Six systematic literature reviews together with meta-analyses have been published on the associations between Alzheimer’s disease and occupational risk factors. Our meta-analyses were based only on studies fulfilling good standards of scientific quality. We scrutinized the 54 relevant original publications found using a checklist proposed by the MOOSE-group together with a new elaborated protocol. Thus our results are not hampered by bias from studies of lower scientific quality. Thirty publications fulfilled good scientific standards and were thus used in our meta-analyses. Exposures to electromagnetic fields were concerned in 12 publications. The weighted relative risk estimate was 1.35 (95% confidence interval: 1.08-1.70). Exposure to pesticides or other chemicals resulted in the statistically significant relative risk 1.5 while exposure to metals involved no increase of risk. A high degree of work complexity (especially in relation to people) and long education were both protective against Alzheimer’s disease. Based on ten studies the weighted relative risk was 0.47 (95% CI: 0.35-0.63). Both work-related risk factors and protective factors are discussed in relation to possible pathophysiological mechanisms.