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Revisional bariatric surgery: more than a moral obligation
Örebro universitet, Institutionen för medicinska vetenskaper.
2022 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Growing awareness of biological, genetic, environmental, and behavioural factors contributed to the recognition of obesity as a chronic disease. Nowadays, obesity and its medical/surgical treatment is widely acknowledgedin the medical curriculum. Bariatric surgery has long been shown to provide superior induction and maintenance of weight loss, together with improvement or resolution of obesity-related diseases. The role of revisional bariatric surgery for treatment of procedure-related complications is accepted. However, its role as second-line treatment of patients with primary or secondary non-response is still a matter of debate. This prompted Dr Henry Buchwald in 2015 to publish his article “Revisional Metabolic/Bariatric Surgery: A Moral Obligation”. 

Studies I and II in this doctoral thesis covered issues that fuel the ongoing controversy, namely effects and risks of revisional surgery. Conversion to gastric bypass is the most common revisional procedure in Sweden. In Studies I and II, we found revisional gastric bypass to give inferior weight loss with a higher risk for perioperative complications compared to primary gastric bypass. However, the beneficial effects on obesity-related disease were similar (Papers I and II). In Study III, the theoretical need for revisional bariatric surgery in patients with primary or secondary weight non-response was evaluated. When applying four different indication criteria, more than 13% of patients met the criteria for second-line treatment, with a significant higher probability after sleeve gastrectomy compared to gastric bypass (Paper III). To gain a clearer picture, a systematic review of the literature on revisional bariatric surgery after sleeve gastrectomy was inevitable. However, an evidence-based treatment strategy for patients with primary or secondary weight non-response could not be deduced from the current literature (Paper IV).

Ort, förlag, år, upplaga, sidor
Örebro: Örebro University , 2022. , s. 81
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 265
Nyckelord [en]
Obesity, bariatric surgery, revisional surgery, sleeve gastrectomy, gastric bypass
Nationell ämneskategori
Kirurgi
Identifikatorer
URN: urn:nbn:se:oru:diva-98514ISBN: 9789175294469 (tryckt)OAI: oai:DiVA.org:oru-98514DiVA, id: diva2:1650744
Disputation
2022-06-09, Örebro universitet, Campus USÖ, hörsal C1, Södra Grev Rosengatan 32, Örebro, 09:00
Opponent
Handledare
Tillgänglig från: 2022-04-08 Skapad: 2022-04-08 Senast uppdaterad: 2022-05-11Bibliografiskt granskad
Delarbeten
1. Weight loss and alterations in co-morbidities after revisional gastric bypass: A case-matched study from the Scandinavian Obesity Surgery Registry
Öppna denna publikation i ny flik eller fönster >>Weight loss and alterations in co-morbidities after revisional gastric bypass: A case-matched study from the Scandinavian Obesity Surgery Registry
2017 (Engelska)Ingår i: Surgery for Obesity and Related Diseases, ISSN 1550-7289, E-ISSN 1878-7533, Vol. 13, nr 5, s. 796-800Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: In Sweden, Roux-en-Y gastric bypass is the most common procedure when revising a previous bariatric procedure. This study is an analysis of all revisional gastric bypass operations (rGBP) compared with a matched group of primary gastric bypass (pGBP) operated between 2007 and 2012.

Objective: The aim was to determine whether improvement of obesity-related co-morbidity and changes in weight after revisional gastric bypass surgery were comparable with those seen after primary surgery.

Setting: 44 hospitals in Sweden

Methods: Retrospective data were retrieved from the Scandinavian Obesity Surgery Registry. The study group (rGBP) comprised 1224 patients, and the control group (pGBP) comprised 3612 patients matched for age and gender.

Results: The indication for revision was weight failure in 512 patients (42%), a late complication of the initial procedure in 330 patients (27%), and a combination of weight failure and complication in 303 patients (25%). A total of 66% of patients in the rGBP group and 67% in the pGBP group completed the 2-year follow-up in the Scandinavian Obesity Surgery Registry.

The rGBP-group had significantly less excess BMI loss (%EBMIL, 59.4 +/- 147.0 versus 79.5 +/- 24.7, P < .001) and a lower dyslipidemia remission rate (42.9% versus 62.0%, P = .005) at the time of the 2-year follow-up. Remission rates of sleep apnea, hypertension, type 2 diabetes, and depression were similar. The effects on obesity-related co-morbidity were not related to the indication for revisional surgery or the initial bariatric procedure.

Conclusion: Even if weight results might be inferior compared with primary bypass procedures, the improvement of co-morbidity is similar. (C) 2017 American Society for Metabolic and Bariatric Surgery. All right reserved

Ort, förlag, år, upplaga, sidor
Elsevier, 2017
Nyckelord
Revision, Gastric bypass, Weight loss, Diabetes, Co-morbidities, Bariatric surgery
Nationell ämneskategori
Kirurgi
Forskningsämne
Kirurgi
Identifikatorer
urn:nbn:se:oru:diva-58961 (URN)10.1016/j.soard.2017.01.030 (DOI)000404829600011 ()28233688 (PubMedID)2-s2.0-85013220042 (Scopus ID)
Anmärkning

Funding Agency:

Landstinget i Värmland Sweden 

Tillgänglig från: 2017-08-04 Skapad: 2017-08-04 Senast uppdaterad: 2022-05-11Bibliografiskt granskad
2. Predictive factors of complications in revisional gastric bypass surgery: results from the Scandinavian Obesity Surgery Registry
Öppna denna publikation i ny flik eller fönster >>Predictive factors of complications in revisional gastric bypass surgery: results from the Scandinavian Obesity Surgery Registry
2019 (Engelska)Ingår i: Surgery for Obesity and Related Diseases, ISSN 1550-7289, E-ISSN 1878-7533, Vol. 15, nr 12, s. 2094-2100Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Roux-en-Y gastric bypass is the most common procedure for revisional bariatric surgery. This study is an analysis of revisional gastric bypass operations (rGBP) compared with primary gastric bypass (pGBP) performed in Sweden between 2007 and 2016.

Objective: The aim was to compare the incidence of adverse events in primary and revisional gastric bypass surgery and to identify predictive factors of intraoperative, early, and late complications in revisional gastric bypass surgery.

Setting: Forty-four hospitals.

Methods: Registered study from the Scandinavian Obesity Surgery Registry. The study group (rGBP) comprised 1795 patients, and the control group (pGBP) comprised 46,055 patients.

Results: Median follow-up time was 28 months. The rate of open procedures was significantly higher in the rGBP group (39.1% versus 2.4%; P < .001) decreasing from 70.8% in 2007 to 8.5% in 2016. Intraoperative complications (15.5% versus 3.0%, P < .001), early complications (24.6% versus 8.7%; P < .001), and late complications (17.7% versus 8.7%; P < .001) occurred more often in the rGBP group. Open access in revisional surgery was an independent risk factor for intraoperative complications (odds ratio 3.87; 95% confidence interval: 2.69-5.57, P < .001), early complications (odds ratio 2.08; 95% confidence interval: 1.53-2.83, P < .001), and late complications (odds ratio 1.91; 95% confidence interval: 1.31-2.78, P = .001). Indication for revision or type of index operation were not associated with complications.

Conclusion: RGBP was associated with a higher incidence of intraoperative, early, and late complications compared with pGBP. Open access in revisional surgery was predictive of complications regardless of the index operation or indication for revision.

Ort, förlag, år, upplaga, sidor
Elsevier, 2019
Nyckelord
Revision, Gastric bypass, Predictive factors, Complications, Bariatric surgery
Nationell ämneskategori
Kirurgi
Identifikatorer
urn:nbn:se:oru:diva-79110 (URN)10.1016/j.soard.2019.09.071 (DOI)000504368600012 ()31640905 (PubMedID)2-s2.0-85073751563 (Scopus ID)
Anmärkning

Funding Agency:

Region Värmland Sweden

Tillgänglig från: 2020-01-15 Skapad: 2020-01-15 Senast uppdaterad: 2022-05-11Bibliografiskt granskad
3. Non-response after gastric bypass and sleeve gastrectomy: The theoretical need for revisional bariatric surgery Results from the Scandinavian Obesity Surgery Registry
Öppna denna publikation i ny flik eller fönster >>Non-response after gastric bypass and sleeve gastrectomy: The theoretical need for revisional bariatric surgery Results from the Scandinavian Obesity Surgery Registry
(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Nationell ämneskategori
Kirurgi
Identifikatorer
urn:nbn:se:oru:diva-98912 (URN)
Tillgänglig från: 2022-05-09 Skapad: 2022-05-09 Senast uppdaterad: 2022-05-09Bibliografiskt granskad
4. Weight-related outcomes after revisional bariatric surgery in patients with primary or secondary non-response after sleeve gastrectomy: a systematic review
Öppna denna publikation i ny flik eller fönster >>Weight-related outcomes after revisional bariatric surgery in patients with primary or secondary non-response after sleeve gastrectomy: a systematic review
Visa övriga...
(Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
Nationell ämneskategori
Kirurgi
Identifikatorer
urn:nbn:se:oru:diva-98913 (URN)
Tillgänglig från: 2022-05-09 Skapad: 2022-05-09 Senast uppdaterad: 2022-05-09Bibliografiskt granskad

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