Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil)Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, PA 16802, United States.
The J. Craig Venter Institute, Rockville, MD 20850, United States.
The J. Craig Venter Institute, Rockville, MD 20850, United States.
454 Life Sciences, Branford, CT 06405, United States.
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, PA 16802, United States.
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, PA 16802, United States.
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, PA 16802, United States.
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, PA 16802, United States.
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, PA 16802, United States.
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, PA 16802, United States.
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, PA 16802, United States.
Children's Cancer Institute Australia and University of New South Wales, Lowy Cancer Research Centre, Randwick, NSW 2031, Australia.
Children's Cancer Institute Australia and University of New South Wales, Lowy Cancer Research Centre, Randwick, NSW 2031, Australia.
Children's Cancer Institute Australia and University of New South Wales, Lowy Cancer Research Centre, Randwick, NSW 2031, Australia.
Center for Zoo and Wild Animal Health, Copenhagen Zoo, 2000 Frederiksberg, Denmark.
Museum and Art Gallery of the Northern Territory, Darwin 0801, Australia.
Department of Primary Industries and Water, Mt. Pleasant Animal Health Laboratories, Kings Meadows, Tasmania 7249, Australia.
National Museum of Natural History, Smithsonian Institution, Washington, DC 20013-7012, United States.
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, PA 16802, United States.
The Sperling Foundation, Eugene, OR 97405, United States.
Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge Center, Cambridge, MA 02142, United States.
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, PA 16802, United States.
University of Tasmania, Hobart, TAS 7001, Australia.
University of Tasmania, Hobart, TAS 7001, Australia; Immunology, Menzies Research Institute, Hobart, Tasmania 7000, Australia.
University of Tasmania, Hobart, TAS 7001, Australia.
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, University Park, PA 16802, United States.
Vise andre og tillknytning
2011 (engelsk)Inngår i: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 108, nr 30, s. 12348-12353Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]
The Tasmanian devil (Sarcophilus harrisii) is threatened with extinction because of a contagious cancer known as Devil Facial Tumor Disease. The inability to mount an immune response and to reject these tumors might be caused by a lack of genetic diversity within a dwindling population. Here we report a whole-genome analysis of two animals originating from extreme northwest and southeast Tasmania, the maximal geographic spread, together with the genome from a tumor taken from one of them. A 3.3-Gb de novo assembly of the sequence data from two complementary next-generation sequencing platforms was used to identify 1 million polymorphic genomic positions, roughly one-quarter of the number observed between two genetically distant human genomes. Analysis of 14 complete mitochondrial genomes from current and museum specimens, as well as mitochondrial and nuclear SNP markers in 175 animals, suggests that the observed low genetic diversity in today's population preceded the Devil Facial Tumor Disease disease outbreak by at least 100 y. Using a genetically characterized breeding stock based on the genome sequence will enable preservation of the extant genetic diversity in future Tasmanian devil populations.
sted, utgiver, år, opplag, sider
Proceedings of the National Academy of Sciences (PNAS), 2011. Vol. 108, nr 30, s. 12348-12353
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-118779DOI: 10.1073/pnas.1102838108ISI: 000293129900035PubMedID: 21709235Scopus ID: 2-s2.0-79961044560OAI: oai:DiVA.org:oru-118779DiVA, id: diva2:1930109
Forskningsfinansiär
NIH (National Institutes of Health), R01-GM077117
Merknad
Erratum in Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18625. https://doi.org/10.1073/pnas.1217345109
Funding Agencies:
Gordon and Betty Moore Foundation
GENEWORKS, Australia
Allco Foundation, Sydney
United States Department of Health & Human Services
National Institutes of Health (NIH) - USA
NIH National Institute of General Medical Sciences (NIGMS)
Roche Holding
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