Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primatesDiabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Immerge BioTherapeutics, Inc., Massachusetts, USA.
Immerge BioTherapeutics, Inc., Massachusetts, USA.
Immerge BioTherapeutics, Inc., Massachusetts, USA.
Department of Anesthesia, University of Colorado Health Sciences Center, Denver, Colorado, USA.
Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA.
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA.
Department of Veterinary Population Medicine, Veterinary Medical Center, University of Minnesota, St. Paul, Minnesota, USA.
Immerge BioTherapeutics, Inc., Massachusetts, USA.
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2006 (engelsk)Inngår i: Nature Medicine, ISSN 1078-8956, E-ISSN 1546-170X, Vol. 12, nr 3, s. 301-303Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]
Cell-based diabetes therapy requires an abundant cell source. Here, we report reversal of diabetes for more than 100 d in cynomolgus macaques after intraportal transplantation of cultured islets from genetically unmodified pigs without Gal-specific antibody manipulation. Immunotherapy with CD25-specific and CD154-specific monoclonal antibodies, FTY720 (or tacrolimus), everolimus and leflunomide suppressed indirect activation of T cells, elicitation of non-Gal pig-specific IgG antibody, intragraft expression of proinflammatory cytokines and invasion of infiltrating mononuclear cells into islets.
sted, utgiver, år, opplag, sider
Nature Publishing Group, 2006. Vol. 12, nr 3, s. 301-303
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-111605DOI: 10.1038/nm1369ISI: 000235802900027PubMedID: 16491083Scopus ID: 2-s2.0-33644831338OAI: oai:DiVA.org:oru-111605DiVA, id: diva2:1837994
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