To Örebro University

BACKGROUND: The evidence linking ambient air pollution to bladder cancer is limited and mixed.

METHODS: We assessed the associations of bladder cancer incidence with residential exposure to fine particles (PM_2.5), nitrogen dioxide (NO₂), black carbon (BC), warm season ozone (O₃) and eight PM_2.5 elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) in a pooled cohort (N = 302,493). Exposures were primarily assessed based on 2010 measurements and back-extrapolated to the baseline years. We applied Cox proportional hazard models adjusting for individual- and area-level potential confounders.

RESULTS: During an average of 18.2 years follow-up, 967 bladder cancer cases occurred. We observed a positive though statistically non-significant association between PM_2,5 and bladder cancer incidence. Hazard Ratios (HR) were 1.09 (95% confidence interval (CI): 0.93-1.27) per 5 µg/m³ for 2010 exposure and 1.06 (95% CI: 0.99-1.14) for baseline exposure. Effect estimates for NO₂, BC and O₃ were close to unity. A positive association was observed with PM_2.5 zinc (HR 1.08; 95% CI: 1.00-1.16 per 10 ng/m³).

CONCLUSIONS: We found suggestive evidence of an association between long-term PM_2.5 mass exposure and bladder cancer, strengthening the evidence from the few previous studies. The association with zinc in PM_2.5 suggests the importance of industrial emissions.