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Short term results in a population based study indicate advantage for laparoscopic colon cancer surgery versus open
Department of Surgery, SSORG - Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 416 85, Gothenburg, Sweden; Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
Örebro University, School of Medical Sciences. Department of Surgery, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0003-4939-4189
Örebro University, School of Medical Sciences. Department of Surgery, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0002-6671-7130
School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
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2023 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 13, no 1, article id 4335Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to compare LAP with OPEN regarding short-term mortality, morbidity and completeness of the cancer resection for colon cancer in a routine health care setting using population based register data. All 13,683 patients who were diagnosed 2012-2018 and underwent elective surgery for right-sided or sigmoid colon cancer were included from the Swedish Colorectal Cancer Registry and the National Patient Registry. Primary outcome was 30-day mortality. Secondary outcomes were 90-day mortality, length of hospital stay, reoperation, readmission and positive resection margin (R1). Weighted and unweighted multi regression analyses were performed. There were no difference in 30-day mortality: LAP (0.9%) and OPEN (1.3%) (OR 0.89, 95% CI 0.62-1.29, P = 0.545). The weighted analyses showed an increased 90-day mortality following OPEN, P < 0.001. Re-operations and re-admission were more frequent after OPEN and length of hospital stay was 2.9 days shorter following LAP (P < 0.001). R1 resections were significantly more common in the OPEN group in the unweighted and weighted analysis with P = 0.004 and P < 0.001 respectively. Therefore, the favourable short-term outcomes following elective LAP versus OPEN resection for colon cancer in routine health care indicate an advantage of laparoscopic surgery.

Place, publisher, year, edition, pages
Nature Publishing Group, 2023. Vol. 13, no 1, article id 4335
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Surgery
Identifiers
URN: urn:nbn:se:oru:diva-105108DOI: 10.1038/s41598-023-30448-8ISI: 000984357200029PubMedID: 36927758Scopus ID: 2-s2.0-85150312979OAI: oai:DiVA.org:oru-105108DiVA, id: diva2:1744846
Funder
University of GothenburgSwedish Cancer SocietyAnna-Lisa and Bror Björnsson Foundation
Note

Funding agency:

ALF Sahlgrenska University Hospital, 'Agreement concerning research and education of doctors' ALFGBG-716581

Available from: 2023-03-21 Created: 2023-03-21 Last updated: 2023-12-07Bibliographically approved

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Matthiessen, PeterDehlaghi Jadid, Kaveh

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