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  • 651.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Multisjuklighet hos äldre: analys, handläggning och förslag om äldrevårdscentral2004 (ed. 1)Book (Other (popular science, discussion, etc.))
  • 652.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Multisjuklighet hos äldre personer2012In: Äldres hälsa: ett sjukgymnastiskt perspektiv / [ed] Elisabeth Rydwik, Lund: Studentlitteratur AB, 2012, 1, p. 367-382Chapter in book (Other academic)
  • 653.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Mår de allra äldsta verkligen sämre idag? [Is the health of the elderly really worse nowadays?]: medicinsk kommentar2004In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 101, no 17, p. 1470-1471Article in journal (Other academic)
  • 654.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Nutrition och fysisk funktion/fysisk aktivitet hos äldre personer: En sammanställning av kunskapsläget och aktuella kunskapsbehov2009Report (Other academic)
  • 655.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Orsaker till mat- och nutritionsproblem inom äldrevården samt förslag till utveckling och förbättringsarbete2006In: Nordisk Geriatrik, no 4, p. 36-41Article in journal (Other academic)
  • 656.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    PEG treatment: an increasing dilemma2005In: Age and Ageing, ISSN 0002-0729, E-ISSN 1468-2834, Vol. 34, no 4, p. 320-321Article in journal (Refereed)
  • 657.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Psykogeriatrik bör bli specialitet [Psychogeriatrics should be a specialty]: medicinsk kommentar2009In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 106, no 1-2, p. 19-19Article in journal (Other academic)
  • 658.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Sammanfattning2003In: Evidensbaserad äldrevård: en inventering av det vetenskapliga underlaget / [ed] Gunnar Akner, Stockholm: Statens beredning för medicinsk utvärdering (SBU) , 2003, 1, p. 9-24Chapter in book (Other academic)
  • 659.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Sex perspektiv på multisjuklighet och multibehandling hos äldre [Six perspectives on comorbidity and multiple treatments among the elderly: hur vet vi om vidtagna behandlingsåtgärder är effektiva? : debatt [How do we know that the taken therapeutic measures are efficient?]2002In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 99, no 40, p. 3972-3973Article in journal (Other academic)
  • 660.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Sjukvården försummar att vara en lärande organisation2014In: Sjukhusläkaren, ISSN 1651-2715, no 2, p. 25-Article in journal (Other (popular science, discussion, etc.))
  • 661.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Stort behov av generalistorienterad analysstödjande hälsoinformation [Big need of generalist-oriented analysis-supporting health information]2007In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 104, no 34, p. 2356-2358Article in journal (Other academic)
  • 662.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Strukturformler behövs i Fass! [Structural formulas are necessary in Fass]1993In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 90, no 38, p. 3179-3180Article in journal (Other (popular science, discussion, etc.))
  • 663.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Summary2003In: Geriatric care and treatment: a systematic compilation of existing scientific literature / [ed] Gunnar Akner, Stockholm: Statens beredning för medicinsk utvärdering (SBU) , 2003, 1, p. 9-22Chapter in book (Other academic)
  • 664.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    SWOT-analys av geriatriken i Sverige2006In: Nordisk Geriatrik, no 2, p. 42-43Article in journal (Other academic)
  • 665.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    The ethics of ignorance1995In: Journal of Medical Ethics, ISSN 0306-6800, E-ISSN 1473-4257, Vol. 21, no 1, p. 56-56Article in journal (Refereed)
  • 666.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Tid för klinisk analys2015In: Sjukhusläkaren, ISSN 1651-2715, no 1, p. 34-34Article in journal (Other (popular science, discussion, etc.))
  • 667.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Undernutritionstillstånd vid KOL2014In: KOL: Kroniskt obstruktiv lungsjukdom / [ed] Kjell Larsson, Stockholm: Studentlitteratur AB, 2014, 3, p. 497-508Chapter in book (Other academic)
  • 668.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Undernäringstillstånd2003In: Evidensbaserad äldrevård: en inventering av det vetenskapliga underlaget / [ed] Gunnar Akner, Stockholm: Statens beredning för medicinsk utvärdering (SBU) , 2003, 1, p. 257-264Chapter in book (Other academic)
  • 669.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Undernäringstillstånd vid KOL2006In: KOL: kroniskt obstruktiv lungsjukdom / [ed] Kjell Larsson, Stockholm: Studentlitteratur , 2006, 2, p. 227-237Chapter in book (Other academic)
  • 670.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Varför är just 30 specialiteter det ideala? [Why are just 30 specialists the ideal number?]1998In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 95, no 4, p. 257-257Article in journal (Other (popular science, discussion, etc.))
  • 671.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Vilka evidens finns och används för dagens styrning av äldrevården?2014In: Sjukhusläkaren, ISSN 1651-2715, no 4, p. 34-34Article in journal (Other (popular science, discussion, etc.))
  • 672.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Visualization of evaluation and management of the 'nutrition process' in individual elderly, multimorbid patients2010In: The Journal of Nutrition, Health & Aging, ISSN 1279-7707, E-ISSN 1760-4788, Vol. 14, no 6, p. 502-502Article in journal (Refereed)
  • 673.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences.
    Äldrevård måste grundas på etik [Health services for the aged must be based on ethical foundations]: den enskilde patientens bästa skall alltid stå i fokus : medicinsk kommentar [Focused on the best for the individual patient]2006In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 103, no 41, p. 3068-3069Article in journal (Other (popular science, discussion, etc.))
  • 674.
    Akner, Gunnar
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Äldrevården måste bli mer proaktiv och personinriktad2014In: Sjukhusläkaren, ISSN 1651-2715, no 6, p. 17-17Article in journal (Other (popular science, discussion, etc.))
  • 675.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Andersson, H.
    Forsum, E:
    Hallmans, G.
    Thesleff, P.
    Vessby, B.
    Nutritionsrelaterade moment under läkarutbildningen vid KI [A national document on clinical nutrition. Developmental work for improvement of medical education]1997In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 94, no 18, p. 1731-1734, 1739Article in journal (Other academic)
  • 676.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Asp, Nils-Georg
    Forsum, Elisabet
    Hådell, Karin
    Laser Reuterswärd, Anita
    Wersäll, Jan
    Näringsläran syns inte i läkarutbildningen [Nutrition is not visible in medical educations]1995In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 92, no 46, p. 4347-4348Article in journal (Other academic)
  • 677.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Berglund, Johan
    Dehlin, Ove
    Montnémery, Peter
    Rundgren, Åke
    von Zur-Mühlen, Bengt
     Stort behov av ny generalistläkare - förslag till övergripande verksamhet [Great need of generalists--proposal of an overall activity]2008In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 105, no 8, p. 551-552Article in journal (Other academic)
  • 678.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Boréus, Lars
    Drug treatment2003In: Geriatric care and treatment: a systematic compilation of existing scientific literature / [ed] Gunnar Akner, Stockholm: Statens beredning för medicinsk utvärdering (SBU) , 2003, 1, p. 233-256Chapter in book (Other academic)
  • 679.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Boréus, Lars
    Läkemedelsbehandling2003In: Evidensbaserad äldrevård: en inventering av det vetenskapliga underlaget / [ed] Gunnar Akner, Stockholm: SBU , 2003, 1, p. 233-256Chapter in book (Other academic)
  • 680.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Bosaeus, I.
    Forsum, E.
    Thesleff, P.
    Diagnostiskt prov i klinisk nutrition för läkarstuderande [Diagnostic test in clinical nutrition for medical students]: provresultat visar att utbildningen i klinisk nutrition måste förbättras [Test results show that training in clinical nutrition must be improved]2001In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 98, no 21, p. 2604-6, 2609-2610Article in journal (Refereed)
    Abstract [sv]

    A national core curriculum in clinical nutrition was approved by the Section for Nutrition in the Swedish Society of Medicine in 1995. Here we report on the results of an anonymous diagnostic test based on this core curriculum in clinical nutrition, administered to medical students at the end of medical school. The test was the same for students in Linköping, Lund and Stockholm. Only 42% of the participants obtained an acceptable test result, with the score in Lund being significantly lower than those in Linköping and Stockholm. We compare the results with a similar test administered in Stockholm in 1996, and discuss current developmental work in clinical nutrition being done in all the medical faculties in Sweden.

  • 681.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Bosaeus, Ingvar
    Avd. för klinisk näringslära, Göteborgs universitet, Göteborg, Sverige.
    Cederholm, Tommy
    Klinisk nutrition och metabolism och Inst. för folkhälso- och vårdvetenskap, Uppsala universitet, Uppsala, Sverige.
    Rothenberg, Elisabet
    Avd. för klinisk näringslära, Göteborgs universitet, Göteborg, Sverige.
    Ödlund Olin, Ann
    Institutionen för klinisk vetenskap, intervention och teknik, Karolinska Institutet, Stockholm, Sverige.
    Näring för god vård och omsorg: en vägledning för att förebygga och behandla undernäring2011Report (Other academic)
  • 682.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences. Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Boström, Anne-Marie
    Inst. NVS, sektionen för omvårdnad, Karolinska Institutet, Stockholm, Sverige.
    Krachler, Benno
    Medicinkliniken, Kalix sjukhus, Kalix, Sverige.
    Orrevall, Ylva
    Dietistkliniken, Karolinska Universitetssjukhuset, Huddinge, Sverige.
    Rundgren, Åke
    Enheten för geriatrik Sahlgrenska akademin, Göteborgs universitet, Göteborg, Sverige.
    Sahlin, Nils-Eric
    Avd. för medicinsk etik, Lunds universitet, Lund, Sverige.
    Gyllensvärd, Harald
    Statens beredning för medicinsk utvärdering, Stockholm, Sverige.
    Kosttillägg för undernärda äldre: en systematisk litteraturöversikt.2014Report (Other academic)
  • 683.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Cederholm, T.
    Treatment of protein-energy malnutrition in chronic nonmalignant disorders2001In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 74, no 1, p. 6-24Article in journal (Refereed)
    Abstract [en]

    Protein-energy malnutrition (PEM) is common in connection with chronic disease and is associated with increased morbidity and mortality. Because the risk of PEM is related to the degree of illness, the causal connections between malnutrition and a poorer prognosis are complex. It cannot automatically be inferred that nutritional support will improve the clinical course of patients with wasting disorders. We reviewed studies of the treatment of PEM in cases of chronic obstructive pulmonary disease, chronic heart failure, stroke, dementia, rehabilitation after hip fracture, chronic renal failure, rheumatoid arthritis, and multiple disorders in the elderly. Several methodologic problems are associated with nutrition treatment studies in chronically ill patients. These problems include no generally accepted definition of PEM, uncertain patient compliance with supplementation, and a wide range of outcome variables. Avail-able treatment studies indicate that dietary supplements, either alone or in combination with hormonal treatment, may have positive effects when given to patients with manifest PEM or to patients at risk of developing PEM. In chronic obstructive pulmonary disease, nutritional treatment may improve respiratory function. Nutritional therapy of elderly women after hip fractures may speed up the rehabilitation process. When administered to elderly patients with multiple disorders, diet therapy may improve functional capacity. The data regarding nutritional treatment of the conditions mentioned above is still inconclusive. There is still a great need for randomized controlled long-term studies of the effects of defined nutritional intervention programs in chronically ill and frail elderly with a focus on determining clinically relevant outcomes.

  • 684.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Ellegård, Lars
    Göteborgs universitet, Göteborg, Sverige.
    Klinisk nutrition bör återinföras som medicinsk specialitet2011In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 108, p. 1770-1770Article in journal (Other academic)
  • 685.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Engelheart, Stina
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Inventering av Björkhaga servicehus i Hällefors våren 2010: mat-måltider-hälsotillstånd2010Report (Other academic)
  • 686.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Engelheart, Stina
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Inventering av särskilt boende Backagården i Örebro kommun hösten 2010: Mat – måltider – hälsotillstånd2011Report (Other academic)
  • 687.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Engelheart, Stina
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Vanligt att kommunalt bistånd till äldre rör nutrition2013In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 110, p. CHUE-Article in journal (Other academic)
  • 688.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Flöistrup, H.
    Individual assessment of intake of energy, nutrients and water in 54 elderly multidiseased nursing-home residents2003In: The Journal of Nutrition, Health & Aging, ISSN 1279-7707, E-ISSN 1760-4788, Vol. 7, no 1, p. 1-12Article in journal (Refereed)
    Abstract [en]

    PURPOSE: Examination of the individual intake of energy, nutrients and water in clinically stable multidiseased nursing-home residents.

    METHODS: Comprehensive clinical assessment of 54 elderly nursing-home residents (80 +/- 10 years, mean +/- SD). The intake of food and beverages was measured by the weighed food intake method during five consecutive week days followed by computerized transformation to energy, 21 different nutrients, dietary fiber, alcohol and water. The resting energy expenditure was determined by indirect calorimetry.

    RESULTS: There was at least 2-3-fold, variation in intake of energy, nutrients and water, present also when expressed per kg body weight. For some micronutrients the relative intake variation was more than 8-fold. The results are compared with the present swedish recommended dietary allowances as well as with seven other studies of dietary intake in elderly using the weighed food intake method. The residents had on average 14.1 (range 6-31) different current clinical problems and were treated with a mean of 9.5 different drugs. The nursing staff spent 40 % of the total daytime working hours (7 am to 7 pm) on nutrition related issues.

    CONCLUSIONS: The nursing-home residents exhibited a large interindividual heterogeneity regarding intake of energy, nutrients and water. More emphasis should be given to individualized nutrition assessment in clinical geriatric care as a more solid base for nutrition treatment programmes integrated with the regular medical management and evaluation.

  • 689.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Gustafson, Yngve
    Avd. för geriatrik, Umeå Universitet, Umeå, Sverige.
    Geriatriken behöver skifta fokus: från sjukdom till person2014In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 104, no 31-32, p. 1290-1290, article id CYICArticle in journal (Other (popular science, discussion, etc.))
  • 690.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Gustafson, Yngve
    Umeå University, Umeå, Sweden.
    Personalized Geriatric Medicine2014In: European Geriatric Medicine, ISSN 1878-7649, E-ISSN 1878-7657, Vol. 5, p. 145-146Article in journal (Refereed)
  • 691.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Gustavson, K. H.
    Håkansson, E.
    Sääf, J.
    Kiessling, H.
    Yuwiler, A.
    Wetterberg, L.
    Chromosomal aberrations in a patient with severe psychopathology1992In: British Journal of Psychiatry, ISSN 0007-1250, E-ISSN 1472-1465, Vol. 161, p. 551-555Article in journal (Refereed)
    Abstract [en]

    The case of a female patient showing aggressive, compulsive, destructive behaviour, ritualistic faecal smearing, and hyperactivity is presented. The behaviour is long standing, therapy-resistant, and its aetiology is unknown, although it is seemingly associated with chromosomal abnormalities secondary to abnormal plasma factors.

  • 692.
    Akner, Gunnar
    et al.
    Linnéuniversitetet, Kalmar, Sweden.
    Järhult, Bengt
    Ekonomiska incitament ska inte kopplas till den enskilde patienten2016In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 113, article id D4TPArticle in journal (Refereed)
  • 693.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Lammes, Eva
    Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Rydwik, Elisabeh
    Karolinska Institutet, Stockholm, Sweden.
    Engelheart, Stina
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Rapport från en enkätstudie kring näringsfrågor och fysisk aktivitet till alla personer över 75 år i Solna Stad sommaren 20022002Report (Other academic)
  • 694.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Ljunggren, J. G.
    Kjellman, B. F.
    Undén, F.
    Wetterberg, L.
    Adrenocorticotropin and cortisol response to lysine vasopressin in relation to the outcome of the dexamethasone suppression test in major depressive disorder1988In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 77, no 4, p. 404-410Article in journal (Refereed)
    Abstract [en]

    The pathophysiology behind the abnormalities of the hypothalamic pituitary adrenal cortex axis found in patients with major depressive disorder was studied by the use of the vasopressin test. The response of plasma adrenocorticotropin (ACTH) and cortisol to the injection of 10 IU lysine-vasopressin (LVP) was investigated in 18 patients meeting the DSM-III criteria for major depressive episode. The response was correlated to the outcome of the dexamethasone suppression test (DST) with the use of two different cut-off points, 139 nmol/l and 200 nmol/l respectively. The results show that no significant difference was found in ACTH or cortisol response between patients having a normal or abnormal DST. The results do not seem to support the hypothesis that the abnormalities of the hypothalamic pituitary adrenal cortex axis involve a hypersecretion of corticotropin-releasing factor (CRF) and a subsequent desensitization of the corticotrophs to CRF-stimulated ACTH release.

  • 695.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Mossberg, K.
    Sundqvist, K. G.
    Gustafsson, J. A.
    Wikström, A. C.
    Evidence for reversible, non-microtubule and non-microfilament-dependent nuclear translocation of hsp90 after heat shock in human fibroblasts1992In: European Journal of Cell Biology, ISSN 0171-9335, E-ISSN 1618-1298, Vol. 58, no 2, p. 356-364Article in journal (Refereed)
    Abstract [en]

    A monoclonal antibody (29A) directed against rat liver heat shock protein M(r) 90,000 (hsp90) was produced. By Western immunoblotting of cytosols prepared from several different tissues and species, 29A was shown to specifically recognize only one band with M(r) approximately 90,000. Localization of hsp90 in human gingival fibroblasts was studied using the 29A antibody by indirect mono- and double-staining immunofluorescence and confocal laser scanning microscopy. The distribution was compared to that of the glucocorticoid receptor (GR) and various cytoskeletal structures. Cells were analyzed in interphase and mitosis under basal culture conditions, after heat shock and after microtubule and microfilament depolymerization, sometimes combined with heat shock. A major part of hsp90 immunoreactivity was diffusely distributed throughout the interphase cytoplasm, but a weak nuclear staining with non-stained nucleoli was also present, however, only detectable after methanol and not after formaldehyde/Triton X-100 fixation. Heat shock induced a time-dependent translocation of hsp90 from the cytoplasm to the cell nucleus reaching a plateau after 15 h. This compartment shift was reversible and also occurred in the absence of intact microtubules or intact microfilaments.

  • 696.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Mossberg, K.
    Wikström, A. C.
    Sundqvist, K. G.
    Gustafsson, J. A.
    Evidence for colocalization of glucocorticoid receptor with cytoplasmic microtubules in human gingival fibroblasts, using two different monoclonal anti-GR antibodies, confocal laser scanning microscopy and image analysis1991In: Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, E-ISSN 1879-1220, Vol. 39, no 4A, p. 419-432Article in journal (Refereed)
    Abstract [en]

    The cellular distribution of the glucocorticoid receptor (GR) in relation to the microtubule protein tubulin was studied in human gingival fibroblasts, using two different anti-GR antibodies of different Ig-classes, by indirect immunofluorescence immunocytology. Further studies were performed by confocal laser scanning microscopy and digital image analysis. The study focused on fluorochrome separation, optical sectioning, digital subtraction techniques and reconstruction of projections obtained using stacks of recorded transversal sections. The data presented further strengthens the notion of a structural colocalization between GR and cytoplasmic microtubules in human fibroblasts.

  • 697.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Rothenberg, Elisabet
    Högskolan i Kristianstad, Kristianstad, Sverige.
    Multisjuka och bräckliga äldre2015In: Mat och hälsa: En klinisk handbok / [ed] Tommy Cederholm, Elisabet Rothenberg, Stockholm: Studentlitteratur AB, 2015, 1, p. 105-108Chapter in book (Other academic)
  • 698.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Rundgren, Åke
    Göteborg Universitet, Göteborg, Sverige.
    Gustafson, Yngve
    Umeå universitet, Umeå, Sverige.
    Inrätta ett geriatriskt centrum som utvecklar vården2012In: Dagens medicin, ISSN 1104-7488, no 8, p. 18-19Article in journal (Other (popular science, discussion, etc.))
  • 699.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Rössner, S.
    Intramuscular ceruletide does not affect food intake in obese and non-obese human subjects1985In: Appetite, ISSN 0195-6663, E-ISSN 1095-8304, Vol. 6, no 1, p. 21-24Article in journal (Refereed)
    Abstract [en]

    Intramuscular ceruletide or placebo was given in a randomized double-blind crossover design to 12 non-obese and 12 obese individuals, 30 min before a palatable lunch meal. No significant effects were found on the amount of food intake or the hunger ratings in any group. Although rapid CCK or ceruletide infusions have been found in some studies to reduce food intake in man and animals, slow infusions have increased food intake. Under the present study conditions, the moderate rate of release of ceruletide from intramuscular depots did not affect the food intake.

  • 700.
    Akner, Gunnar
    et al.
    Örebro University, School of Health and Medical Sciences.
    Sundqvist, K. G.
    Denis, M.
    Wikström, A. C.
    Gustafsson, J. A.
    Immunocytochemical localization of glucocorticoid receptor in human gingival fibroblasts and evidence for a colocalization of glucocorticoid receptor with cytoplasmic microtubules1990In: European Journal of Cell Biology, ISSN 0171-9335, E-ISSN 1618-1298, Vol. 53, no 2, p. 390-401Article in journal (Refereed)
    Abstract [en]

    The cellular distribution of the glucocorticoid receptor (GR) in relation to various intracellular and plasma membrane structures in human fibroblasts was studied using indirect immunofluorescence techniques with monoclonal and polyclonal antibodies. During interphase, GR was located predominantly in the cytoplasm, showing a similar pattern as tubulin. In mitotic cells, GR and tubulin were localized in mitotic spindles and in telophase midbodies. Colchicine and vinblastine induced a similar redistribution of GR and tubulin to the cell periphery. This redistribution was reversible for colchicine but not for vinblastine. Vinblastine also induced paracrystals containing GR and tubulin. These results support the hypothesis that GR interacts in vivo with cytoplasmic microtubules.

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