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Trends in spasticity-reducing surgery and botulinum toxin treatment for post-stroke spasticity: a register study on 6,258 patients in Sweden, 2010-2021
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Orthopedics and Hand Surgery.ORCID iD: 0000-0002-5083-3591
Department of Diagnostic and Intervention, Hand and Plastic Surgery, Umeå University, Sweden.
Hand Center Malmö, Atleva Specialist Care, Sweden.
Sahlgrenska Osteoporosis Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
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2025 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 57, article id jrm42684Article in journal (Refereed) Published
Abstract [en]

Spasticity is characterized by increased muscle tone, which can result in pain, contractures, impaired hygiene, and deformities. Stroke is a leading cause of paresis, and nearly 40% of stroke patients will develop spasticity.

OBJECTIVE: To assess trends in upper and lower extremity spasticity-reducing surgery and botulinum toxin A (BoNT-A) treatment. DESIGN: A national cohort register study.

METHODS: Upper and lower extremity spasticity-reducing surgery and BoNT-A treatment in Swedish stroke patients over a 12-year period was assessed using the National Patient Register.

RESULTS: A total of 6,258 patients were treated during this period; their mean age was 58, and the majority were male. In both upper and lower extremities, tenotomy was the most common surgical procedure, followed by tendon lengthening. The need for BoNT-A injections was significantly reduced after surgery compared with before surgery. The total number of BoNT-A treatments increased during the study period, and ultrasound guidance of injections became more common.

CONCLUSION: The frequency of BoNT-A treatments was significantly reduced in patients who underwent surgery. Even though no causative association can be established due to the nature of these registry data, this may indicate that surgery reduces the need for further BoNT-A treatments.

Place, publisher, year, edition, pages
Foundation for Rehabilitation Information , 2025. Vol. 57, article id jrm42684
Keywords [en]
Botulinum toxin, spasticity, stroke, tendon transfer, extremity surgery
National Category
Rehabilitation Medicine
Identifiers
URN: urn:nbn:se:oru:diva-120111DOI: 10.2340/jrm.v57.42684ISI: 001460303900001PubMedID: 40099827Scopus ID: 2-s2.0-105001002042OAI: oai:DiVA.org:oru-120111DiVA, id: diva2:1946342
Funder
Promobilia foundation
Note

Fundinga Agencies:

Promobilia, IPSEN, and the Agneta Prytz-Folkes and Gösta Folkes Foundation.

Available from: 2025-03-21 Created: 2025-03-21 Last updated: 2026-01-23Bibliographically approved

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Sagerfors, Marcus

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