The purpose of this article is to discuss the role of migration processes to changes in the world-system. We highlight the significanceof these processes and their impact through a comparative historical perspective. By using an approach based on an integrated comparison, two cases are compared: the rise of the early modern Dutch state to hegemony and the corresponding rise to hegemony bythe United States in the twentiethcentury. In presenting secondary sources on the two cases, we argue that neither expansion had been possible without a significant inflow of labor and skills carried by migrants. There seems to be a strong correlation between migration and changes in the world-system in general and the rise to hegemonic status in particular. By analyzing long-term processes like migration and its role in energizing and stimulating changes in the world-system, we argue, in line with the new economics of migration, that previous economic explanations to the rise of hegemony can be qualified. We also argue that the use of integrated comparison in the way we tentatively do in this paper can be fruitful in better understanding historical processes and their impact on power relations and economic relations in the world-system.