A national multidisciplinary working group was assigned by the Swedish Association of Local Authorities and Regions to create a person-centered clinical pathway for sepsis in adults. This clinical pathway has been approved for implementation in the Swedish healthcare system. It focuses on three interventions: a sepsis alert for patients with instable vital signs and suspected sepsis in the emergency department, the correct discharge coding of sepsis according to ICD-10 codes, and a structured patient follow-up after hospital discharge. Quality indicators will be registered and monitored electronically. A health-economic analysis indicates that the clinical pathway will not drive additional costs for the healthcare system.