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  • 51. Ruiz, Jonatan R.
    et al.
    Hurtig-Wennlöf, Anita
    Örebro universitet, Institutionen för klinisk medicin.
    Ortega, Francisco B.
    Patterson, Emma
    Nilsson, Torbjörn K.
    Örebro universitet, Institutionen för klinisk medicin.
    Castillo, Manuel J.
    Sjöström, Michael
    Homocysteine levels in children and adolescents are associated with the methylenetetrahydrofolate reductase 677C>T genotype, but not with physical activity, fitness or fatness: the European Youth Heart Study2007Inngår i: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 97, nr 2, s. 255-262Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    To examine the associations of total plasma homocysteine (tHcy) with physical activity, cardiorespiratory fitness and fatness in children and adolescents, a cross-sectional study of 301 children (9–10 years old) and 379 adolescents (15–16 years old) was conducted. Physical activity was measured by accelerometry. Cardiorespiratory fitness was measured with a maximal ergometer bike test. Body fat was derived from the sum of five skinfold thicknesses. Genotyping for the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism was done by DNA sequencing. Fasting tHcy level was the outcome variable. Multiple regressions were used to determine the degree to which variance in tHcy was explained by physical activity, cardiorespiratory fitness and body fat, after controlling for potential confounders including MTHFR 677C>T genotype. tHcy levels were neither associated with any measure of level and pattern of physical activity nor with data on cardiorespiratory fitness, or body fat, in any age group after controlling for potential confounders including MTHFR 677C>T and even when subgroups 677TT and 677CC+CT were analysed separately. Mean values of tHcy were significantly higher in the TT subgroup compared with CC and CT subgroups in children (TT 7·4 μmol/l, CC 6·3 μmol/l, CT 6·6 μmol/l, P < 0·001 and P = 0·019, respectively) and adolescents (TT 16·9 μmol/l, CC 8·3 μmol/l, CT 9·0 μmol/l, both P < 0·001). The results suggest that physical activity, fitness and body fat are not associated with tHcy levels in children and adolescents, even after controlling for presence of the MTHFR 677C>T genotype, the main influence on tHcy levels in these subjects.

  • 52. Ruiz, Jonatan R.
    et al.
    Ortega, Francisco B.
    Rizzo, Nico S.
    Villa, Inga
    Hurtig-Wennlöf, Anita
    Örebro universitet, Institutionen för klinisk medicin.
    Oja, Leila
    Sjöström, Michael
    High cardiovascular fitness is associated with low metabolic risk score in children: the European Youth Heart Study2007Inngår i: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 61, nr 3, s. 350-355Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of the present study was to examine the associations of cardiovascular fitness (CVF) with a clustering of metabolic risk factors in children, and to examine whether there is a CVF level associated with a low metabolic risk. CVF was estimated by a maximal ergometer bike test on 873 randomly selected children from Sweden and Estonia. Additional measured outcomes included fasting insulin, glucose, triglycerides, HDLC, blood pressure, and the sum of five skinfolds. A metabolic risk score was computed as the mean of the standardized outcomes scores. A risk score <75th percentile was considered to indicate a low metabolic risk. CVF was negatively associated with clustering of metabolic risk factors in children. Receiver operating characteristic curve analysis showed a significant discriminatory accuracy of CVF in identifying the low/high metabolic risk in girls and boys (p < 0.001). The CVF level for a low metabolic risk was 37.0 and 42.1 mL/kg/min in girls and boys, respectively. These levels are similar to the health-related threshold values of CVF suggested by worldwide recognized organizations. In conclusion, the results suggest a hypothetical CVF level for having a low metabolic risk, which should be further tested in longitudinal and/or intervention studies. Abbreviations: AUC, area under the curve CVF, cardiovascular fitness ROC, receiver operating characteristic

  • 53. Ruiz, Jonatan R.
    et al.
    Rizzo, Nico S.
    Hurtig-Wennlöf, Anita
    Örebro universitet, Institutionen för klinisk medicin.
    Ortega, Francisco B.
    Wärnberg, Julia
    Sjöström, Michael
    Relations of total physical activity and intensity to fitness and fatness in children: the European Youth Heart Study2006Inngår i: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 84, nr 2, s. 299-303Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: It is unclear how the amount and intensity of physical activity (PA) are associated with cardiovascular fitness (CVF) and body fatness in children.

    Objective: We aimed to examine the associations of total PA and intensity levels to CVF and fatness in children.

    Design: A cross-sectional study of 780 children aged 9–10 y from Sweden and Estonia was conducted. PA was measured by accelerometry and was expressed as min/d of total PA, moderate PA, and vigorous PA. CVF was measured with a maximal ergometer bike test and was expressed as W/kg. Body fat was derived from the sum of 5 skinfold-thickness measurements. Multiple regression analysis was used to determine the degree to which variance in CVF and body fat was explained by PA, after control for age, sex, and study location.

    Results: Lower body fat was significantly associated with higher levels of vigorous PA, but not with moderate or total PA. Those children who engaged in >40 min vigorous PA/d had lower body fat than did those who engaged in 10–18 min vigorous PA/d. Total PA, moderate PA, and vigorous PA were positively associated with CVF. Those children who engaged in >40 min vigorous PA/d had higher CVF than did those who accumulated <18 min vigorous PA/d.

    Conclusions: The results suggest that PA of vigorous intensity may have a greater effect on preventing obesity in children than does PA of lower intensity, whereas both total and at least moderate to vigorous PA may improve children's CVF.

  • 54. Sjöström, Michael
    et al.
    Yngve, Agneta
    Poortvliet, Eric
    Ekelund, Ulf
    Örebro universitet, Hälsoakademin.
    Hurtig-Wennlöf, Anita
    Örebro universitet, Institutionen för klinisk medicin.
    Nilsson, Andreas
    Hagströmer, Maria
    Adolescent nutrition: a multidimensional challenge2003Inngår i: Modern aspects of nutrition: present knowledge and future perspectives / [ed] I. Elmadfa, E. Anklam, J. König, 2003, Vol. 56, s. 253-254Konferansepaper (Fagfellevurdert)
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