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The feasibility of using eye-tracking technology for cognitive screening in Down syndrome with dementia: A cross-sectional case series
Örebro University, School of Health Sciences.ORCID iD: 0000-0002-5567-9431
The Laboratory for Visual Neuroplasticity, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
Örebro University, School of Health Sciences. University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID iD: 0000-0002-6703-7575
2025 (English)In: Alzheimer's & Dementia: Journal of the Alzheimer's Association, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 21, no 6, article id e70385Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Adults with Down syndrome (DS) are at a high risk for dementia, yet cognitive screening is complicated by premorbid intellectual disabilities. This study evaluated the feasibility of using eye-tracking technology as a screening tool.

METHODS: Ten adults with DS (five with dementia, five without) completed cognitive tasks while their eye movements were recorded. Feasibility was assessed through calibration success, gaze sample quality, and task completion.

RESULTS: Calibration was successful for most subjects (except one individual with dementia required five attempts and had low gaze sampling). Most subjects achieved 50%-88% gaze sample rates and completed testing with staff support. Subjects with dementia showed longer times to first fixation but similar fixation durations compared to those without dementia. Cognitive scores were lower in the dementia group but not significantly correlated with gaze quality.

DISCUSSION: Eye tracking may be a feasible method for cognitive screening in DS, but further validation is needed. HIGHLIGHTS: Eye-tracking may be a potential non-verbal method for cognitive screening in individuals with DS. Support from staff for engaging the subjects could be essential for maintaining attention on the computer screen.

Place, publisher, year, edition, pages
John Wiley & Sons, 2025. Vol. 21, no 6, article id e70385
Keywords [en]
Down syndrome, cognition, dementia, eye‐tracking, screening
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:oru:diva-121668DOI: 10.1002/alz.70385ISI: 001519829400005PubMedID: 40524439OAI: oai:DiVA.org:oru-121668DiVA, id: diva2:1971042
Funder
Promobilia foundation, 21027, A23028Region Örebro CountyÖrebro UniversityAvailable from: 2025-06-17 Created: 2025-06-17 Last updated: 2025-07-24Bibliographically approved

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Lindner, Helen YLundqvist, Lars-Olov

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