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  • 42851.
    Tuvblad, Catherine
    et al.
    Department of Psychology, University of Southern California, Los Angeles, California, USA.
    Raine, Adrian
    Departments of Criminology, Psychiatry, and Psychology, University of Pennsylvania, Pennsylvania, Philadelphia, USA.
    Zheng, Mo
    Department of Psychology, University of Southern California, Los Angeles, California, USA.
    Baker, Laura A.
    Department of Psychology, University of Southern California, Los Angeles, California, USA.
    Genetic and environmental stability differs in reactive and proactive aggression2009In: Aggressive Behavior, ISSN 0096-140X, E-ISSN 1098-2337, Vol. 35, no 6, p. 437-452Article in journal (Refereed)
    Abstract [en]

    The aim of this study was to examine stability and change in genetic and environmental influences on reactive (impulsive and affective) and proactive (planned and instrumental) aggression from childhood to early adolescence. The sample was drawn from an ongoing longitudinal twin study of risk factors for antisocial behavior at the University of Southern California (USC). The twins were measured on two occasions: ages 9-10 years (N=1,241) and 11-14 years (N=874). Reactive and proactive aggressive behaviors were rated by parents. The stability in reactive aggression was due to genetic and nonshared environmental influences, whereas the continuity in proactive aggression was primarily genetically mediated. Change in both reactive and proactive aggression between the two occasions was mainly explained by nonshared environmental influences, although some evidence for new genetic variance at the second occasion was found for both forms of aggression. These results suggest that proactive and reactive aggression differ in their genetic and environmental stability, and provide further evidence for some distinction between reactive and proactive forms of aggression.

  • 42852.
    Tuvblad, Catherine
    et al.
    Örebro University, School of Law, Psychology and Social Work.
    Sild, Mari
    Concordia University, Montreal, Canada.
    Frogner, Louise
    Örebro University, School of Law, Psychology and Social Work.
    Booij, Linda
    Concordia University, Montreal, Canada.
    Behavioral Genetics of Aggression and Intermittent Explosive Disorder2019In: Intermittent Explosive Disorder: Etiology, Assessment, and Treatment / [ed] Emil Coccaro, Michael McCloskey, Academic Press, 2019, p. 17-35Chapter in book (Other academic)
    Abstract [en]

    Aggression has been consistently shown to have a large genetic component based on findings from behavioral genetic studies. However, candidate gene and GWA studies on aggression have not identified a significant genetic marker. This does not mean that there are no genes relevant for aggression, but possibly indicates a complex interplay between various genetic components and environmental factors/triggers in aggression. Additionally, distinct forms of aggressive behavior (e.g., reactive, proactive, direct /physical, indirect/relational) may differ in their underlying neurobiological mechanisms. The extent to which environment affects epigenetic processes may depend on genotype, as well as other factors such as age, sex, and developmental history. The nonlinear occurrence of aggression over the lifetime (. Petersen, Bates, Dodge, Lansford, & Pettit, 2015) hints the involvement of developmental processes in the manifestation of aggression. Also, pathological aggression is highly comorbid with numerous psychiatric disorders and the concept of aggression is very heterogeneous, which further increases the complexity in the search for genetic and epigenetic markers. Notably, while most clinical studies focus on antisocial personality disorder, (epi)genetic research in psychiatric disorders that have aggression as a core symptom (such as IED) is scarce. Multidisciplinary collaborative research of genetic and epigenetic factors at various ages throughout the lifespan in well-characterized clinical and nonclinical study samples is needed to further shed light on the specific genetic and epigenetic contributions to (different types of) aggression including IED.

  • 42853.
    Tuvblad, Catherine
    et al.
    Örebro University, School of Law, Psychology and Social Work. Department of Psychology, University of Southern California, Los Angeles CA, United States.
    Wang, Pan
    Department of Psychology, University of Southern California, Los Angeles CA, United States.
    Bezdjian, Serena
    Department of Psychology, University of Southern California, Los Angeles CA, United States.
    Raine, Adrian
    University of Pennsylvania, Philadelphia, United States.
    Baker, Laura A.
    Department of Psychology, University of Southern California, Los Angeles CA, United States.
    Psychopathic personality development from ages 9 to 18: genes and environment2016In: Development and psychopathology (Print), ISSN 0954-5794, E-ISSN 1469-2198, Vol. 28, no 1, p. 27-44Article in journal (Refereed)
    Abstract [en]

    The genetic and environmental etiology of individual differences was examined in initial level and change in psychopathic personality from ages 9 to 18 years. A piecewise growth curve model, in which the first change score (G(1)) influenced all ages (9-10, 11-13, 14-15, and 16-18 years) and the second change score (G(2)) only influenced ages 14-15 and 16-18 years, fit the data better did than the standard single slope model, suggesting a turning point from childhood to adolescence. The results indicated that variations in levels and both change scores were mainly due to genetic (A) and nonshared environmental (E) influences (i.e., AE structure for G(0), G(1), and G(2)). No sex differences were found except on the mean values of level and change scores. Based on caregiver ratings, about 81% of variance in G(0), 89% of variance in G(1), and 94% of variance in G(2) were explained by genetic factors, whereas for youth self-reports, these three proportions were 94%, 71%, and 66%, respectively. The larger contribution of genetic variance and covariance in caregiver ratings than in youth self-reports may suggest that caregivers considered the changes in their children to be more similar as compared to how the children viewed themselves.

  • 42854.
    Tuvblad, Catherine
    et al.
    Department of Psychology, University of Southern California CA, USA.
    Wang, Pan
    University of California Los Angeles, Center for Health Policy Research CA, USA.
    Patrick, Christopher J
    Department of Psychology, Florida State University FL, USA.
    Berntsen, Leslie
    Department of Psychology, University of Southern California CA, USA.
    Raine, Adrian
    Departments of Criminology, Psychiatry, and Psychology, University of Pennsylvania, Philadelphia PA, USA.
    Baker, Laura A
    Department of Psychology, University of Southern California CA, USA.
    Genetic and environmental influences on disinhibition, boldness, and meanness as assessed by the triarchic psychopathy measure in 19-20-year-old twins2019In: Psychological Medicine, ISSN 0033-2917, E-ISSN 1469-8978, Vol. 49, no 9, p. 1500-1509Article in journal (Refereed)
    Abstract [en]

    Background: The Triarchic Psychopathy Measure (TriPM) provides Disinhibition, Boldness, and Meanness scales for assessing the three trait domains of the triarchic model. Here we examined the genetic and environmental etiology of these three domains, including evaluation of potential sex differences.

    Methods: A total of 1016 men and women ages 19–20 years were drawn from the University of Southern California Risk Factors for Antisocial Behavior twin study.

    Results: Scores for the three TriPM scales were correlated to differing degrees, with the strongest phenotypic correlation between Disinhibition and Meanness. No sex differences were found in the genetic and environmental influences underlying these three domains, suggesting that the same genes and life experiences contribute to these traits in young men and women. For TriPM Disinhibition and Boldness, genetic factors explained about half or less of the variance, with the rest of the variance being explained by non-shared environmental factors. For TriPM Meanness, on the other hand, genetic, shared environmental, and non-shared environmental factors accounted for the variance. The phenotypic correlation between Disinhibition and Meanness was explained in part by common genes (26%), with the remainder attributable about equally to common shared (39%), and non-shared environmental influences (35%).

    Conclusions: These findings contribute to our understanding of psychopathic personality traits by demonstrating the importance of heritable factors for disinhibition and boldness facets of psychopathy, and the importance of shared environmental influences for the meanness facet.

  • 42855.
    Tuvblad, Catherine
    et al.
    University of Southern California, Los Angeles, USA.
    Younan, Diana
    University of Southern California, Los Angeles, USA.
    Baker, Laura
    University of Southern California, Los Angeles, USA.
    Lurmann, Fred
    University of Southern California, Los Angeles, USA.
    Franklin, Meredith
    University of Southern California, Los Angeles, USA.
    Chen, Jiu-Chiuan
    University of Southern California, Los Angeles, USA.
    Neighborhood green space and substance use: a longitudinal cohort study in Southern California2014Conference paper (Other academic)
  • 42856.
    Tuvblad, Catherine
    et al.
    Department of Psychology, University of Southern California, Los Angeles, United States.
    Zheng, Mo
    Department of Psychology, University of Southern California, Los Angeles, United States.
    Raine, Adrian
    Departments of Criminology, Psychiatry, and Psychology, University of Pennsylvania, Los Angeles, United States .
    Baker, Laura A.
    Department of Psychology, University of Southern California, Los Angeles, United States.
    A common genetic factor explains the covariation among ADHD ODD and CD symptoms in 9-10 year old boys and girls2009In: Journal of Abnormal Child Psychology, ISSN 0091-0627, E-ISSN 1573-2835, Vol. 37, no 2, p. 153-167Article in journal (Refereed)
    Abstract [en]

    Previous studies examining the covariation among Attention Deficit Hyperactivity Disorder (ADHD), Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) have yielded inconsistent results. Some studies have concluded that the covariation among these symptoms is due to common genetic influences, whereas others have found a common environmental overlap. The present study investigated the genetic and environmental correlations among these three childhood disorders, based on a sample of 1,219 twins, age 9-10 years. A latent externalizing behavior factor was found to explain the covariance among ADHD, ODD and CD symptoms. Genetic influences explained more than half of the variance in this externalizing factor in both boys and girls. There were also unique genetic and environmental influences in each set of symptoms, suggesting some etiological independence of the three disorders. Our findings have implications for molecular genetic studies trying to identify susceptibility genes for these disorders.

  • 42857.
    Tuveson, Viktoria
    Örebro University, School of Medicine, Örebro University, Sweden.
    THE PREVALENCE OF POPLITEAL ARTERY ANEURYSMS IN PATIENTS WITH ABDOMINAL AORTIC ANEURYSMS Author:2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 42858.
    Tuvesson, Viktoria
    Örebro University, School of Medical Sciences.
    PREVALENCE OF POPLIEAL ARTERY ANEURYSMS IN PATIENTS WITH ABDOMINAL AORTIC ANEURYSMS2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • 42859.
    Tuza, Adam
    Örebro University, School of Law, Psychology and Social Work.
    Avhopparverksamhet: Vägen ur gatugänget2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Street gangs, internationally and nationally, contributing to major social problems, authorities have given priority to preventive measures in the form of exitprograms. This study would examine how exitprgoram staff, in a medium-sized Swedish city, experiencing its authority and work in shaping local guidelines and practices. The study was conducted through a qualitative method where the selection of data collection was done through semi-structured interviews. Police have national guidelines regarding who may be part of a exitprogram however, relates to the local police guidelines in the work. The social workers only relate to local guidelines. The work process is divided into three phases where the first two phases are organized and structured to then move to a flexible and unstructured approach

  • 42860.
    Tuza, Nicholette
    Örebro University, School of Law, Psychology and Social Work.
    Rättssäkerhet inom förvaltningsorganisationen: en studie om handläggningstiden av ärenden avseende personlig assistans2011Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
  • 42861.
    Tveit, Sverre
    et al.
    Department of Education, University of Agder, Kristiansand, Norway.
    Lundahl, Christian
    Örebro University, School of Humanities, Education and Social Sciences.
    New modes of policy legitimation in education: (Mis)using comparative data to effectuate assessment reform2018In: European Educational Research Journal (online), ISSN 1474-9041, E-ISSN 1474-9041, Vol. 17, no 5, p. 631-655Article in journal (Refereed)
    Abstract [en]

    Identifying three modes of policy legitimation in education, illustrated by shifts in Swedish educational assessment and grading policies over the past decades, the article demonstrates significant trends with regards to national governments’ policymaking and borrowing. We observe a shift away from collaboracy—defined as policy legitimation located in partnership and networks of stakeholders, researchers and other experts—towards more use of supranational agencies (called agency), such as the OECD, the European Union and associated networks, as well as the use of individual consultants and private enterprises (called consultancy) to legitimate policy change. Analysing assessment and grading policies reported in Eurydice, the paper discusses functional equivalence of grading policies and validity problems related to the construction and use of policy comparisons. Illuminating the Swedish government and a consultant’s role in reviewing and recommending grading policies, the paper discusses new ‘fast policy’ modes of policy legitimation utilising comparative data to effectuate assessment reform.

  • 42862.
    Tverling, Martin
    et al.
    Örebro University, School of Humanities, Education and Social Sciences.
    Liljekvist, Hans
    Örebro University, School of Humanities, Education and Social Sciences.
    Elevperspektiv på skolkonferensen: En kvalitativ studie av inflytande och deltagande i gymnasieskolans skolkonferens2010Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 42863.
    Twizeyimana, Jean Damascene
    Örebro University, Örebro University School of Business.
    E-Government and Value Creation in the Context of a Least Developed Country: A perspective on public value and information infrastructure2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis is in the field of information systems (IS), more specifically about IS impact. This thesis uses literature review and interpretive case study methods to investigate the phenomenon of value creation through e-government.

    The research was carried out from 2014 to 2019. Data was collected through interviews, participant observations, and document review. The main research question is "How do we create value through e-government in the context of an LDC?” It embodies the sub-questions: what is the value of e-government? And how do we attain such value?

    This thesis comprises four studies.

    The thesis found that value creation of e-government is a process of understanding: the value that e-government creates; the context in which egovernment resides because a process involves a context; and strategic actions to create that value within the context surrounds e-government.

    From the findings, this thesis argues that the value of public affairs including e-government refers to public value. The latter would mean citizens' collective expectations about public policies and services. Also, the findings reveal research needs about the public value of e-government in the LDCs in Sub-Saharan Africa and on methods of measuring and creating the public value of e-government.

    As original contribution, this thesis suggests a framework of six overarching and overlapping areas of e-government for the public value. The anticipation-reality gaps and their inter-relationships are identified, and five inter-related critical success factors are suggested. Also, the information infrastructure (II) framework, particularly, the notion of the cultivation of the installed-base is suggested as a promising avenue in the management of the public value creation in general, and in an LDC in particular.

    List of papers
    1. The public value of E-Government: A literature review
    Open this publication in new window or tab >>The public value of E-Government: A literature review
    2019 (English)In: Government Information Quarterly, ISSN 0740-624X, E-ISSN 1872-9517, Vol. 36, no 2, p. 167-178Article, review/survey (Refereed) Published
    Abstract [en]

    This study organizes existing research on the public value of e-government in order to investigate the current state and what value e-government is supposed to yield. The two questions that guided the research were: (1) What is the current state of research on the public value of e-government? And (2) What value is e-government supposed to yield? Six, sometimes overlapping, values were found: Improved public services; improved administrative efficiency; Open Government (OG) capabilities; improved ethical behaviour and professionalism; improved trust and confidence in government; and improved social value and well-being. These six public value dimensions were thereafter generalized into three overarching, and also overlapping, public value dimensions of Improved Public Services, Improved Administration, and Improved Social Value. The improved public services dimension influences other dimensions. Hence, this literature study theorizes a descriptive and multidimensional framework that can improve our understanding of the public value of e-government from different viewpoints, and the overlap between them in actual e-government designs and implementations. Regarding the current state of research on the public value this study found a lack of research on the public value of e-government, especially, in the context of developing countries – and more importantly – a total absence of this kind of research in the Least Developed Countries (LDCs). There is also a lack of comparative studies at national, regional, and project level; and a lack of research on the generative perspective.

    Place, publisher, year, edition, pages
    Elsevier, 2019
    Keywords
    E-Government, Public value, IT value, Framework, Literature review
    National Category
    Information Systems, Social aspects
    Research subject
    Informatics
    Identifiers
    urn:nbn:se:oru:diva-73688 (URN)10.1016/j.giq.2019.01.001 (DOI)000467194300001 ()2-s2.0-85061541488 (Scopus ID)
    Available from: 2019-04-12 Created: 2019-04-12 Last updated: 2019-11-11Bibliographically approved
    2. The public value of e-Government: anticipations in the IREMBO project in Rwanda
    Open this publication in new window or tab >>The public value of e-Government: anticipations in the IREMBO project in Rwanda
    (English)Manuscript (preprint) (Other academic)
    National Category
    Information Systems, Social aspects
    Identifiers
    urn:nbn:se:oru:diva-77826 (URN)
    Available from: 2019-11-11 Created: 2019-11-11 Last updated: 2019-11-11Bibliographically approved
    3. E-government in Rwanda: Implementation, Challenges and Reflections
    Open this publication in new window or tab >>E-government in Rwanda: Implementation, Challenges and Reflections
    2018 (English)In: Electronic Journal of e-Government, ISSN 1479-439X, E-ISSN 1479-439X, Vol. 16, no 1, p. 19-31Article in journal (Refereed) Published
    Abstract [en]

    E‑government is currently high on the agenda in many developing countries (DCs). While e‑government is well‑established in many developed countries it is new to least developed countries. Countries that start implementing e‑government today can benefit from easy import of modern technologies, but adaptation to local conditions and the organizational change that is required cannot be imported, but must be developed at home. By using examples of an ongoing initiative by the Government of Rwanda to digitalize all G2C and G2B into a single window platform, the current study investigated the important challenges in the implementation of e‑government in Rwanda. An interpretive case study was followed. Data was collected through interviews and participatory observations during August to December 2015. Data analysis was inductive, the analysis method was content analysis, and the coding followed open‑coding. NVivo software has been used to handle data and facilitate the analysis. The study found six overarching categories of aspects that challenge a successful implementation of e‑government in Rwanda. They include information infrastructure for e‑government, social inclusion, governance, management, trust in the new system, and languages. However, challenges to e‑government implementation should not be taken as of the same extent, neither their degree of mitigation. Rather, they influence and are influenced by various contextual factors which include political support, nature of the e‑government project, implementation strategies, human and socio‑economic development, existing information infrastructure, and operational capabilities. Having said this, we also argue that countries should learn from one another of their experiences, success stories, and mistakes. Despite a number of associated challenges, the adopted public‑private partnership (PPP) approach to e‑Government implementation in Rwanda might indeed seem as a suitable catalyst for e‑government success in the country.

    2.5.0.0

    Place, publisher, year, edition, pages
    UK: Academic Conferences Limited, 2018
    Keywords
    information infrastructure, e-government, implementation, public-private partnership (PPP), least developed countries (LDCs), sub-Saharan Africa, Rwanda
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Research subject
    Informatics
    Identifiers
    urn:nbn:se:oru:diva-70165 (URN)
    Projects
    E-Government Implementation in Rwanda: the value and context
    Note

    2.5.0.0

    Available from: 2018-11-13 Created: 2018-11-13 Last updated: 2019-11-11Bibliographically approved
    4. Towards Realization of the Public Value of e-Government: anticipation-reality gap and critical success factors in the context of Rwanda
    Open this publication in new window or tab >>Towards Realization of the Public Value of e-Government: anticipation-reality gap and critical success factors in the context of Rwanda
    (English)Manuscript (preprint) (Other academic)
    National Category
    Information Systems, Social aspects
    Identifiers
    urn:nbn:se:oru:diva-77827 (URN)
    Available from: 2019-11-11 Created: 2019-11-11 Last updated: 2019-11-11Bibliographically approved
    Download full text (pdf)
    E-Government and Value Creation in the Context of a Least Developed Country
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  • 42864.
    Twizeyimana, Jean Damascene
    Örebro University, Örebro University School of Business. College of Science & Technology University of Rwanda, Kigali, Rwanda.
    Towards Realization of the Public Value of e-Government: anticipation-reality gap and critical success factors in the context of RwandaManuscript (preprint) (Other academic)
  • 42865.
    Twizeyimana, Jean Damascene
    Örebro University, Örebro University School of Business. College of Science and Technology, University of Rwanda, Kigali, Rwanda.
    User-centeredness and usability in e-government: a reflection on a case study in Rwanda2017In: eGose '17: Proceedings of the Internationsl Conference on Electronic Governance and Open Society: Challenges in Eurasia, Association for Computing Machinery (ACM), 2017, p. 172-178Conference paper (Refereed)
    Abstract [en]

    While e-government is well-established in many developed countries, it looks new to many least developed countries despite the fact that they have been using ICTs for decades. By using examples from a case study in Rwanda, the current study aims at contributing to existing efforts for minimizing risks of users to reject e-government systems in LDCs through proposing critical success factors for an improved implementation of a user-centered usable e-government. The study followed an interpretive case study approach to investigate a Rwandan government major development effort aiming at digitizing 100 e-government services. Data was collected through participatory observations in the period of August to December 2015. Data has been analyzed using literature on usability and user-centered design in egovernment. The findings suggests that the adopted public-private partnership (PPP) approach to e-Government implementation in Rwanda provides opportunities to achieve a user centered egovernment, and that user involvement in early stages would help to avoid basic flaws and increase users 'confidence and trust, and decrease their likelihood to reject e-government systems.

  • 42866.
    Twizeyimana, Jean Damascene
    et al.
    Örebro University, Örebro University School of Business. College of Science & Technology, University of Rwanda, KN 7 Ave, Kigali, Rwanda.
    Andersson, Annika
    Örebro University, Örebro University School of Business.
    The public value of E-Government: A literature review2019In: Government Information Quarterly, ISSN 0740-624X, E-ISSN 1872-9517, Vol. 36, no 2, p. 167-178Article, review/survey (Refereed)
    Abstract [en]

    This study organizes existing research on the public value of e-government in order to investigate the current state and what value e-government is supposed to yield. The two questions that guided the research were: (1) What is the current state of research on the public value of e-government? And (2) What value is e-government supposed to yield? Six, sometimes overlapping, values were found: Improved public services; improved administrative efficiency; Open Government (OG) capabilities; improved ethical behaviour and professionalism; improved trust and confidence in government; and improved social value and well-being. These six public value dimensions were thereafter generalized into three overarching, and also overlapping, public value dimensions of Improved Public Services, Improved Administration, and Improved Social Value. The improved public services dimension influences other dimensions. Hence, this literature study theorizes a descriptive and multidimensional framework that can improve our understanding of the public value of e-government from different viewpoints, and the overlap between them in actual e-government designs and implementations. Regarding the current state of research on the public value this study found a lack of research on the public value of e-government, especially, in the context of developing countries – and more importantly – a total absence of this kind of research in the Least Developed Countries (LDCs). There is also a lack of comparative studies at national, regional, and project level; and a lack of research on the generative perspective.

    Download full text (pdf)
    The public value of E-Government : A literature review
  • 42867.
    Twizeyimana, Jean Damascene
    et al.
    Örebro University, Örebro University School of Business. College of Science & Technology University of Rwanda, Kigali, Rwanda.
    Andersson, Annika
    Örebro University, Örebro University School of Business.
    The public value of e-Government: anticipations in the IREMBO project in RwandaManuscript (preprint) (Other academic)
  • 42868.
    Twizeyimana, Jean Damascene
    et al.
    Örebro University, Örebro University School of Business. College of Science & Technology University of Rwanda, Kigali, Rwanda.
    Larsson, Hannu
    Örebro University, Örebro University School of Business.
    Grönlund, Åke
    Örebro University, Örebro University School of Business.
    E-government in Rwanda: Implementation, Challenges and Reflections2018In: Electronic Journal of e-Government, ISSN 1479-439X, E-ISSN 1479-439X, Vol. 16, no 1, p. 19-31Article in journal (Refereed)
    Abstract [en]

    E‑government is currently high on the agenda in many developing countries (DCs). While e‑government is well‑established in many developed countries it is new to least developed countries. Countries that start implementing e‑government today can benefit from easy import of modern technologies, but adaptation to local conditions and the organizational change that is required cannot be imported, but must be developed at home. By using examples of an ongoing initiative by the Government of Rwanda to digitalize all G2C and G2B into a single window platform, the current study investigated the important challenges in the implementation of e‑government in Rwanda. An interpretive case study was followed. Data was collected through interviews and participatory observations during August to December 2015. Data analysis was inductive, the analysis method was content analysis, and the coding followed open‑coding. NVivo software has been used to handle data and facilitate the analysis. The study found six overarching categories of aspects that challenge a successful implementation of e‑government in Rwanda. They include information infrastructure for e‑government, social inclusion, governance, management, trust in the new system, and languages. However, challenges to e‑government implementation should not be taken as of the same extent, neither their degree of mitigation. Rather, they influence and are influenced by various contextual factors which include political support, nature of the e‑government project, implementation strategies, human and socio‑economic development, existing information infrastructure, and operational capabilities. Having said this, we also argue that countries should learn from one another of their experiences, success stories, and mistakes. Despite a number of associated challenges, the adopted public‑private partnership (PPP) approach to e‑Government implementation in Rwanda might indeed seem as a suitable catalyst for e‑government success in the country.

    2.5.0.0

    Download full text (pdf)
    E-government in Rwanda: Implementation, Challenges and Reflections
  • 42869.
    Tworek, Luiza
    Örebro University, School of Health Sciences.
    Development of a liquid chromatography - high resolution mass spectrometry method for multi-component screening of synthetic cannabinoids in blood.2016Independent thesis Advanced level (degree of Master (Two Years)), 10 credits / 15 HE creditsStudent thesis
    Download full text (pdf)
    Development of a liquid chromatography - high resolution mass spectrometry method for multi-component screening of synthetic cannabinoids in blood.
  • 42870.
    Tyekucheva, Svitlana
    et al.
    Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston MA, USA.
    Bowden, Michaela
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.
    Bango, Clyde
    Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston MA, USA.
    Giunchi, Francesca
    Department of Pathology, Addarii Institute of Oncology, S.Orsola-Malpighi Teaching Hospital, University of Bologna, Bologna, Italy.
    Huang, Ying
    Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston MA, USA.
    Zhou, Chensheng
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.
    Bondi, Arrigo
    Department of Surgical Pathology, Maggiore Hospital, Bologna, Italy.
    Lis, Rosina
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA.
    Van Hemelrijck, Mieke
    Division of Cancer Studies, Translational Oncology, King's College London, London, UK; Urology Research, Guy's Hospital, London, UK.
    Andrén, Ove
    Department of Urology, Örebro University Hospital, Örebro, Sweden; School of Health and Medical Sciences, Örebro University Hospital, Örebro, Sweden.
    Andersson, Sven-Olof
    Department of Urology, Örebro University Hospital, Örebro, Sweden; School of Health and Medical Sciences, Örebro University Hospital, Örebro, Sweden.
    Watson, R. William
    School of Medicine, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD), Dublin, Ireland.
    Pennington, Stephen
    School of Medicine, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
    Finn, Stephen P.
    Department of Histopathology and Morbid Anatomy, School of Medicine, Trinity College Dublin, Dublin, Ireland.
    Martin, Neil E.
    Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA.
    Stampfer, Meir J.
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston MA, USA.
    Parmigiani, Giovanni
    Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston MA, USA.
    Penney, Kathryn L.
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA.
    Fiorentino, Michelangelo
    Department of Pathology, Addarii Institute of Oncology, S.Orsola-Malpighi Teaching Hospital, University of Bologna, Bologna, Italy.
    Mucci, Lorelei A.
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA.
    Loda, Massimo
    Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston MA, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA; The Broad Institute, Cambridge MA, USA.
    Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer2017In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, no 1, article id 420Article in journal (Refereed)
    Abstract [en]

    While progression from normal prostatic epithelium to invasive cancer is driven by molecular alterations, tumor cells and cells in the cancer microenvironment are co-dependent and co-evolve. Few human studies to date have focused on stroma. Here, we performed gene expression profiling of laser capture microdissected normal non-neoplastic prostate epithelial tissue and compared it to non-transformed and neoplastic low-grade and high-grade prostate epithelial tissue from radical prostatectomies, each with its immediately surrounding stroma. Whereas benign epithelium in prostates with and without tumor were similar in gene expression space, stroma away from tumor was significantly different from that in prostates without cancer. A stromal gene signature reflecting bone remodeling and immune-related pathways was upregulated in high compared to low-Gleason grade cases. In validation data, the signature discriminated cases that developed metastasis from those that did not. These data suggest that the microenvironment may influence prostate cancer initiation, maintenance, and metastatic progression.Stromal cells contribute to tumor development but the mechanisms regulating this process are still unclear. Here the authors analyze gene expression profiles in the prostate and show that stromal gene signature changes ahead of the epithelial gene signature as prostate cancer initiates and progresses.

  • 42871.
    Tynngård, N.
    et al.
    Transfusion Medicine, Clinical and Experimental Medicine, Linköpings University, Linköping, Sweden.
    Ramström, Sofia
    Clinical Chemistry, Clinical and Experimental Medicine, Linköpings University, Linköping, Sweden.
    Berlin, G.
    Transfusion Medicine, Clinical and Experimental Medicine, Linköpings University, Linköping, Sweden.
    Adhesion Capacity of Platelets During Storage: Evaluation of a Flow Cytometric Adhesion Assay2012In: Transfusion, ISSN 0041-1132, E-ISSN 1537-2995, Vol. 52, no S3, p. 70A-70AArticle in journal (Refereed)
  • 42872.
    Tynngård, Nahreen
    et al.
    Linköping University, Linköping, Sweden.
    Lindahl, Tomas L.
    Linköping University, Linköping, Sweden.
    Ramström, Sofia
    Linköping University, Linköping, Sweden.
    Assays of different aspects of haemostasis: what do they measure?2015In: Thrombosis Journal, ISSN 1477-9560, E-ISSN 1477-9560, Vol. 13, article id 8Article, review/survey (Refereed)
    Abstract [en]

    Haemostasis is a complex process affected by many factors including both cellular and plasma components. It is a multistep process starting with platelet adhesion to damaged endothelium and ending in clot fibrinolysis. There are several methods available to study different aspects of haemostasis including adhesion, aggregation, coagulation and fibrinolysis. This review describes the different methods, what aspects of haemostasis they measure and their limitations. Methods discussed include methods to study adhesion (e.g. PFA-100, cone and platelet(let) analyzer and perfusion chambers) and aggregation (e.g. Multiplate, VerifyNow and Plateletworks). Furthermore the principles behind viscoelastic haemostatic assays are presented as well as methods that can analyse aspects of haemostasis in plasma or platelet-rich-plasma samples (thrombin generation, overall haemostasis potential and Thrombodynamics Analyzer).

  • 42873.
    Tynngård, Nahreen
    et al.
    Department of Clinical and Experimental Medicine, Division of Transfusion Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden; Department of Clinical Immunology and Transfusion Medicine, County Council of Östergötland, Linköping, Sweden; Department of Clinical Chemistry, County Council of Östergötland, Linköping, Sweden.
    Wallstedt, Maria
    Department of Clinical and Experimental Medicine, Division of Clinical Chemistry, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
    Södergren, Anna L.
    Department of Clinical and Experimental Medicine, Division of Clinical Chemistry, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
    Faxälv, Lars
    Fac Hlth Sci, Dept Clin & Expt Med, Div Clin Chem, Linkoping Univ, Linkoping, Sweden..
    Ramström, Sofia
    Department of Clinical and Experimental Medicine, Division of Clinical Chemistry, Faculty of Health Sciences, Linköping University, Linköping, Sweden; Department of Clinical Chemistry, County Council of Östergötland, Linköping, Sweden.
    Platelet adhesion changes during storage studied with a novel method using flow cytometry and protein-coated beads2015In: Platelets, ISSN 0953-7104, E-ISSN 1369-1635, Vol. 26, no 2, p. 177-185Article in journal (Refereed)
    Abstract [en]

    The aim of the present study was to set up and evaluate a novel method for studies of platelet adhesion and activation in blood and platelet suspensions such as platelet concentrate (PC) samples using protein-coated polystyrene beads and flow cytometry. To demonstrate its usefulness, we studied PCs during storage. PCs were prepared by aphaeresis technique (n = 7). Metabolic variables and platelet function was measured on day 1, 5, 7 and 12 of storage. Spontaneous and TRAP-6-induced adhesion to fibrinogen-and collagen-coated beads was analyzed by flow cytometry. P-selectin and phosphatidyl serine (PS) expression was assessed on platelets bound to beads as well as on non-adherent platelets. Platelet adhesion to fibrinogen beads had increased by day 12 and adhesion to collagen beads at day 7 of storage (p<0.05). TRAP-6 stimulation significantly increased the platelet adhesion to fibrinogen beads (p<0.05) as well as the P-selectin and PS exposure on platelets bound to beads (p<0.01) during the first 7 days of storage, but by day 12, significant changes were no longer induced by TRAP-6 stimulation. We demonstrate that our adhesion assay using protein-coated polystyrene beads can be used to assess the adhesion properties of platelets during storage without the addition of red blood cells. Therefore it may offer a useful tool for future studies of platelet adhesive capacity in transfusion medicine and other settings.

  • 42874.
    Tysk, Andreas
    et al.
    Örebro University, Örebro University School of Business.
    Albildawi, Nour
    Örebro University, Örebro University School of Business.
    Är redovisningsinformation värt mer vid en instabil ekonomi?2013Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
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  • 42875.
    Tysk, Andreas
    et al.
    Örebro University, Örebro University School of Business.
    Andersson, Ulrik
    Örebro University, Örebro University School of Business.
    Immateriella tillgångar - Visa god vilja genom att specificera2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • 42876.
    Tysk, Curt
    Sektionen för Gastroenterologi, Medicinska kliniken, Universitetssjukhuset i Örebro, Örebro, Sverige.
    Ischemisk kolit2012Other (Other academic)
    Abstract [sv]

    Ischemisk kolit är den vanligaste formen av intestinal ischemi. Tillståndet omfattar ett kliniskt spektrum från mild, övergående mukosaischemi (ca 80-85% av fallen) till potentiellt livshotande transmuralt tarmgangrän (ca 15%). Kolon sigmoideum, descendens och vänster flexur är oftast drabbade (75%) medan rektum vanligtvis inte är afficierad. Denna utbredning förklaras av att proximala kolon får sin blodförsörjning via a. mesenterica superior och kolon descendens och sigmoideum via a. mesenterica inferior medan rektum får sin blodförsörjning även via grenar från a. iliaca interna. Området, där de två mesenterialkärlen möts, är hemodynamiskt vulnerabelt med stor variation avseende utvecklade kollateraler. Sjukdomen förekommer framför allt hos äldre personer, men kan ses även hos yngre.

  • 42877.
    Tysk, Curt
    Örebro University, School of Health and Medical Sciences.
    Large intestine: Remission of lymphocytic colitis with budesonide2009In: Nature reviews. Gastroenterology & hepatology, ISSN 1759-5053, Vol. 6, no 9, p. 506-507Article in journal (Refereed)
    Abstract [en]

    Few randomized, controlled trials have investigated the efficacy of pharmacological treatment for lymphocytic colitis. data from a new randomized, placebo-controlled trial have demonstrated the efficacy of budesonide in inducing remission of this disease; this study is an important contribution to this field.

  • 42878.
    Tysk, Curt
    Örebro University, School of Health and Medical Sciences.
    Mikroskopisk kolit2011In: Gastroenterologi och hepatologi / [ed] Rolf Hultcrantz, Annika Bergquist, Stefan Lindgren, Magnus Simrén, Per Stål, Ole B. Suhr, Stockholm: Liber, 2011, p. 315-322Chapter in book (Other academic)
    Abstract [sv]

    Gastroenterologi och hepatologi är den första heltäckande svenska kursboken inom området. Boken ger en helhetssyn på och en samlad kunskap om gastroenterologi och hepatologi. Författarna presenterar pedagogiskt sjukdomarnas patogenes och patofysiologi, hur de yttrar sig kliniskt samt diagnostik och behandling med hjälp av fallbeskrivningar och ett rikt bildmaterial. Boken riktar sig till läkare som genomgår sin specialistutbildning i gastroenterologi och internmedicin i Sverige och Norden, specialister i internmedicin samt vårdpersonal med intresse för området. Boken är även lämplig som referensverk.

  • 42879.
    Tysk, Curt
    et al.
    Örebro University, School of Health and Medical Sciences.
    Almer, Sven
    Andersson, Magnus
    Befrits, Ragnar
    Hertervig, Erik
    Kilander, Anders
    Lindgren, Stefan
    Suhr, Ole
    Nationella riktlinjer för handläggning av akut svårt skov av ulcerös kolit: utarbetat av arbetsgrupp fran SGF och SOIBD2008In: Gastrokuriren, ISSN 1651-0453, Vol. 13, no 3, p. 35-36Article in journal (Other academic)
  • 42880.
    Tysk, Curt
    et al.
    Örebro University, School of Health and Medical Sciences.
    Almer, Sven
    Andersson, Magnus V.
    Befrits, Ragnar
    Hertervig, Erik
    Kilander, Anders
    Lindgren, Stefan
    Suhr, Ole
    Handläggning av svårt skov av ulcerös kolit2009In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 106, no 45, p. 2994-2998Article in journal (Refereed)
    Abstract [sv]

    Patienter med svårt skov av ulcerös kolit bör vårdas på sjukhus och handläggas av gastroenterolog och kolorektal kirurg i nära samarbete.

    Skovets svårighetsgrad kan underskattas, varför noggrann bedömning av inflammationens utbredning och svårighetsgrad enligt validerade kriterier är viktigt.

    Intravenös behandling med kortikosteroider är en av hörn­stenarna i den akuta behandlingen.

    Patienter som inte förbättras på denna behandling, bör erbjudas medicinsk »rescue-behandling« eller kolektomi.

    Infliximab har visats vara en effektiv rescue-behandling och kan minska behovet av kol­ektomi inom de första 3 månaderna och upp till 3 år. 

  • 42881.
    Tysk, Curt
    et al.
    Örebro University, School of Health and Medical Sciences.
    Bohr, Johan
    Nyhlin, Nils
    Wickbom, Anna
    Eriksson, Sune
    Diagnosis and management of microscopic colitis2008In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 14, no 48, p. 7280-7288Article in journal (Other academic)
    Abstract [en]

    Microscopic colitis, comprising collagenous and lymphocytic colitis, is characterized clinically by chronic watery diarrhea, and a macroscopically normal colonic mucosa where diagnostic histopathological features are seen on microscopic examination. The annual incidence of each disorder is 4-6/100,000 inhabitants, with a peak incidence in 60-70-year-old individuals and a noticeable female predominance for collagenous colitis. The etiology is unknown. Chronic diarrhea, abdominal pain, weight loss, fatigue and fecal incontinence are common symptoms, which impair the health-related quality of life of the patient. There is an association with other autoimmune disorders such as celiac disease, diabetes mellitus, thyroid disorders and arthritis. Budesonide is the best-documented short-term treatment, but the optimal long-term strategy needs further study. The long-term prognosis is good and the risk of complications including colonic cancer is low.

  • 42882.
    Tysk, Curt
    et al.
    Örebro University, School of Health and Medical Sciences.
    Wickbom, Anna
    Nyhlin, Nils
    Eriksson, Sune
    Bohr, Johan
    Recent advances in diagnosis and treatment of microscopic colitis2011In: Annals of Gastroenterology, ISSN 1108-7471, E-ISSN 1792-7463, Vol. 24, no 4, p. 253-262Article in journal (Other academic)
    Abstract [en]

    Microscopic colitis, comprising collagenous colitis and lymphocytic colitis, is a common cause of chronic diarrhoea. It is characterised clinically by chronic watery diarrhoea and a macroscopically normal colonic mucosa where diagnostic histopathological features are seen on microscopic examination. The annual incidence of each disorder is 4-6/100000 inhabitants, with a peak incidence in individuals 60-70 years old and a noticeable female predominance in collagenous colitis. The aetiology is unknown. Chronic diarrhoea, abdominal pain, weight loss, fatigue, and faecal incontinence are common symptoms that impair the health-related quality of life of the patient. There is an association with other autoimmune disorders, such as celiac disease, thyroid disorders, diabetes mellitus, and arthritis. Budesonide is the best-documented treatment, both short-term and long-term. Recurrence of symptoms is common after withdrawal of successful budesonide therapy, and the optimal long-term treatment strategy needs further study. The long-term prognosis is good, and the risk of complications including colonic cancer is low. We review epidemiology, clinical features, diagnosis and treatment of microscopic colitis,

  • 42883.
    Tyynismaa, Henna
    et al.
    Research Program of Molecular Neurology, Biomedicum-Helsinki, Helsinki, Finland.
    Carroll, Christopher J.
    Research Program of Molecular Neurology, Biomedicum-Helsinki, Helsinki, Finland.
    Raimundo, Nuno
    Research Program of Molecular Neurology, Biomedicum-Helsinki, Helsinki, Finland.
    Ahola-Erkkilä, Sofia
    Research Program of Molecular Neurology, Biomedicum-Helsinki, Helsinki, Finland.
    Wenz, Tina
    Department of Neurology and Cell Biology and Anatomy, University of Miami, Miller School of Medicine, Miami, USA.
    Ruhanen, Heini
    Research Program of Molecular Neurology, Biomedicum-Helsinki, Helsinki, Finland.
    Guse, Kilian
    Molecular Cancer Biology Program & Transplantation Laboratory, Haartman Institute & Finnish Institute for Molecular Medicine & HUSLAB & Helsinki University Central Hospital, Cancer Gene Therapy Group, Helsinki, Finland.
    Hemminki, Akseli
    Molecular Cancer Biology Program & Transplantation Laboratory, Haartman Institute & Finnish Institute for Molecular Medicine & HUSLAB & Helsinki University Central Hospital, Cancer Gene Therapy Group, Helsinki, Finland.
    Peltola-Mjøsund, Katja E.
    Research Program of Molecular Neurology, Biomedicum-Helsinki, Helsinki, Finland.
    Tulkki, Valtteri
    Research Program of Molecular Neurology, Biomedicum-Helsinki, Helsinki, Finland.
    Oresic, Matej
    Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland; VTT Technical Research Centre of Finland, Espoo, VTT, Finland.
    Moraes, Carlos T.
    Department of Neurology and Cell Biology and Anatomy, University of Miami, Miller School of Medicine, Miami, FL, USA.
    Pietiläinen, Kirsi
    Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.
    Hovatta, Iiris
    Research Program of Molecular Neurology, Biomedicum-Helsinki, Helsinki, Finland; Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare and Department of Medical Genetics, University of Helsinki, Helsinki, Finland.
    Suomalainen, Anu
    Research Program of Molecular Neurology, Biomedicum-Helsinki, Helsinki, Finland; Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland; Department of Neurology, Helsinki, University Central Hospital, Helsinki, Finland.
    Mitochondrial myopathy induces a starvation-like response2010In: Human Molecular Genetics, ISSN 0964-6906, E-ISSN 1460-2083, Vol. 19, no 20, p. 3948-3958Article in journal (Refereed)
    Abstract [en]

    Mitochondrial respiratory chain (RC) deficiency is among the most common causes of inherited metabolic disease, but its physiological consequences are poorly characterized. We studied the skeletal muscle gene expression profiles of mice with late-onset mitochondrial myopathy. These animals express a dominant patient mutation in the mitochondrial replicative helicase Twinkle, leading to accumulation of multiple mtDNA deletions and progressive subtle RC deficiency in the skeletal muscle. The global gene expression pattern of the mouse skeletal muscle showed induction of pathways involved in amino acid starvation response and activation of Akt signaling. Furthermore, the muscle showed induction of a fasting-related hormone, fibroblast growth factor 21 (Fgf21). This secreted regulator of lipid metabolism was also elevated in the mouse serum, and the animals showed widespread changes in their lipid metabolism: small adipocyte size, low fat content in the liver and resistance to high-fat diet. We propose that RC deficiency induces a mitochondrial stress response, with local and global changes mimicking starvation, in a normal nutritional state. These results may have important implications for understanding the metabolic consequences of mitochondrial myopathies.

  • 42884.
    Tägil, Ingela
    Örebro University, School of Music, Theatre and Art.
    Jenny Lind: röstens betydelse för hennes mediala identitet, en studie av hennes konstnärsskap 1838-492013Doctoral thesis, monograph (Other academic)
    Abstract [en]

    Jenny Lind was an opera singer in the years 1838–49. During this time she was given the status f an icon mainly due to her image. She was almost sanctified by the press. Her “private personality” was assigned a saintly purity, and she became a stereotype symbol of femininity. This dissertation investigates what factors interacted that made this possible, and highlight the importance of Lind’s voice for her image. Jenny Lind’s voice was a high soprano, but not very powerful. By positioning herself in a singing tradition that corresponded to her voice’s advantages, she managed to develop an equilibrium, which she used well. Lind’s voice was often perceived as unusual; she had a particular voice timbre. She also had a vocal defect. Her tones from f’–a’ are described as “husky”, and sometimes hoarse. This means that her voice let through more air than her vocal cords could use. My argument is that it was the voice damage that created unique timbre that the contemporary critics perceived as particularly “feminine”. Lind’s weak and damaged voice corresponds to the nineteenth century’s female ideal: fragile and weak. Moreover, Lind needed to adept her roles to her damage voice and the consequence was that also her interpretations were perceived “feminine”. In other words, Lind exerted a gender performative voice processing. All of Jenny Lind’s roles became representatives of femininity, regardless of whether it was the role’s purpose or not. Lind adapted all her interpretations to her weak voce, it's strength being high notes, pianissimo dynamics and equilibrism, and gave all her roles a genderstereotyped voice.

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  • 42885.
    Tägil, Ingela
    Örebro University, School of Music, Theatre and Art.
    Jenny Lind's vocal strain2012In: Opera on the move in the Nordic countries during the long 19th century / [ed] Anne Sivuoja, Owe Ander, Ulla-Britta Broman-Kananen, Jens Hesselager, Helsinki: Sibelius Academy, 2012, p. 83-92Chapter in book (Refereed)
  • 42886.
    Tägil, Magnus
    et al.
    Skåne University Hospital/SUS, Malmö/Lund, Sweden.
    Berne, Hanna
    Skåne University Hospital/SUS, Malmö/Lund, Sweden.
    Geijer, Mats
    Örebro University, School of Medical Sciences. Örebro University Hospital.
    Kopylov, Philippe
    Skåne University Hospital/SUS, Malmö/Lund, Sweden.
    Abramo, Antonio
    Skåne University Hospital/SUS, Malmö/Lund, Sweden.
    Primary hemi-prosthetic replacement of the distal radio-ulnar joint (DRUJ) in 12 rheumatoid patients after minimum 5 year.: A clinical report and a radiographic analysis focusing on periimplant bone remodeling2017Conference paper (Refereed)
  • 42887.
    Tägt, Daniel
    et al.
    Örebro University, Örebro University School of Business.
    Wijnbladh, Erik
    Örebro University, Örebro University School of Business.
    Informationssäkerhet inom Internet of Things, vad finns det för behov av en standard?: En kvalitativ studie om utvecklarnas syn på behovet av en standard inom Internet of Things2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • 42888.
    Tähtinen, Marie
    Örebro University, School of Science and Technology.
    Migration av östrogenlika ämnen från förpackningsmaterial till livsmedel2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Förpackningsmaterial av plast är idag vida använt inom livsmedelsindustrin för att skydda livsmedel under transport, förvaring och tillagning. Vid tillverkning av plast används ett flertal olika additiv som visat sig kunna migrera till livsmedel och verka hormonstörande. Migrationen av ämnen från förpackningsmaterial påverkas av flera parametrar så som temperatur, förvaringstid, livsmedlets egenskaper som till exempel fetthalt eller aciditet samt det migrerade ämnenas egenskaper. Syftet med studien var att undersöka förekomst av östrogenlika ämnen i ett vanligt förekommande förpackningsmaterialet (TPH100) som används vid förvaring och uppvärmning samt om dessa ämnen migrerar till livsmedel under olika förhållanden. I Studien användes två livsmedelssimulanter, ättiksyra 3% (B) samt etanol 50% (D1) specificerade i gällande direktiv inom Europa. Temperaturens påverkan på migration från förpackningsmaterialet till livsmedelssimulantlösningarna undersöktes genom kylskåpsförvaring samt kylskåpsförvaring med efterföljande uppvärmning i ugn. Förekomst av östrogenlika ämnen i materialet och livsmedelssimulantlösningar analyserades med en mekanismspecifik östrogenreceptor (ER)-baserad bioanalys U2OS-ERα CALUX. För att undersöka om den östrogenlika aktiviteten som uppmättes i materialet kom från PAHer analyserades provet även med en aryl hydrocarbon (Ah)-receptor baserad bioanalys HII4E-luc.

    Studiens resultat visade förekomst av ämnen i förpackningsmaterialet som kunde binda till och aktivera östrogenreceptor ERα (4.1 pg EEQ/g plast). Vidare indikerade resultaten att dessa ämnen kan migrera till livsmedel med likvärdig aciditet som livsmedelssimulant B (< pH 4,5) vid upphettning till 121 Cº i ugn under en timme. Migrationen från materialet under dessa förhållanden var 1,1-2,0 pg EEQ/g. För livsmedelssimulant B uppmättes ingen kvantifierbar migration vid kylskåpsförvaring. Resultaten för livsmedelssimulant D1 vid kylskåpsförvaring och/eller uppvärmning visade att det inte förekom någon migration till livsmedel med hög fetthalt i kvantifierbara mängder. Ingen kvantifierbar Ah-receptor aktivitet kunde detekteras med HII4E-luc bioanalysen vilket visar att det troligen inte var PAHer som orsakade den östrogenlika effekten. Resultaten indikerar att materialet innehåller och kan avge kvantifierbara mängder östrogenlika ämnen till livsmedel vid användning. Vidare studier med kemiskanalys behövs för att identifiera vilka ämnen som orsakat effekten i bioanalysen.

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  • 42889.
    Täng Nilsson, Helen
    Örebro University, School of Law, Psychology and Social Work.
    Det fjärde tillägget till den amerikanska konstitutionen v. Rättegångsbalken: Husrannsakan, beslag och bevisregler2012Independent thesis Basic level (degree of Bachelor), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Uppsatsens syfte är att med hjälp av den juridiska och komparativa metoden utreda tvångsmedlen husrannsakan och beslag samt bevisregler inom svensk respektive amerikansk rätt. Det ska utredas vad som avses med husrannsakan och beslag, när en sådan åtgärd får beslutas om och vem som beslutar om dem. De gällande bevisreglerna i respektive land ska även utredas, med fokus på bevisföringen.

     

    I Sverige finns möjligheten att använda straffprocessuella tvångsmedel reglerade i RB. För att få till stånd en reell eller personell husrannsakan krävs att det förekommer anledning anta att ett brott har begåtts, på vilket fängelse kan följa och att det finns en person som är skäligen misstänkt för brottet. Det är förundersökningsledaren, åklagare, polis och rätten som kan besluta om det. Tvångsmedlet beslag används för att beslagta föremål som antas äga betydelse för utredning om brott, vara genom brott någon avhänt eller på grund av brott förverkat. För att föremål ska kunna beslagtas krävs dels att ett brott har begåtts och dels att det skäligen kan antas att det finns ett samband mellan det brottet och någon av de tre grunderna för beslag. Det krävs inte att någon är skäligen misstänkt för ett brott eller att brottet som begåtts ska vara av viss svårighetsgrad. Rätten, åklagaren och polisen har möjlighet att besluta om beslag.

     

    I USA regleras husrannsakan och beslag i samma paragraf, i det fjärde tillägget till landets konstitution, som reglerar searches and seizures. I paragrafen stadgas att oskäliga former av husrannsakan och beslag är olagliga och för att avgöra om en åtgärd strider mot paragraf genomförs en bedömning i flera steg. Det finns ett flertal undantag till huvudregeln om att det måste finnas ett giltigt beslut. Om något har funnits och beslagtagits i strid med fjärde tillägget får det till följd att eventuella bevis inte får åberopas vid en rättegång. Denna regel kallas exclusionary rule och är en amerikansk bevisregel om bevisföring. Det finns fyra huvudsakliga undantag från regeln som innebär att bevis ändå kan åberopas i en rättegång.

     

    Enligt RB gäller fri bevisföring vilket innebär att i princip alla bevismedel är tillåtna. I flera svenska rättsfall har det fastslagits att även om ett bevis uppkommit på ett lagstridigt sätt kan det åberopas i rättegången och ges ett högt bevisvärde. Europadomstolen har vid ett flertal gånger dömt att den nationella domstolen brutit mot art 6 EKMR när den tillåtit bevis som tillkommit på ett olagligt sätt, men har också friat vid andra tillfällen.

     

    De huvudsakliga slutsatser som kan dras är att det föreligger stora skillnader mellan de två länderna om vem och hur beslutet tas om husrannsakan och beslag. I USA är huvudregeln att en domare ska besluta om husrannsakan och beslag medan det i Sverige är domare eller åklagare. Inom reglerna om bevisföring finns också stora skillnader då det i Sverige råder en fri bevisföring, medan bevis som tillkommit på ett olagligt sätt inte kan åberopas i en rättegång i USA. Reglering kring detta är enligt mig önskvärt i Sverige.

     

  • 42890.
    Täng Nilsson, Helen
    Örebro University, School of Law, Psychology and Social Work.
    Plea bargaining i USA: - något för Sverige?2010Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 42891.
    Tärnmark, Karolina
    Örebro University, School of Medical Sciences.
    Fall related visits to the emergency department, among elderly: - Are there areas for improvement?2016Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • 42892.
    Tärnmark, Karolina
    Örebro University, School of Medicine, Örebro University, Sweden.
    Prevalence of diagnosed dementia in subjects with schizophrenia as compared to the general population.2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Download full text (pdf)
    Prevalence of diagnosed dementia in subjects with schizophrenia as compared to the general population.
  • 42893.
    Tålsgård, Marina
    et al.
    Örebro University, Department of Education.
    Larsson, Ann-sofie
    Örebro University, Department of Education.
    Bergvall, Hanna
    Örebro University, Department of Education.
    Frågans betydelse för elevernas lärande och för deras motivation2006Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Vi har valt att skriva om motivation och frågans roll i klassrummet. I denna uppsats utgår vi från ett sociokulturellt perspektiv samt redogör för motivation och några av dess olika teorier. Vårt syfte med vår uppsats är att studera motivation och vilken roll frågan,sättet att ställa frågor, spelar för undervisningen och för lärande. Genom att intervjua elever i år 4-6 och använda oss av exemplet frågans roll i ämnet geografi vill vi ta reda på om den goda frågan existerar, samt ta reda på hur/om eleverna själva känner sig motiverad i skolan. I vår diskussion resonerar vi om hur elevernas motivation att lära kan förstås utifrån de olika motivationsteorierna samt resonera om hur lärarens sätt att använda sig av olika typer av frågor får betydelse för elevernas sätt att lära.

  • 42894.
    Tångdahl, Sara
    Örebro University, Swedish Business School at Örebro University.
    Nonresponse bias for some common estimators and its change over time in the data collection process2004Report (Other academic)
    Abstract [en]

    In most surveys, the risk of nonresponse is a factor taken into account at the planning stage. Commonly, resources are set aside for a follow-up procedure which aims at reducing the nonresponse rate. However, we should pay attention to the effect of nonresponse, rather than the nonresponse rate itself.

    When considering nonresponse error, i.e. bias and variance, it is not obvious that the resources spent on nonresponse rate reduction efforts are time and money well spent. In this paper we address this issue, focusing on the effect of follow-ups on nonresponse bias. The nonresponse biases for some common estimators are derived, and the change in bias for these estimators is studied under a setup that allows us to take into account the data collection process, and follow-up efforts in particular.

  • 42895.
    Tångdahl, Sara
    Örebro University, Swedish Business School at Örebro University.
    On the evaluation of the cost efficiency of nonresponse rate reduction efforts: some general considerations2006Report (Other academic)
    Abstract [en]

    Virtually every survey today suffers from nonresponse to some extent. To counter this, survey administrators and researchers have a host of methods at their disposal, many of which are both expensive and time consuming. Reduction efforts, aiming at reducing the nonresponse rate, are an important part of the data collection process, but commonly also a substantial part of the available survey budget.

    We propose that the effciency of the reduction efforts be evaluated in relation to the costs. In this paper we point in the direction of an evaluation procedure, using a measure of cost effciency, that can be used in an "ideal" situation, where all relevant quantities are known. It can not be applied directly in practice, but will serve as a point of reference when practically feasible approaches are developed.

  • 42896.
    Tångdahl, Sara
    Örebro University, Swedish Business School at Örebro University.
    The variance of some common estimators and its components under nonresponse2005Report (Other academic)
    Abstract [en]

    In most surveys, the risk of nonresponse is a factor taken into account at the planning stage. Commonly, resources are set aside for a follow-up procedure which aims at reducing the nonresponse rate. However, we should pay attention to the effect of nonresponse, rather than the nonresponse rate itself. When considering nonresponse error, i.e. bias and variance, it is not obvious that the resources spent on nonresponse rate reduction efforts are time and money well spent.

    In this paper we address this issue, continuing the work begun in Tångdahl (2004), now focusing on the effect of follow-ups on estimator variance. The components of the variance for some common estimators are derived under a setup that allows us to take into account the data collection process, and follow-up efforts in particular.

  • 42897.
    Tönnberg, Cecilia
    Örebro University, School of Humanities, Education and Social Sciences.
    Analys av läromedel i svenska2014Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Download full text (pdf)
    fulltext
  • 42898.
    Tönnberg, Cecilia
    Örebro University, School of Humanities, Education and Social Sciences.
    Gulliga tanter och argsinta gubbar: - om genus i tre av Astrid Lindgrens verk2015Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Download full text (pdf)
    fulltext
  • 42899.
    Tönnäng, Erik
    et al.
    Örebro University, Department of Business, Economics, Statistics and Informatics.
    Lindegren, Jonas
    Örebro University, Department of Business, Economics, Statistics and Informatics.
    Ekonomistyrning i Hyresgästföreningen: -en kvalitativ fallstudie2006Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    I takt med ökad globalisering och den teknologiska utvecklingen blir klimatet för organisationer allt mer instabilt och föränderligt. Det är därför viktigt att kunna styra organisationen genom att fatta snabba beslut. På grund av detta krävs en ekonomistyrning som inkluderar många viktiga delar för beslutsfattarna.

    Det har gjorts många studier om ekonomistyrning för vinstdrivande företag, men studier som behandlar den ideella sektorn är mer sällsynta. Därför har vi valt att studera ekonomistyrningen i en ideell organisation, Hyresgästföreningen. De slutsatser som dragits i studien kan jämföras med liknande organisationer, dock kan slutsatserna inte ses som allmängiltiga.

    Syftet med studien är att öka förståelsen för ekonomistyrning i ideella organisationer genom att undersöka vilka styrmedel Hyresgästföreningen använder sig av. Vidare är syftet att identifiera hur dessa styrmedel används samt att analysera, utifrån institutionell teori och struktureringsteori, varför Hyresgästföreningen använder sina styrmedel på det sättet de gör.

    För att besvara frågeställningarna har institutionell teori och struktureringsteori presenterats, vilka sedan ligger till grund för den avslutande analysen. Studien tar även upp vanliga styrmedel, så som kalkyler/budgetar, belöningssystem, balanserat styrkort och externredovisning. För att få en uppfattning om hur dessa delar används i Hyresgästföreningen har två telefonintervjuer genomförts. Den förta var med Urban Ehrenborg, som är ekonomichefen för Hyresgästföreningen, den andra med ekonomicontrollern Christian Rickardsson.

    De viktigaste slutsatser vi dragit är att Hyresgästföreningen använder sig till stor del av det balanserade styrkortet och budgetar. Det balanserade styrkortet används till stor del för att mäta hur medlemmar förhåller sig till Hyresgästföreningen men även andra delar, så som allmänhetens uppfattning. Utifrån dessa mätningar sätts sedan mål upp som föreningen strävar efter att uppfylla. Anledningen till varför föreningen använder sina styrmedel på det sätt de gör har sin grund i att de ska generera medlemsnytta. Skapas inte medlemsnytta finns det ingen anledning att medlemmarna stannar i föreningen.

    Download full text (pdf)
    FULLTEXT01
  • 42900. Törkvist, Leif
    et al.
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Ong, Rick T H
    Lördal, Mikael
    Sjöqvist, Urban
    Bresso, Francesca
    Björk, Jan
    Befrits, Ragnar
    Löfberg, Robert
    Blom, Johannes
    Carlson, Marie
    Padyukov, Leonid
    D'Amato, Mauro
    Seielstad, Mark
    Pettersson, Sven
    Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients2010In: Inflammatory Bowel Diseases, ISSN 1078-0998, E-ISSN 1536-4844, Vol. 16, no 6, p. 907-909Article in journal (Refereed)
855856857858859860861 42851 - 42900 of 47073
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