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Alcohol use disorder in socially stable women receiving outpatient treatment: Individual characteristics of importance for onset age and treatment outcome
Örebro universitet, Institutionen för medicinska vetenskaper.
2020 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Socially stable women with alcohol use disorder (AUD) are seldom studied separately and are often marginalized in treatment of substance abuse. The overall aim of this thesis was to examine variables of importance in relation to age at onset of AUD and treatment outcome.

Study I, which included 338 men and women being treated for AUD, showed that women had a significantly later onset and shorter duration in excessive alcohol use as well as less weekly pure alcohol intake than men. Participants with earlier onset of excessive alcohol use reported significantly more psychiatric symptoms and more immature personality traits than those with later onset. 

Study II-IV included 75 women with AUD receiving outpatient treatment. Of the participants, 68% reported a history of childhood maltreatment. Emotional abuse and their mother’s alcohol and/or substance problems were independent predictors of earlier age at onset of AUD. In Study III treatment outcome was measured as a change in alcohol consumption. A more positive change, especially with regard to abstinence, was found in women who did not report childhood abuse. Study IV showed that, at 12month follow up, most of the participants had reached their end-oftreatment goal either abstinence or low-risk drinking. However, those with a goal of abstinence at the end of treatment showed significantly less risk drinking than those with low-risk drinking as a goal. The most important predictor of abstinence at the 12-month follow up was having abstinence as an end –of –treatment goal. 

These results indicate the importance of identifying and addressing childhood trauma in treating socially stable women with AUD. Focusing on motivational changes during treatment may also be of importance, especially in patients with relapses, as abstinence still is the most stable treatment option.

Ort, förlag, år, upplaga, sidor
Örebro: Örebro University , 2020. , s. 84
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 223
Nyckelord [en]
AUD, women, childhood maltreatment, onset age, treatment outcome, goal of treatment
Nationell ämneskategori
Allmänmedicin
Identifikatorer
URN: urn:nbn:se:oru:diva-85257ISBN: 978-91-7529-355-4 (tryckt)OAI: oai:DiVA.org:oru-85257DiVA, id: diva2:1462670
Disputation
2020-11-12, Örebro universitet, Campus USÖ, hörsal C1, Södra Grev Rosengatan 32, Örebro, 13:00 (Svenska)
Opponent
Handledare
Tillgänglig från: 2020-08-31 Skapad: 2020-08-31 Senast uppdaterad: 2020-10-22Bibliografiskt granskad
Delarbeten
1. The Importance of Age at Onset of Excessive Alcohol Use with Regard to Psychiatric Symptoms and Personality Characteristics
Öppna denna publikation i ny flik eller fönster >>The Importance of Age at Onset of Excessive Alcohol Use with Regard to Psychiatric Symptoms and Personality Characteristics
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2017 (Engelska)Ingår i: Alcoholism Treatment Quarterly, ISSN 0734-7324, E-ISSN 1544-4538, Vol. 35, nr 4, s. 328-343Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Psychiatric symptoms and personality characteristics were studied in men (n=252) and women (n=86) as they commenced treatment for excessive alcohol use. The Addiction Severity Index, Symptom Check List, and Temperament and Character Inventory were used. ANOVA with early/late onset and gender as covariates showed significantly lower scores for psychiatric symptoms and more mature personality characteristics in the late-onset group compared to early onset. Men described more depression and anxiety, and women higher persistence. Results indicate the importance of considering age at onset of excessive alcohol use when patients enter treatment because different treatment approaches may be required.

Ort, förlag, år, upplaga, sidor
Taylor & Francis Group, 2017
Nyckelord
alcohol onset, gender, personality, psychiatric symptoms
Nationell ämneskategori
Beroendelära och missbruk
Identifikatorer
urn:nbn:se:oru:diva-61355 (URN)10.1080/07347324.2017.1350540 (DOI)000411473600003 ()2-s2.0-85026532744 (Scopus ID)
Anmärkning

Funding Agency:

University Health Care Research Center, Region Örebro County, Sweden 

Tillgänglig från: 2017-10-09 Skapad: 2017-10-09 Senast uppdaterad: 2025-02-11Bibliografiskt granskad
2. The Impact of Childhood Maltreatment on Age of Onset of Alcohol Use Disorder in Women
Öppna denna publikation i ny flik eller fönster >>The Impact of Childhood Maltreatment on Age of Onset of Alcohol Use Disorder in Women
2018 (Engelska)Ingår i: European Addiction Research, ISSN 1022-6877, E-ISSN 1421-9891, Vol. 24, nr 6, s. 278-285Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

It is unclear whether exposure to childhood maltreatment is associated with the age of onset of alcohol use disorder (AUD). A group of socially stable women with AUD seeking treatment (n = 75) were interviewed using the Addiction Severity Index and the Mini International Neuropsychiatric Interview. They also filled out the Childhood Trauma Questionnaire-short form. Emotional abuse, sexual abuse and multiple childhood traumas were found to be associated with earlier onset of AUD. Multivariable linear regression analysis showed that independent predictors for an earlier onset of AUD were exposure to emotional abuse (beta = -7.44, SE = 2.83, adjusted p = 0.010) and mother's alcohol/substance problems (beta = -7.87, SE = 3.45, adjusted p = 0.026). These variables explained 18.9% of the variance of age of onset of AUD. These findings highlight a need for increased clinical attention to AUD subgroups who have experienced childhood maltreatment, especially emotional abuse, as well as a need for including support in the patient's own parental role in the treatment.

Ort, förlag, år, upplaga, sidor
S. Karger, 2018
Nyckelord
Age of onset, Alcohol use disorder, Childhood maltreatment, Mother’s alcohol/substance problems
Nationell ämneskategori
Psykiatri
Forskningsämne
Psykiatri
Identifikatorer
urn:nbn:se:oru:diva-72004 (URN)10.1159/000494766 (DOI)000456650200002 ()30448841 (PubMedID)2-s2.0-85057010272 (Scopus ID)
Anmärkning

Funding Agency:

University Health Care Research Center, Region Örebro County, Sweden

Tillgänglig från: 2019-02-01 Skapad: 2019-02-01 Senast uppdaterad: 2021-11-22Bibliografiskt granskad
3. History of childhood abuse is associated with less positive treatment outcomes in socially stable women with alcohol use disorder
Öppna denna publikation i ny flik eller fönster >>History of childhood abuse is associated with less positive treatment outcomes in socially stable women with alcohol use disorder
2019 (Engelska)Ingår i: BMC Women's Health, E-ISSN 1472-6874, Vol. 19, nr 1, artikel-id 159Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: To examine the relationship between treatment outcome, as measured according to change in alcohol consumption, and a history of childhood abuse (emotional, physical, sexual) in socially stable women undergoing treatment for alcohol use disorder (AUD).

Methods: Participants were assessed using the Addiction Severity Index and the Mini International Neuropsychiatric Interview at the beginning of treatment (n = 75), end of treatment (n = 59) and 12 month follow-up after treatment (n = 57). Self-report data on alcohol consumption were obtained at all three time-points using the Alcohol Habits Inventory-Revised 2. Self-report data on childhood maltreatment were obtained at the beginning of treatment using the Childhood Trauma Questionnaire-short form. Study outcomes were changes in alcohol consumption (grams of pure alcohol per week), risk-drinking and reported abstinence.

Results: Of the 75 women enrolled, 38 (50.7%) reported a history of childhood abuse and the rest did not. Both groups showed a significant improvement in all three outcomes at the end of treatment and at 12-month follow-up. At the end of treatment, a significant inter-group difference was found for reported abstinence (non-abused group, 39.3% vs abused, 12.9%; p < 0.05). At 12-month follow-up, significant inter-group differences were observed for all treatment outcomes, with superior outcomes being found for the non-abused group, including a higher proportion of women with reported abstinence (55.6% vs 13.3%; p < 0.01).

Conclusion: The present findings suggest that an evaluation of a possible history of childhood abuse is warranted in all women seeking treatment for AUD, irrespective of social stability. In terms of clinical practice, the results suggest that additional interventions may be warranted in this population.

Ort, förlag, år, upplaga, sidor
BMC, 2019
Nyckelord
Adult women, Alcohol use disorder, Childhood abuse, Treatment outcome
Nationell ämneskategori
Folkhälsovetenskap, global hälsa och socialmedicin
Identifikatorer
urn:nbn:se:oru:diva-79099 (URN)10.1186/s12905-019-0857-4 (DOI)000502718200002 ()31830964 (PubMedID)2-s2.0-85076488310 (Scopus ID)
Anmärkning

Funding Agency:

University Health Care Research Center, Region Örebro County, Sweden

Tillgänglig från: 2020-01-15 Skapad: 2020-01-15 Senast uppdaterad: 2025-02-20Bibliografiskt granskad
4. Predictors for abstinence at 12-month follow up in socially stable women seeking treatment for alcohol use disorder
Öppna denna publikation i ny flik eller fönster >>Predictors for abstinence at 12-month follow up in socially stable women seeking treatment for alcohol use disorder
(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Nationell ämneskategori
Allmänmedicin
Identifikatorer
urn:nbn:se:oru:diva-86674 (URN)
Tillgänglig från: 2020-10-20 Skapad: 2020-10-20 Senast uppdaterad: 2020-12-01Bibliografiskt granskad

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