Respiratory Health and Inflammatory Markers: Exposure to Cobalt in the Swedish Hard Metal IndustryShow others and affiliations
2020 (English)In: Journal of Occupational and Environmental Medicine, ISSN 1076-2752, E-ISSN 1536-5948, Vol. 62, no 10, p. 820-829Article in journal (Refereed) Published
Abstract [en]
OBJECTIVE: To study the relationship between inhalable dust and cobalt and respiratory symptoms, lung function, exhaled nitric oxide in expired air and CC16 in the Swedish hard metal industry.
METHODS: Personal sampling of inhalable dust and cobalt, medical examination including blood sampling was performed for 72 workers. Exposure-response relationships was determined using logistic, linear and mixed model analysis.
RESULTS: The average inhalable dust and cobalt concentrations were 0.079 and 0.0017 mg/m, respectively. Statistically significant increased serum levels of CC16 were determined when the high and low cumulative exposures for cobalt were compared. Non-significant exposure-response relationships was observed between cross-shift inhalable dust or cobalt exposures and asthma, nose dripping and bronchitis.
CONCLUSIONS: Our findings suggest an exposure-response relationship between inhalable cumulative cobalt exposure and CC16 levels in blood, which may reflect an injury or a reparation process in the lungs.
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2020. Vol. 62, no 10, p. 820-829
Keywords [en]
cobalt exposure, hard metal, inflammatory markers, particle exposure, respiratory health
National Category
Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:oru:diva-84765DOI: 10.1097/JOM.0000000000001952ISI: 000618901600018PubMedID: 32769782Scopus ID: 2-s2.0-85092677925OAI: oai:DiVA.org:oru-84765DiVA, id: diva2:1463823
Funder
Knowledge Foundation, 20160044
Note
Funding Agencies:
Örebro University ORU 2.2.1-4060/2013
ALF ALFGBG-872511
2020-09-032020-09-032024-03-05Bibliographically approved