Gender inequality is a serious and complex challenge that needs to be addressed by academic managers and leaders, who should ensure that they facilitate increased gender equality with regards to both formal and informal institutional practices. This chapter argues for the importance of gender aware and gender competent academic managers and leaders who are willing to take on the role as change agent for gender equality and exercise gender equality change management and leadership. Explored here are the conditions for such successful change agency for gender equality. The chapter adds to previous research in this area by emphasizing the distinction between formal and informal change strategies, tasks and responsibilities. These distinctions are illustrated with examples from a study on gender mainstreaming in Swedish Higher Education where academic managers were interviewed about their implementation strategies.