B Cell Tolerance and Targeted Therapies in SLE
2023 (Engelska)Ingår i: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 12, nr 19, artikel-id 6268Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]
Systemic Lupus Erythematosus (SLE) is a chronic systemic autoimmune disease of high clinical and molecular heterogeneity, and a relapsing-remitting pattern. The disease is currently without cure and more prevalent in women. B cell tolerance and production of autoantibodies are critical mechanisms that drive SLE pathophysiology. However, how the balance of the immune system is broken and how the innate and adaptive immune systems are interacting during lupus-specific autoimmune responses are still largely unknown. Here, we review the latest knowledge on B cell development, maturation, and central versus peripheral tolerance in connection to SLE and treatment options. We also discuss the regulation of B cells by conventional T cells, granulocytes, and unconventional T cells, and how effector B cells exert their functions in SLE. We also discuss mechanisms of action of B cell-targeted therapies, as well as possible future directions based on current knowledge of B cell biology.
Ort, förlag, år, upplaga, sidor
MDPI, 2023. Vol. 12, nr 19, artikel-id 6268
Nyckelord [en]
B cell tolerance, NKT cells, SLE, lupus, neutrophils
Nationell ämneskategori
Klinisk medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-108982DOI: 10.3390/jcm12196268ISI: 001083055400001PubMedID: 37834911Scopus ID: 2-s2.0-85173902800OAI: oai:DiVA.org:oru-108982DiVA, id: diva2:1805074
Forskningsfinansiär
Reumatikerförbundet, R-969696Konung Gustaf V:s Jubileumsfond, FAI-2020-0741Svenska läkaresällskapet, SLS-974449Nyckelfonden, OLL-974804Region Stockholm, FoUI-955483VetenskapsrådetWenner-Gren StiftelsernaKarolinska Institutet
Anmärkning
This research was funded by: the Swedish Rheumatism Association, grant number R-969696; King Gustaf V's 80-year Foundation, grant number FAI-2020-0741; Swedish Society of Medicine, grant number SLS-974449; Nyckelfonden, grant number OLL-974804; Professor Nanna Svartz Foundation, grant number 2021-00436; Ulla and Roland Gustafsson Foundation, grant number 2021-26; Region Stockholm, grant number FoUI-955483; Swedish Research Council; Wennergren Foundation; the National Natural Science Foundation of China, grant number 82003364; the Hunan Provincial Natural Science Foundation of China, grant number 2023JJ40827; the Scientific Research Launch Project for new employees of the Second Xiangya Hospital of Central South University; and Karolinska Institutet.
2023-10-162023-10-162025-02-18Bibliografiskt granskad