thesis examines the five plays published by August Strindberg under the label of Chamber Plays: Stormy Weather, The Burned Lot, The Ghost Sonata, The Pelican (all 1907), and The Black Glove (1909). It takes its point of departure in a particular aspect of Strindberg’s way of writing as he actually describes it himself: during the act of deliberate composing, a productive fever tends to emerge bringing an element of chance to the work. The thesis defines the effect produced by this “fever” as the tension generated between, on the one hand, structure or form, and, on the other hand, style or writing. These concepts are associated with a tradition, primarily in French literary theory, which pays attention to what is described as a friction between the general linguistic aspect of literature (genres, recurring and recognizable patterns) and the individual aspect (the peculiar and idiosyncratic style of an author embodied in his material habitus). Thus the ambiguity found in the thesis’ title: the “mold” alludes partly to the stereotypes or matrices of language, partly to the “fungi” that, according to Strindberg, could be considered an adequate image for writing; the poetic work, says Strindberg, grows like mold from the author’s brain.

    Theoretical questions, primarily of a formal and interpretational nature, are continuously discussed since one of the main points is that the Strindbergian way of writing restricts what kind of interpretation may be given his works. The eventual contrast between form and interpretation is, furthermore, related to a general theme developed throughout the Chamber Plays concerning the meaning of life.

    It is stressed that the five plays show distinct formal and thematic differences; thus, a separate chapter is dedicated to each of them. The chapter on Stormy Weather examines the structural use of focus and the hierarchy of character-functions related to the centering on a protagonist. The Burned Lot is discussed from the concept of a ruin to describe how a multitude of conflicting forms come together to produce a fragmentary result. The Ghost Sonata is described in terms of simulation: while Strindberg alludes to certain dramatic patterns, he also distorts them whereby new effects are created. The chapter on The Pelican explores the temporal flow of the play and how it relates to writing. The thesis ends with a discussion of The Black Glove and its relation to the preceding Chamber Plays and also to the Strindbergian oeuvre. The concept of weed is used to distinguish a recurring element in Strindberg’s work as well as in his worldview.

    Throughout the thesis, the discussion is consistently related to previous studies and commentaries on the plays.

  • 42510.
    van Ooijen, Erik
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Tre kroppsöppningar i den erotiska begärsekonomin2018Inngår i: Tydningen, ISSN 2001-4570, nr 27-28, s. 64-72Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • 42511.
    van Ooijen, Erik
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Växternas förstånd2018Inngår i: Strindbergiana, ISSN 0282-8006, Vol. 33, s. 85-99Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [sv]

    Om Strindberg som föregångare till modern växtfilosofi

  • 42512.
    van Ooijen, Erik
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Växtsjälen2018Collection/Antologi (Annet vitenskapelig)
    Abstract [sv]

    Temanummer ägnat åt den filosofiska idén om "växtsjälen", från antik tid till modern växtneurobiologi.

  • 42513.
    Van Poeck, Katrien
    et al.
    Ghent University, Ghent, Belgium.
    Östman, Leif
    Uppsala University, Uppsala, Sweden.
    Öhman, Johan
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Ethical moves: How teachers can open-up a space for articulating moral reactions and deliberating on ethical opinions regarding sustainability issues2019Inngår i: Sustainable Development Teaching: Ethical and Political Challenges / [ed] Katrien Van Poeck, Leif Östman and Johan Öhman, Milton Park and New York: Routledge, 2019, s. 153-161Kapittel i bok, del av antologi (Fagfellevurdert)
    Abstract [en]

    This chapter focuses on teachers’ influence on students’ ethical and moral learning and, in particular, on how teachers can promote students’ growth as moral subjects in environmental and sustainability education (ESE) practice. It describes and discusses a variety of ‘ethical moves’, i.e. actions performed by a teacher that open up a space for articulating moral reactions and deliberating on ethical opinions. Six types of ethical moves are distinguished: clarifying ethical moves, articulating ethical moves, evaluating ethical moves, testing ethical moves, controversy-creating ethical moves and hierarchizing ethical moves. By performing such moves, the authors argue and illustrate, teachers can turn students’ moral experiences into fruitful drivers for pluralistic ESE by enabling students to express and share moral experiences and standpoints, to articulate ethical differences and controversies and to reflect and deliberate on moral reactions and dilemmas.

  • 42514.
    Van Poeck, Katrien
    et al.
    Ghent University’s Centre for Sustainable Development, Ghent, Belgium.
    Östman, Leif
    Uppsala University, Department of Education, Uppsala, Sweden.
    Öhman, Johan
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Introduction: sustainable development teaching – ethical and political challenges2019Inngår i: Sustainable development teaching: ethical and political challenges / [ed] Katrien Van Poeck, Leif Östman och Johan Öhman, Routledge, 2019, s. 1-12Kapittel i bok, del av antologi (Fagfellevurdert)
  • 42515.
    Van Poeck, Katrien
    et al.
    Ghent University, Ghent, Belgium.
    Östman, LeifUppsala University, Uppsala, Sweden.Öhman, JohanÖrebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Sustainable Development Teaching: Ethical and Political Challenges2019Collection/Antologi (Fagfellevurdert)
    Abstract [en]

    The aim of this book is to support and inspire teachers to contribute to much-needed processes of sustainable development and to develop teaching practices and professional identities that allow them to cope with the specificity of sustainability issues and, in particular, with the teaching challenges related to the ethical and political dimension of environmental and sustainability education.

    Bringing together recent scholarship on the topic, this book translates state-of-the-art academic research into teaching models, methods and tools. Starting with an outline of the challenge of sustainability, it offers insights and models for understanding the interesting yet ambiguous concept of ‘sustainable development’ and the complex process of transforming society in a more sustainable direction (Part I). It then goes on to provide a guide to preparing courses and lessons as well as tools for reflection about teaching practices and the multiplicity of approaches to addressing ethical and political challenges in sustainable development teaching (Part II). Finally, the book offers useful conceptual frameworks, models and typologies about the concrete design and implementation of sustainable development teaching (Part III).

    This book will be essential reading for students of education, as well as teachers in compulsory and higher education and sustainability education researchers.

  • 42516. Van Poppel, H.
    et al.
    Nilsson, S.
    Algaba, F.
    Bergerheim, U.
    Department of Urology, University Hospital K.U. Leuven, Belgium.
    Dal Cin, P.
    Fleming, S.
    Hellsten, S.
    Kirkali, Z.
    Klotz, L.
    Lindblad, Per
    Ljungberg, B.
    Mulders, P.
    Roskams, T.
    Ross, R. K.
    Walker, C.
    Wersall, P.
    Precancerous lesions in the kidney2000Inngår i: Scandinavian Journal of Urology and Nephrology, Supplementum, ISSN 0300-8886, E-ISSN 1651-2537, nr 205, s. 136-165Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Renal cell carcinoma (RCC), although occurring less frequently than prostate and bladder cancer, is actually the most malignant urologic disease, killing >35% of affected patients. Therefore, investigation of the nature of premalignant lesions of the kidney is a relevant issue. Following the most recent histological classification RCC can be subdivided into four categories: conventional RCC; papillary RCC; chromophobe RCC; and collecting duct carcinoma. In contrast to many genitourinary malignancies, premalignant alterations in the kidney are scarcely described. Intratubular epithelial dysplasia has been recognized as the most common precursor of RCC. In analogy to prostatic intraepithelial neoplasia (PIN), the premalignant lesions of the kidney are described as high or low-grade renal intratubular neoplasia. In contrast, precancerous lesions have been described as part of the von Hippel-Lindau syndrome (VHL) where the evolution from a simple cyst to an atypical cyst with epithelial hyperplasia to cystic or solid conventional-type RCC is well documented. Finally, in the genesis of papillary RCC an adenoma-carcinoma sequence has been recognized with specific genetic changes. There are no data on the epidemiology of premalignant lesions of the kidney, but research into the etiology of RCC has been extended substantially. Familial and genetic factors are well documented in VHL disease, in hereditary papillary RCC, in the tuberous sclerosis complex and in familial RCC. Cigarette smoking and obesity are established risk factors for RCC. Hypertension or its medication has also been associated with an increased risk. Among dietary factors an inverse relation between risk and consumption of vegetables and fruit has been found. Occupational exposure to substances such as asbestos and solvents has been linked to an increased risk of RCC. Specific RCC variants have distinctive chromosome alterations and several genes have been implicated in the development of RCC. Loss of material from the 3p chromosome characterizes conventional RCC and the deletion of the VHL suppressor gene plays an important role in the genesis of this RCC variant. In contrast, numerical changes with trisomy of chromosomes 7 and 17 and loss of the sex chromosome are typical changes in papillary tumors, whereas papillary RCC have additional trisomies. Chromophobe RCC is characterized by loss of chromosomes with a combination of monosomies. Less consistent genetic alterations are associated with collecting duct carcinoma. The traditional treatment of RCC is surgery by radical or partial nephrectomy. The latter approach carries a risk of tumor recurrence as a result of unrecognized satellite lesions or premalignant lesions that might have been present at the time of surgery. However, the reported recurrence rates after partial nephrectomy are <1% and therefore the possible presence of premalignant disease does not alter the actual treatment strategy advocated. Although multifocality and bilateral occurrence of RCC are much more likely in cases of papillary RCC, biopsy of the renal remnant or contralateral kidney is not justified even in patients with this tumor type. Conversely, patients with RIN in a partial or radical nephrectomy specimen or in a renal biopsy taken for whatever reason should be subjected to closer follow-up with regularly repeated ultrasound. When an effective chemopreventive regimen becomes available it might be useful for patients with an inherited risk of RCC as well as in those who are at risk of tumor recurrence after intervention. Mass screening with the purpose of detecting RCC at its earliest stage is not recommended at the present time, but screening focused on certain risk groups can be advocated. Further research is needed to identify avoidable risks, develop effective chemoprevention and recognize patients at risk.

  • 42517.
    Van Remoortel, Marianne
    et al.
    Ghent University, Ghent, Belgium.
    Ewins, Kristin
    Örebro universitet.
    Koffeman, Maaike
    Radboud University, Nijmegen, The Netherlands.
    Philpotts, Matthew
    University of Manchester, Manchester, UK.
    Joining Forces: European Periodical Studies as a New Research Field2016Inngår i: Journal of European Periodical Studies, ISSN 1684-0186, E-ISSN 1541-4329, Vol. 1, nr 1, s. 1-3Artikkel i tidsskrift (Annet vitenskapelig)
  • 42518. van Steenberghe, Daniel
    et al.
    Johansson, Carina B.
    Örebro universitet, Hälsovetenskapliga institutionen. Örebro universitet, Institutionen för klinisk medicin.
    Quirynen, Marc
    Molly, Liene
    Albrektsson, Tomas
    Naert, Ignace
    Bone augmentation by means of a stiff occlusive titanium barrier: a study in rabbits and humans2003Inngår i: Clinical Oral Implants Research, ISSN 0905-7161, E-ISSN 1600-0501, Vol. 14, nr 1, s. 63-71Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    It has already been shown that occlusive titanium barriers have osteoconductive properties. These barriers, however, cover only a limited surface area and have only been used in animal experiments. The aim of this study was to evaluate bone neogenesis under a pre-shaped titanium barrier placed over the top of the rabbit skull and the top of highly resorbed edentulous upper-jaw bone in patients. Computed tomography (CT) scans made it possible to pre-shape the titanium barrier according to individual bone shape in human experiments. On the rabbit skull, tissue augmentation of up to 6 mm 1 year after barrier placement was observed, while the original thickness of skull bone was on average between 1.5 and 2.5 mm. The bone, which remained histologically immature for 1 year, grew systematically along the titanium surface, illustrating its osteoconductivity. Even after removal of the barrier, on average, 75.3 and 59.4% of the newly created tissue volume was maintained after 3 and 9 months, respectively. Clinical observations on 10 consecutive patients showed that, in those (5/10) in which the barrier remained unexposed for several months, an increase of the jawbone height and width of up to 16 mm could be observed when the barrier was removed after 12-18 months. As in the rabbits at barrier removal, the bone demonstrated a limited degree of mineralization as ascertained from biopsies. This newly formed osteoid tissue allowed the insertion of 33 screw-shaped titanium implants which in most cases (30/33) successfully osseointegrated to support a fixed prosthesis. The surrounding marginal bone level remained stable even up to 5 years after implant placement. Both animal and clinical data demonstrate that guided bone neogenesis under a subperiosteally placed titanium barrier can reach large volumes.

  • 42519.
    Van Tiggelen, H.
    et al.
    Skin Integrity Research Group (SKINT), University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.
    LeBlanc, K.
    School of Physical Therapy, Faculty of Health Sciences, Western University, London, Ontario, Canada; Wound Ostomy Continence Institute/ Association of Nurses Specialized in Wound Ostomy Continence, Canada.
    Campbell, K.
    School of Physical Therapy, Faculty of Health Sciences, Western University, London, Ontario, Canada.
    Woo, K.
    School of Nursing, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada.
    Baranoski, S.
    Nursing Advisory Board, Rasmussen College, Romeoville/Joliet, Illinois, USA.
    Chang, Y. Y.
    Division of Nursing, Speciality Nursing (Wound Care), Singapore General Hospital, Bukit Merah, Singapore.
    Dunk, A. M.
    Tissue Viability Unit, Canberra Hospital, Canberra Health Services, Canberra, Australia; School of Nursing, Faculty of Health, University of Canberra, Canberra, Australia.
    Gloeckner, M.
    UnityPoint Health Trinity, Rock Island, Illinois & Bettendorf, Iowa, USA.
    Hevia, H.
    Nursing School, Nursing Department, Andrés Bello University, Viña del Mar, Chile.
    Holloway, S.
    Centre for Medical Education, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Wales, UK.
    Idensohn, P.
    CliniCare Medical Centre, KwaZulu-Natal, Ballito, South Africa; School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Wales, UK; School of Nursing, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
    Karadağ, A.
    School of Nursing, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
    Koren, E.
    Leumit HMO, Vascular Ulcer Clinic, Geula, Jerusalem, Israel; Israeli Wound Care Management and Research Association (IWCMRA), Israel.
    Kottner, J.
    Skin Integrity Research Group (SKINT), University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium; Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Langemo, D.
    College of Nursing, University of North Dakota, Grand Forks, North Dakota, USA; Langemo and Associates, Grand Forks, North Dakota, USA.
    Ousey, K.
    Institute of Skin Integrity and Infection Prevention, Department of Nursing and Midwifery, University of Huddersfield, UK; School of Nursing, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia; School of Nursing & Midwifery, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.
    Pokorná, A.
    Department of Nursing, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
    Romanelli, M.
    Department of Dermatology, University of Pisa, Pisa, Italy.
    Santos, V. L. C. G.
    School of Nursing, Medical-Surgical Nursing Department, University of São Paulo, São Paulo, Brazil; of Nursing, Portuguese Catholic University, Porto, Portugal.
    Smet, S.
    Wound Care Center, Ghent University Hospital, Ghent, Belgium.
    Tariq, G.
    Wound Care Unit, Sheikh Khalifa Medical City (SKMC), Abu Dhabi, United Arab Emirates.
    Van den Bussche, K.
    Skin Integrity Research Group (SKINT), University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.
    Van Hecke, A.
    University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium; Nursing Department, Ghent University Hospital, Ghent, Belgium.
    Verhaeghe, S.
    University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium; Department Health Care, VIVES University College, Roeselare, Belgium.
    Vuagnat, H.
    Centre for Wounds and Wound Healing, University Hospitals of Geneva, Geneva, Switzerland.
    Williams, A.
    Wound and Ostomy Care, Reston Hospital Center, Reston, VA, USA.
    Beeckman, Dimitri
    Örebro universitet, Institutionen för hälsovetenskaper. Skin Integrity Research Group (SKINT), University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium; School of Nursing & Midwifery, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Research Unit of Plastic Surgery, Department of Clinical Research, Faculty of Health Sciences, Southern Denmark; School of Nursing and Midwifery, Monash University, Australia.
    Standardising the classification of skin tears: validity and reliability testing of the International Skin Tear Advisory Panel (ISTAP) Classification System in 44 countries2019Inngår i: British Journal of Dermatology, ISSN 0007-0963, E-ISSN 1365-2133Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Skin tears are acute wounds that are frequently misdiagnosed and underreported. A standardised and globally adopted skin tear classification system with supporting evidence for diagnostic validity and reliability is required to allow assessment and reporting in a consistent way.

    OBJECTIVES: To measure the validity and reliability of the International Skin Tear Advisory Panel (ISTAP) Classification System internationally.

    METHODS: A multi-country study was set up to validate the content of the ISTAP Classification System through expert consultation in a two-round Delphi procedure involving 17 experts from 11 countries. An online survey including 24 skin tear photographs was conducted in a convenience sample of 1601 healthcare professionals from 44 countries to measure diagnostic accuracy, agreement, inter-rater reliability, and intra-rater reliability of the instrument.

    RESULTS: A definition for the concept of a "skin flap" in the area of skin tears was developed and added to the initial ISTAP Classification System consisting of three skin tear types. The overall agreement with the reference standard was 0.79 (95% CI 0.79-0.80) and sensitivity ranged from 0.74 (95% CI 0.73-0.75) to 0.88 (95% CI 0.87-0.88). The inter-rater reliability was 0.57 (95% CI 0.57-0.57). The Cohen's Kappa measuring intra-rater reliability was 0.74 (95% CI 0.73-0.75).

    CONCLUSIONS: The ISTAP Classification System is supported by evidence for validity and reliability. The ISTAP Classification System should be used for a systematic assessment and reporting of skin tears in clinical practice and research globally.

  • 42520.
    Van Tiggelen, Hanne
    et al.
    Skin Integrity Research Group (SKINT), University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.
    Van Damme, Nele
    Skin Integrity Research Group (SKINT), University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.
    Theys, Sofie
    Skin Integrity Research Group (SKINT), University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.
    Vanheyste, Eline
    Skin Integrity Research Group (SKINT), University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.
    Verhaeghe, Sofie
    University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium; Department Health Care, VIVES University College, Roeselare, Belgium.
    LeBlanc, Kimberly
    School of Nursing, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada; KDS Professional Consulting, Ottawa, Ontario, Canada.
    Campbell, Karen
    School of Physical Therapy, Faculty of Health Sciences, Western University, London, Ontario, Canada.
    Woo, Kevin
    School of Nursing, Faculty of Health Sciences, Queen's University, Kingston, Ontario.
    Van Hecke, Ann
    University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium; Nursing Department, Ghent University Hospital, Ghent, Belgium.
    Beeckman, Dimitri
    Örebro universitet, Institutionen för hälsovetenskaper. Skin Integrity Research Group (SKINT), University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium; School of Nursing & Midwifery, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.
    The prevalence and associated factors of skin tears in Belgian nursing homes: A cross-sectional observational study2019Inngår i: Journal of tissue viability, ISSN 0965-206X, Vol. 28, nr 2, s. 100-106Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Although skin tears are among the most prevalent acute wounds in nursing homes, their recognition as a unique condition remains in its infancy. Elderly patients are at risk of developing skin tears due to increased skin fragility and other contributing risk factors. In order to provide (cost-) effective prevention, patients at risk should be identified in a timely manner.

    OBJECTIVES: (1) To determine the point prevalence of skin tears and (2) to identify factors independently associated with skin tear presence in nursing home residents.

    METHODS: A cross-sectional observational study was set up, including 1153 residents in 10 Belgian nursing homes. Data were collected by trained researchers and study nurses using patient records and skin observations. A multiple binary logistic regression model was designed to explore independent associated factors (significance level α < 0.05).

    RESULTS: The final sample consisted of 795 nursing home residents, of which 24 presented with skin tears, resulting in a point prevalence of 3.0%. Most skin tears were classified as category 3 (defined as complete flap loss) according to the International Skin Tear Advisory Panel (ISTAP) Classification System and 75.0% were located on the lower arms/legs. Five independent associated factors were identified: age, history of skin tears, chronic use of corticosteroids, dependency for transfers, and use of adhesives/dressings.

    CONCLUSIONS: This study revealed a skin tear prevalence of 3.0% in nursing home residents. Age, history of skin tears, chronic use of corticosteroids, dependency for transfers, and use of adhesives/dressings were independently associated with skin tear presence.

  • 42521.
    van Vollenhoven, Ronald F.
    et al.
    Departments of Rheumatology, Karolinska Hospital, Stockholm, Sweden.
    Gunnarsson, Iva
    Departments of Rheumatology, Karolinska Hospital, Stockholm, Sweden.
    Welin Henriksson, Elisabet
    Departments of Rheumatology, Karolinska Hospital, Stockholm, Sweden.
    Sundelin, Birgitta
    Departments of Pathology, Karolinska Hospital, Stockholm, Sweden.
    Österborg, Anders
    Departments of Haematology, Karolinska Hospital, Stockholm, Sweden.
    Jacobson, Stefan H.
    Departments of Nephrology, Karolinska Hospital, Stockholm, Sweden.
    Klareskog, Lars
    Departments of Rheumatology, Karolinska Hospital, Stockholm, Sweden.
    Biopsy-verified response of severe lupus nephritis to treatment with rituximab (anti-CD20 monoclonal antibody) plus cyclophosphamide after biopsy-documented failure to respond to cyclophosphamide alone2004Inngår i: Scandinavian Journal of Rheumatology, ISSN 0300-9742, E-ISSN 1502-7732, Vol. 33, nr 6, s. 423-427Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: The monoclonal anti-B cell antibody rituximab (Rituxin, Mabthera) may be of benefit in antibody-driven diseases, including systemic lupus erythematosus (SLE) nephritis.

    PATIENTS AND TREATMENT: Two female patients with biopsy-confirmed severe and active SLE nephritis despite treatment with cyclophosphamide (CyX) were given four rituximab infusions plus two additional CyX infusions.

    RESULTS: Both patients tolerated the treatment well and SLE activity improved. On repeat kidney biopsy after the combined treatment, Patient 1 showed a profound reduction of nephritis activity, and she was maintained on low-dose prednisolone only. A repeat biopsy after 1 year confirmed the sustained reduction of lupus nephritis activity. In Patient 2, rebiopsy after combined treatment also showed a significant reduction in disease activity.

    CONCLUSION: These cases provide histopathological documentation of a significant treatment benefit from rituximab plus CyX in two patients refractory to CyX alone. This combination is being explored further as salvage therapy for such CyX-resistant patients.

  • 42522. van Vught, A. J. A. H.
    et al.
    Nieuwenhuizen, A. G.
    Veldhorst, M. A. B.
    Brummer, Robert
    Örebro universitet, Hälsoakademin.
    Westerterp-Plantenga, M. S.
    The effects of dietary protein on the somatotropic axis: a comparison of soy, gelatin, alpha-lactalbumin and milk2010Inngår i: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 64, nr 5, s. 441-446Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND/OBJECTIVES: Growth hormone (GH) is an important regulator of growth and body composition. It has been shown that GH release can be promoted by administration of various amino acids (AAs), such as arginine and lysine, that are present in soy protein. We previously showed that oral ingestion of soy protein stimulates the GH release, it is not known however to which extent other proteins stimulate the GH secretion.

    SUBJECTS/METHODS: Ingestion of soy protein (soy), gelatin protein (gelatin), alpha-lactalbumin protein (alpha-lactalbumin) and milk protein (milk) were compared on their GH-stimulating capacity. After oral ingestion of protein (0.6 g protein per kg bodyweight), blood was sampled every 20 min for 5 h to analyze GH, AA, insulin and glucose concentrations. The study was performed in eight healthy women (aged 19-26 years; body mass index 19-26 kg/m(2)) in a randomized, single blind, placebo-controlled crossover design.

    RESULTS: GH responses were more increased after ingestion of gelatine (8.2+/-1.1 microg/l) compared with ingestion of soy, alpha-lactalbumin and milk (5.0+/-0.8, 4.5+/-0.6 and 6.4+/-1.0 microg/l, respectively) (P<0.05). After ingestion of each protein, GH responses were higher compared with placebo ingestion (P<0.05). Simultaneously ingestion of gelatin resulted in the highest serum-arginine concentrations (ARG) compared with after ingestion of the other proteins (P<0.05). Insulin as well as glucose concentrations were not different after ingestion of the various proteins (P<0.05).

    CONCLUSIONS: The GH-promoting activity of protein depends on the protein source, in that, gelatin protein is the most potent GH stimulator. Arginine may be the responsible AA in the GH-promoting effect of gelatin, although each protein may have its own specific AA-spectrum involved in the stimulation of the somatotropic axis.

  • 42523.
    van Vught, A. J. A. H.
    et al.
    Dept Human Biol, Fac Hlth Med & Life Sci, Med Ctr, Maastricht Univ, Maastricht, Netherlands; TI Food & Nutr, Wageningen, Netherlands.
    Nieuwenhuizen, A. G.
    Dept Human Biol, Fac Hlth Med & Life Sci, Med Ctr, Maastricht Univ, Maastricht, Netherlands; TI Food & Nutr, Wageningen, Netherlands.
    Veldhorst, M. A. B.
    Dept Human Biol, Fac Hlth Med & Life Sci, Med Ctr, Maastricht Univ, Maastricht, Netherlands; TI Food & Nutr, Wageningen, Netherlands.
    Brummer, Robert
    Örebro universitet, Hälsoakademin. TI Food & Nutr, Wageningen, Netherlands.
    Westerterp-Plantenga, M. S.
    Dept Human Biol, Fac Hlth Med & Life Sci, Med Ctr, Maastricht Univ, Maastricht, Netherlands; TI Food & Nutr, Wageningen, Netherlands.
    The effects of protein ingestion on GH concentrations in visceral obesity2010Inngår i: Hormone and Metabolic Research, ISSN 0018-5043, E-ISSN 1439-4286, Vol. 42, nr 10, s. 740-745Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Growth hormone (GH), a hormone originating from the anterior pituitary gland, is an important regulator of metabolism and body composition. Low GH secretion is associated with features of the metabolic syndrome, in particular increased visceral body fat and decreased lean body mass. It has been shown that GH release can be promoted by ingestion of protein, in particular gelatin protein. The question remains; is the GH-promoting effect of gelatin protein also present in a population with blunted GH response, such as visceral obesity? 8 lean women (age: 23 +/- 3 years, BMI: 21.6 +/- 2.0 kg/m(2)) and 8 visceral obese women (age: 28 +/- 7 years, BMI: 33.8 +/- 5.5 kg/m(2)) were compared with regard to their 5-h GH response after oral ingestion of gelatin protein (0.6 g protein per kg bodyweight), placebo (water), or injection of growth hormone releasing hormone (GHRH) (1 mu/kg body weight), in a randomized crossover design. GH response after placebo, gelatin protein, or GHRH was higher in lean subjects than in visceral obese subjects (p < 0.05). Ingestion of gelatin protein increased GH response compared with placebo in both visceral obese (182.1 +/- 81.6 mu g/l.5h vs. 28.4 +/- 29.8 mu g/l.5h) and lean (631.7 +/- 144.2 mu g/l.5h vs. 241.0 +/- 196.8 mu g/l.5h) subjects (p < 0.05). GH response after ingestion of gelatin protein in visceral obese did not differ from that in lean, placebo-treated subjects (p = 0.45). GH concentrations after GHRH injection correlated significantly with GH concentrations after gelatin ingestion (AUC; r = 0.71, p < 0.01, Peak; r = 0.81, p < 0.01). Further research is needed to investigate if gelatin protein is able to improve metabolic abnormalities in hyposomatotropism in the long term or to investigate the relevance of protein as diagnostic tool in hyposomatotropism.

  • 42524.
    van Vught, Anneke J. A. H.
    et al.
    Dept Human Biol, Univ Limburg, Maastricht, Netherlands; TI Food & Nutr, Wageningen, Netherlands.
    Heitmann, Berit L.
    Res Unit Dietary Studies, Inst Prevent Med, Univ Copenhagen Hosp, Copenhagen, Denmark.
    Nieuwenhuizen, Arie G.
    Dept Human Biol, Univ Limburg, Maastricht, Netherlands; TI Food & Nutr, Wageningen, Netherlands.
    Veldhorst, Margriet A. B.
    Dept Human Biol, Univ Limburg, Maastricht, Netherlands; TI Food & Nutr, Wageningen, Netherlands.
    Andersen, Lars Bo
    Inst Sport Sci & Clin Biomech, Univ So Denmark, Odense, Denmark.
    Hasselstrom, Henriette
    Inst Sport Sci & Clin Biomech, Univ So Denmark, Odense, Denmark.
    Brummer, Robert
    Örebro universitet, Hälsoakademin.
    Westerterp-Plantenga, Margriet S.
    Dept Human Biol, Univ Limburg, Maastricht, Netherlands; TI Food & Nutr, Wageningen, Netherlands.
    Association between intake of dietary protein and 3-year-change in body growth among normal and overweight 6-year-old boys and girls (CoSCIS)2010Inngår i: Public Health Nutrition, ISSN 1368-9800, E-ISSN 1475-2727, Vol. 13, nr 5, s. 647-653Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: Growth hormone (GH) affects linear growth and body composition, by increasing the secretion of insulin-like growth factor-I (IGF-I), muscle protein synthesis and lipolysis. The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion. The present paper aimed to investigate associations between PROT intake as well as intake of the specific amino acids ARG and LYS, and subsequent 3-year-change in linear growth and body composition among 6-year-old children.

    Design: Children's data were collected from Copenhagen (Denmark), during 2001-2002, and again 3 years later. Boys and girls were separated into normal weight and overweight, based on BMI quintiles. Fat-free mass index (FFMI) and fat mass index (FMI) were calculated. Associations between change (Delta) in height, FMI and FFMI, respectively, and habitual PROT intake as well as ARG and LYS were analysed by multiple linear regressions, adjusted for baseline height, FMI or FFMI and energy intake, age, physical activity and socio-economic status.

    Setting: Eighteen schools in two suburban communities in the Copenhagen (Denmark) area participated in the study. SUBJECTS: In all, 223 children's data were collected for the present study.

    Results: High ARG intake was associated with linear growth (beta = 1.09 (se 0.54), P = 0.05) among girls. Furthermore, in girls, DeltaFMI had a stronger inverse association with high ARG intake, if it was combined with high LYS intake, instead of low LYS intake (P = 0.03). No associations were found in boys.

    Conclusion: In prepubertal girls, linear growth may be influenced by habitual ARG intake and body fat gain may be relatively prevented over time by the intake of the amino acids ARG and LYS.

  • 42525. van Vught, Anneke J. A. H.
    et al.
    Heitmann, Berit L.
    Nieuwenhuizen, Arie G.
    Veldhorst, Margriet A. B.
    Brummer, Robert
    Örebro universitet, Hälsoakademin.
    Westerterp-Plantenga, Margriet S.
    Association between dietary protein and change in body composition among children (EYHS)2009Inngår i: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 28, nr 6, s. 684-688Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND & AIMS: Growth hormone (GH) affects body composition by a relatively reduced fat mass and increased fat free mass. The intake of protein as well as the specific amino acids arginine and lysine potently stimulate GH secretion. This study investigated associations between intakes of protein, arginine, lysine and subsequent 6-year change in body composition among 8-10-year-old children.

    METHODS: Data of 364 children were collected from Odense, Denmark, during 1997-1998 and 6-year later as part of the European Youth Heart Study. Body mass index among children was subdivided by fat free mass index (FFMI) and fat mass index (FMI), based on skinfold measurements. Dietary intake was estimated via 24h recall. Associations between intakes of protein as well as arginine, lysine and change in FFMI and FMI were analysed by multiple linear regressions, adjusted for social economic status, puberty stage and physical activity level.

    RESULTS: Among lean girls inverse associations were found between protein as well as arginine and lysine intake and change in fat mass index (beta=-1.12+/-0.56, p=0.03, beta=-1.10+/-0.53, p=0.04, beta=-1.13+/-0.51, p=0.03 respectively). Furthermore among girls with a body mass index in the 5th quintile, protein intake was associated with DeltaFFMI (p=0.04), and more specific when LYS intake was high, ARG intake was associated with DeltaFFMI (p=0.04).

    CONCLUSION: Among girls high protein intakes may decrease body fat gain and increase fat free mass gain, depending on the available amounts and combinations of arginine and lysine.

  • 42526. van Vught, Anneke J. A. H.
    et al.
    Nieuwenhuizen, Arie G.
    Brummer, Robert
    Örebro universitet, Hälsoakademin.
    Westerterp-Plantenga, Margriet S.
    Effects of oral ingestion of amino acids and proteins on the somatotropic axis2008Inngår i: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 93, nr 2, s. 584-590Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    CONTEXT: GH is an important regulator of growth and body composition. It has been shown that GH release can be promoted by iv as well as oral administration of various amino acids (AAs), especially arginine (ARG) and lysine (LYS), which are amply present in soy protein. However, the effects of dietary protein on GH secretion are less well described. OBJECTIVE AND DESIGN: In an experiment, we compared the effects of oral ingestion of a mixture reflecting the AA composition of soy protein (AA), with oral ingestion of ARG + LYS, on GH secretion in eight healthy women (body mass index 19-25 kg/m(2); age, 18-24 yr). In a second experiment, we compared oral ingestion of hydrolyzed soy protein and complete soy protein with the AA mixture on GH secretion in eight healthy women (body mass index 19-26 kg/m(2); age, 19-36 yr). Both experiments were performed in a randomized, single-blind crossover design. GH, insulin, glucose, and plasma AA were determined every 20 min, during 3 h in the first experiment and during 5 h in the second experiment. RESULTS: Peak values of GH were higher after ingestion of the AA mixture compared with ingestion of ARG + LYS (P < 0.05). GH responses, as determined by area under the curve, did not significantly differ after ingestion of the complete soy protein, hydrolyzed soy protein, or AA mixture but were all higher than after placebo (P < 0.05). Insulin responses (area under the curve) were higher after ingestion of hydrolyzed soy protein, complete soy protein, and AA mixture, compared with placebo (P < 0.05). Glucose concentrations were unaffected. CONCLUSION: Ingestion of soy protein, either hydrolyzed or intact, as well as AAs reflecting soy protein, stimulates GH release to a similar extent.

  • 42527. van Vught, Anneke J. A. H.
    et al.
    Nieuwenhuizen, Arie G.
    Brummer, Robert
    Örebro universitet, Hälsoakademin.
    Westerterp-Plantenga, Margriet S.
    Somatotropic responses to soy protein alone and as part of a meal2008Inngår i: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 159, nr 1, s. 15-18Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    CONTEXT: GH is an important regulator of growth and body composition. We previously showed that GH release can be promoted by oral ingestion of soy protein; it is not known, however, whether these somatotropic effects of soy protein are also present when soy protein is ingested as part of a complete meal. OBJECTIVE/DESIGN: We compared the effects of oral ingestion of soy protein alone with the effects of a meal containing the same amount of soy protein on GH secretion in six healthy women (body mass index 19-26 kg/m(2), 19-36 years), in a randomized crossover design. During the whole experiment, serum GH, insulin, and glucose were determined every 20 min. RESULTS: GH responses as determined by area under the curve (AUC) and peak values were lower after ingestion of the meal, in comparison with GH responses after the soy protein consumption alone (P<0.05), and did not differ from the placebo. Glucose and insulin responses, both determined as AUC and peak values, were higher after ingestion of the meal, compared with those after ingestion of the protein drink or the placebo (P<0.05). CONCLUSION: The somatotropic effect of soy protein is reduced and delayed when soy protein is ingested as part of a complete meal. Dietary carbohydrates, by increasing serum levels of glucose and insulin concentration, as well as dietary fat, may have interfered with the somatotropic effects of soy protein.

  • 42528. van Vught, Anneke J. A. H.
    et al.
    Nieuwenhuizen, Arie G.
    Gerver, Willem-Jan
    Veldhorst, Margriet A. B.
    Brummer, Robert
    Örebro universitet, Hälsoakademin.
    Westerterp-Plantenga, Margriet S.
    Pharmacological and physiological growth hormone stimulation tests to predict successful GH therapy in children2009Inngår i: Journal of Pediatric Endocrinology & Metabolism (JPEM), ISSN 0334-018X, E-ISSN 2191-0251, Vol. 22, nr 8, s. 679-694Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Although the current use of growth hormone (GH) stimulation tests (GHSTs) is still subject to debate, the tests are widely used to diagnose GH deficiency. This literature review evaluates primarily the sensitivity, specificity and reliability of GHSTs and secondarily their convenience. Single pharmacological tests typically address only a single pathway in the complex physiological regulation of GH secretion and are therefore characterized by lower sensitivity, specificity and reliability than combined pharmacological tests or physiological tests. In spite of the high levels of sensitivity, specificity and reliability, physiological tests require considerably more effort to perform, from the physician as well as from the child. Therefore, a need for an alternative, convenient, physiological GHST still remains. Oral ingestion of dietary protein is convenient in practice and may induce more physiological stimulation of GH secretion, hence may be a promising valuable addition to the existing GHSTs in GH deficiency.

  • 42529.
    van Waalwijk van Doorn, Linda J. C.
    et al.
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands .
    Freund-Levi, Yvonne
    Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.
    Verbeek, Marcel M.
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands .
    Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes2017Inngår i: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 56, nr 2, s. 543-555Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Cerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer's disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., Aβ42, total tau (t-tau), and phosphorylated tau (p-tau), is affected by differences in lateral ventricular volume (VV), using CSF biomarker data and magnetic resonance imaging (MRI) scans of 730 subjects, from 13 European Memory Clinics. We developed a Matlab-algorithm for standardized automated segmentation analysis of T1 weighted MRI scans in SPM8 for determining VV, and computed its ratio with total intracranial volume (TIV) as proxy for total CSF volume. The diagnostic power of CSF biomarkers (and their combination), either corrected for VV/TIV ratio or not, was determined by ROC analysis. CSF Aβ42 levels inversely correlated to VV/TIV in the whole study population (Aβ42: r = -0.28; p < 0.0001). For CSF t-tau and p-tau, this association only reached statistical significance in the combined MCI and AD group (t-tau: r = -0.15; p-tau: r = -0.13; both p < 0.01). Correction for differences in VV/TIV improved the differentiation of AD versus controls based on CSF Aβ42 alone (AUC: 0.75 versus 0.81) or in combination with t-tau (AUC: 0.81 versus 0.91). In conclusion, differences in VV may be an important confounder in interpreting CSF Aβ42 levels.

  • 42530.
    van Weele, Arjan J.
    et al.
    Eindhoven University of Technology, Eindhoven, the Netherlands.
    Arbin, Katarina
    Örebro universitet, Handelshögskolan vid Örebro Universitet. Forever Sustainable Business Nordic AB.
    Inköp och Supply Chain Management: Analys, strategi, planering och praktik2019 (oppl. 2)Bok (Annet vitenskapelig)
    Abstract [sv]

    Inköp och supply chain management ger en introduktion till de centrala principerna inom området genom att anlägga ett brett ledningsperspektiv.

    Denna nya utgåva beskriver den senaste utvecklingen inom inköp och supply chain management och presenterar en rad relevanta och intressanta fallstudier tänkta att berika läsningen. Med hjälp av exempel från företag som Shell, Hewlett Packard, Mattel och Nespresso illustreras de typiska utmaningar som dagens globala organisationer ställs inför varje dag när det gäller inköp och supply chain management.

    Centrala områden:

    • En grundlig redogörelse av den senaste utvecklingen inom inköp och supply chain management, inklusive den cirkulära ekonomin.

    • En mer ingående genomgång av inköp och affärsstrategi samt CSR (corporate social responsibility).

    • Nya fallstudier som ger en ökad förståelse av inköp i praktiken.

    • De senaste förändringarna i europeisk upphandlingslagstiftning.

    • Utförliga diskussioner om partnerskap och samarbetsinriktade leverantörsrelationer.

  • 42531.
    Van Zalk, Maarten
    Örebro universitet.
    Online and Offline Friendships: The Roles of Social Anxiety and Self-esteemInngår i: Journal of personality, ISSN 0022-3506, E-ISSN 1467-6494Artikkel i tidsskrift (Fagfellevurdert)
  • 42532.
    Van Zalk, Maarten
    Örebro universitet.
    Psychopathic Traits and Violent Behaviors: The Role of Peers.Inngår i: Developmental Psychology, ISSN 0012-1649, E-ISSN 1939-0599Artikkel i tidsskrift (Annet vitenskapelig)
  • 42533.
    van Zalk, Maarten H. W.
    et al.
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Branje, Susan J. T.
    Denissen, Jaap
    van Aken, Marcel A. G.
    Meeus, Wim H. J.
    Who benefits from chatting, and why?: the roles of extraversion and supportiveness in online chatting and emotional adjustment2011Inngår i: Personality and Social Psychology Bulletin, ISSN 0146-1672, E-ISSN 1552-7433, Vol. 37, nr 9, s. 1202-1215Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The current study aimed to provide more insight into the role of online chatting in young adults’ emotional adjustment. A model was tested that takes into account (a) extraversion of individuals who communicate online, (b) the kind of peers these individuals communicate with online (i.e., online-exclusive peers vs. friends), and (c) the extent to which effects of online chatting on emotional adjustment are mediated by individuals’ ability to provide support to others. Young adults (age M = 18.9) filled out questionnaires about themselves and their fellow students at three measurements with a 4-month interval. Results showed that only for less extraverted individuals, chatting with peers found exclusively online directly predicted higher self-esteem and indirectly predicted less depressive symptoms through increases in supportiveness. Thus, results supported a model of social compensation where effects of online chatting with online-exclusive peers improved young adults’ emotional adjustment.

  • 42534.
    van Zalk, Maarten Herman Walter
    et al.
    Res Ctr Adolescent Dev, Univ Utrecht, Utrecht, Netherlands.
    Kerr, Margaret
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete. Ctr Adolescent Res, Univ Örebro, Örebro, Sweden.
    Developmental trajectories of prejudice and tolerance toward immigrants from early to late adolescence2014Inngår i: Journal of Youth and Adolescence, ISSN 0047-2891, E-ISSN 1573-6601, Vol. 43, nr 10, s. 1658-1671Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Adolescence is an important period for the development of relationships between immigrants and non-immigrants, yet little is known about how problematic personality traits affect adolescents' relationships with and attitudes toward immigrants. This work identified the roles of intergroup relationships and one dimension of problematic personality traits, namely callous-unemotional traits, in the development of adolescents' tolerance and prejudice. Three annual measurements of a large community sample (N = 1,542) of non-immigrant adolescents (M (age) = 15.31 at first measurement; 50.2 % girls) were used to show that tolerance and prejudice toward immigrants represent two dimensions with distinct developmental trajectories from early to late adolescence. Callous-unemotional traits predicted fewer decreases in prejudice toward immigrants, yet were not directly associated with tolerance. Intergroup friendships predicted stronger increases in tolerance, which, in turn, predicted decreases in prejudice toward immigrants. Thus, tolerance and prejudice toward immigrants seem to be differentially influenced by social experiences and problematic personality traits.

  • 42535.
    van Zalk, Maarten Herman Walter
    et al.
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Kerr, Margaret
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Branje, Susan J. T.
    Research Centre for Adolescent Development, Utrecht University, Utrecht, Netherlands.
    Stattin, Håkan
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Meeus, Wim H. J.
    Research Centre for Adolescent Development, Utrecht University, Utrecht, Netherlands.
    It takes three: selection, influence, and de-selection processes of depression in adolescent friendship networks2010Inngår i: Developmental Psychology, ISSN 0012-1649, E-ISSN 1939-0599, Vol. 46, nr 4, s. 927-938Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The authors of this study tested a selection influence de-selection model of depression. This model explains friendship influence processes (i.e., friends' depressive symptoms increase adolescents' depressive symptoms) while controlling for two processes: friendship selection (i.e., selection of friends with similar levels of depressive symptoms) and friendship de-selection (i.e., de-selection of friends with dissimilar levels of depressive symptoms). Further, this study is unique in that these processes were studied both inside and outside the school context. The authors used a social network approach to examine 5 annual measurements of data in a large (N = 847) community-based network of adolescents and their friends (M = 14.3 years old at first measurement). Results supported the proposed model: adolescents tend to select friends with similar levels of depression, and friends may increase each other's depressive symptoms as relationships endure. These two processes were most salient outside the school context. At the same time, friendships seemed to be ended more frequently if adolescents' level of depressive symptoms was dissimilar to that of their friends.

  • 42536.
    van Zalk, Maarten Herman Walter
    et al.
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Kerr, Margaret
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Branje, Susan J. T.
    Res Ctr Adolescent Dev, Univ Utrecht, Utrecht, Netherlands.
    Stattin, Håkan
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Meeus, Wim H. J.
    Res Ctr Adolescent Dev, Univ Utrecht, Utrecht, Netherlands.
    Peer contagion and adolescent depression: the role of failure anticipation2010Inngår i: Journal of clinical child and adolescent psychology (Print), ISSN 1537-4416, E-ISSN 1537-4424, Vol. 39, nr 6, s. 837-848Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The current study investigated the mechanisms underlying peer contagion of depressive symptoms in adolescence. Five annual measurements of data were gathered from a large (N=842) community-based network of adolescents (M=14.3 years at first measurement). Results showed that, after controlling for selection and deselection of friends on the basis of depressive symptoms, peers' depressive symptoms predicted increases in adolescents' depressive symptoms over time. Failure anticipation mediated effects of peers' depressive symptoms on adolescents' depressive symptoms, particularly for girls. Thus, results suggest that peers' depressive symptoms place adolescents at risk of developing depressive symptoms through increasing in failure anticipation.

  • 42537.
    Van Zalk, Maarten Herman Walter
    et al.
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Van Zalk, Nejra
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Kerr, Margaret
    Res Dev Ctr, Univ Örebro, Örebro, Sweden.
    Stattin, Håkan
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Influences Between Online-Exclusive, Conjoint and Offline-Exclusive Friendship Networks: The Moderating Role of Shyness2014Inngår i: European Journal of Personality, ISSN 0890-2070, E-ISSN 1099-0984, Vol. 28, nr 2, s. 134-146Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Prior research has indicated that shy adolescents are more motivated to form friendships online than to form friendships offline. Little is known about whether having friendships found exclusively online may impact self-esteem and forming offline friendships for these adolescents. This study therefore aimed to provide insight into the moderating role of shyness in the longitudinal interplay between friendships in online and offline contexts in early adolescence. Adolescents and their friends (193 girls, 196 boys; M-age = 13.29) were followed with three consecutive measurements with intervals of eight months. Results showed that particularly for shy adolescents, having friends exclusively online predicted increases in self-esteem. Self-esteem, in turn, was found to predict forming more friendships found both offline and online and forming more friendships found exclusively offline. Thus, findings supported the social compensation perspective that shy adolescents may benefit from having friends exclusively online, as these friendships may increase self-esteem, thereby facilitating the formation of friendships found partially and completely offline. Copyright (c) 2013 John Wiley & Sons, Ltd.

  • 42538.
    Van Zalk, Maarten
    et al.
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Kerr, Margaret
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    How Online and Offline Friends Influence DelinquencyInngår i: European Journal of Personality, ISSN 0890-2070, E-ISSN 1099-0984Artikkel i tidsskrift (Annet vitenskapelig)
  • 42539.
    Van Zalk, Maarten
    et al.
    Örebro universitet.
    Kerr, Margaret
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Stattin, Håkan
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    What is going on in antisocial networks? The roles of peers and family processesInngår i: Journal of clinical child psychology, ISSN 0047-228X, E-ISSN 1532-7639Artikkel i tidsskrift (Fagfellevurdert)
  • 42540.
    van Zalk, Maarten
    et al.
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Kerr, Margaret
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    van Zalk, Nejra
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Stattin, Håkan
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Xenophobia and tolerance toward immigrants in adolescence: cross-influence processes within friendships2013Inngår i: Journal of Abnormal Child Psychology, ISSN 0091-0627, E-ISSN 1573-2835, Vol. 41, nr 4, s. 627-639Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    To what extent do adolescents and their friends socialize each others' attitudes toward immigrants? Can friends' positive attitudes toward immigrants counter adolescents' negative attitudes toward immigrants, and do friends' negative attitudes decrease adolescents' positive attitudes? These questions were examined by following a large (N = 1,472) friendship network of adolescents (49.2 % girls; M (age) = 13.31 at first measurement) across three annual measurements. Selection and influence processes regarding tolerance and xenophobia were distinguished with longitudinal social network analyses, controlling for effects of age, gender, and immigrant background. Findings showed that friends' tolerance predicted increases in adolescents' tolerance and friends' xenophobia predicted increases in adolescents' xenophobia. Moreover, friends' tolerance predicted a lower likelihood of adolescents' xenophobia increasing. The current results suggest that interventions should distinguish between tolerance and xenophobia, as these appear to represent two separate dimensions that are each influenced in specific ways by friends' tolerance and xenophobia.

  • 42541.
    Van Zalk, M.H.W.
    et al.
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Kerr, Margaret
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Callous-Unemotional Traits in Adolescents: Cross-Influence Processes in FriendshipInngår i: Journal of Abnormal Child Psychology, ISSN 0091-0627, E-ISSN 1573-2835Artikkel i tidsskrift (Annet vitenskapelig)
  • 42542.
    Van Zalk, M.H.W.
    et al.
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Kerr, Margaret
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Psychopathic Traits and Antisocial Behaviors in AdolescenceInngår i: Journal of personality, ISSN 0022-3506, E-ISSN 1467-6494Artikkel i tidsskrift (Annet vitenskapelig)
  • 42543.
    Van Zalk, Nejra
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Social anxiety moderates the links between excessive chatting and compulsive Internet use2016Inngår i: Cyberpsychology : Journal of Psychosocial Research on Cyberspace, ISSN 1802-7962, E-ISSN 1802-7962, Vol. 10, nr 3, artikkel-id UNSP 3Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Excessive online chatting can lead to unwanted consequences such as compulsive Internet use over time. Not all adolescents use chatting for the same purpose, however, and these links may not be as pronounced for socially anxious adolescents as they likely communicate with others online in order to compensate for offline social inadequacies. The current study investigated whether social anxiety moderated the links between excessive chatting and compulsive Internet use over time. Using a sample of 523 early adolescents (269 girls; M-age = 14.00) from a 3-wave longitudinal study, the links between excessive chatting and compulsive Internet use were investigated via manifest autoregressive models, and moderating effects of social anxiety were tested via multiple group comparison procedures. The results showed bidirectional links between excessive chatting and compulsive Internet use from Time 2-Time 3, as excessive chatting predicted more symptoms of compulsive Internet use, whereas compulsive Internet use predicted more excessive chatting-over and above the effects of gender. These links were present for adolescents low on social anxiety, but they were largely missing for highly socially anxious adolescents. Thus, social anxiety may have protective effects for early adolescents who spend too much time chatting online, as it may help reduce the risk of developing symptoms of compulsive Internet use.

  • 42544.
    van Zalk, Nejra
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    The role of parents, peers, and personality on the impact of media use on youths' emotional adjustment2010Annet (Annet vitenskapelig)
  • 42545.
    van Zalk, Nejra
    et al.
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Kerr, Margaret
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Shy adolescents' perceptions of parents' psychological control and emotional warmth: examining bidirectional links2011Inngår i: Merrill-Palmer quarterly, ISSN 0272-930X, E-ISSN 1535-0266, Vol. 57, nr 4, s. 375-401Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Two kinds of parental behaviors—psychological control and emotional warmth—have been linked with children's shy behaviors. The questions we addressed are whether this applies to adolescent shyness, and whether shyness in itself might also affect perceptions of parental behaviors. The participants were 916 seventh to ninth graders in a longitudinal project. We used a cross-lagged panel model with three time points in MPlus with adolescents' self-reports of shyness and perceptions of parents' psychological control (intrusive control and rejection) and warmth. Shyness predicted an increase in perceptions of intrusive control by parents at Time 2, which then predicted an increase in shyness at Time 3. Shyness also predicted an increase in perceived rejection by parents at Time 2. Finally, shyness predicted decreases in parental warmth at both time points. The effects did not differ for boys and girls. These results show that adolescent shyness predicts parental behaviors, though perhaps less strongly than in childhood. They also suggest some bidirectional effects in which perceived parental responses to shy youths might serve to strengthen the shyness.

  • 42546.
    van Zalk, Nejra
    et al.
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Kerr, Margaret
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Shy punks, goths, and other eye-catching peer crowds: are they more prone to problem behavior than other shy youths?2010Konferansepaper (Fagfellevurdert)
  • 42547.
    van Zalk, Nejra
    et al.
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Kerr, Margaret
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Tilton-Weaver, Lauree
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Shyness as a moderator of the link between advanced maturity and early adolescent risk behavior2011Inngår i: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 52, nr 4, s. 341-353Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Advanced maturity in early adolescence has previously been linked with several risk behaviors. In this study, we examine whether shyness and gender might moderate this link. The participants were 750 early adolescents (Mage = 13.73; 390 girls and 360 boys), followed for one year. We conducted analyses with shyness and gender as moderators of the links between advanced maturity and different types of risk behavior, and between one risk behavior and another. Despite differential patterns for boys and girls, the results suggest that being shy or not being shy modifies the links between advanced maturity and risk behavior primarily for boys. For boys, shyness reduces relationships between advanced maturity and risk behavior, whereas not being shy exacerbates the relationships between advanced maturity and high-risk behavior. Controlling for romantic involvement and peer victimization did not alter the moderating effects, thus failing to support the idea that the weaker links for shy youths were due to shy youths not being drawn into advanced peer groups by romantic partners or peers. Thus, shyness might serve as a buffer against risk behavior in early adolescence.

  • 42548.
    van Zalk, Nejra
    et al.
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Kerr, Margaret
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Tilton-Weaver, Lauree
    Örebro universitet, Akademin för juridik, psykologi och socialt arbete.
    Subjective maturity and risky behavior: is shyness a protective factor?2010Konferansepaper (Fagfellevurdert)
  • 42549.
    Van Zalk, Nejra
    et al.
    Department of Psychology, Social Work and Counselling, University of Greenwich, London, United Kingdom.
    Tillfors, Maria
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Co-rumination buffers the link between social anxiety and depressive symptoms in early adolescence2017Inngår i: Child and Adolescent Psychiatry and Mental Health, ISSN 1753-2000, E-ISSN 1753-2000, Vol. 11, nr 1, artikkel-id 41Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: We examined whether co-rumination with online friends buffered the link between social anxiety and depressive symptoms over time in a community sample.

    Methods: In a sample of 526 participants (358 girls; M-age = 14.05) followed at three time points, we conducted a latent cross-lagged model with social anxiety, depressive symptoms, and co-rumination, controlling for friendship stability and friendship quality, and adding a latent interaction between social anxiety and co-rumination predicting depressive symptoms.

    Results: Social anxiety predicted depressive symptoms, but no direct links between social anxiety and co-rumination emerged. Instead, co-rumination buffered the link between social anxiety and depressive symptoms for adolescents with higher but not lower levels of social anxiety.

    Conclusions: These findings indicate that co-rumination exerted a positive influence on interpersonal relationships by diminishing the influence from social anxiety on depressive symptoms over time.

  • 42550.
    Van Zalk, Nejra
    et al.
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Van Zalk, Maarten
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    The importance of perceived care and connectedness with friends and parents for adolescent social anxiety2015Inngår i: Journal of personality, ISSN 0022-3506, E-ISSN 1467-6494, Vol. 83, nr 3, s. 346-360Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Nonclinical social anxiety in adolescence can be highly problematic, as it likely affects current and especially new social interactions. Relationships with significant others, such as close friends, mothers, and fathers, could aid socially anxious adolescents' participation in social situations, thereby helping reduce feelings of social anxiety. We examined whether making friends as well as high friendship quality help reduce social anxiety over time, and whether friends', mothers', and fathers' care interact in reducing social anxiety. Using longitudinal data from 2,194 participants in a social network (48% girls; Mage  = 13.58) followed for 3 years, we estimated friendship selection and influence processes via a continuous time-modeling approach using SIENA. We controlled for the effects of depressive symptoms, self-esteem, gender, age, and family structure. Our findings suggest that perceived care by friends mediated the effect of making friends on social anxiety. Perceptions of mother and father, as well as friend care and connectedness, respectively, did not interact in decreasing social anxiety. Nonetheless, care and connectedness with mothers, fathers, and friends jointly predicted decreases in social anxiety. Caring relationships with friends and parents each play a role in mutually protecting early adolescents against increasing in social anxiety over time.

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