Elevated Plasma Levels of NET Components in Men with Severe COVID-19 Correlates to Increased Amounts of IL-18Show others and affiliations
2025 (English)In: European Journal of Immunology, ISSN 0014-2980, E-ISSN 1521-4141, Vol. 55, no 5, article id e202451546Article in journal, Letter (Refereed) Published
Abstract [en]
Severe COVID-19 disease is accompanied by high plasma levels of proinflammatory, prothrombotic NETs, and NET-inducing cytokine IL-18. We found that both, IL-18 and NETs, are elevated in men with severe disease, but not in women of the same category. Our findings warrant further investigation of sex-related differences in SARS-CoV-2 infection.
Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2025. Vol. 55, no 5, article id e202451546
Keywords [en]
COVID‐19, IL‐18, disease severity, neutrophil extracellular traps, sex‐dependent
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:oru:diva-121006DOI: 10.1002/eji.202451546ISI: 001499546100018PubMedID: 40346759Scopus ID: 2-s2.0-105004729034OAI: oai:DiVA.org:oru-121006DiVA, id: diva2:1957605
Funder
Swedish Research Council, 2022-00850Swedish Research Council, 2020-01764Umeå University, 2.1.6-1233-20Region Västerbotten, 941762Region Västerbotten, 981856Region Västerbotten, 996165Stiftelsen Seth M. Kempes Minnes StipendiefondNyckelfonden, OLL-938628Nyckelfonden, OLL-961416Sjukvårdsregionala forskningsrådet Mellansverige, RFR-968856Sjukvårdsregionala forskningsrådet Mellansverige, RFR-940474Science for Life Laboratory, SciLifeLabKnut and Alice Wallenberg FoundationSwedish Heart Lung Foundation, 20200325Swedish Heart Lung Foundation, 202100789Swedish Heart Lung FoundationSwedish Heart Lung Foundation, 20220325
Note
Funding Agencies:
Funding: We acknowledge the following funding: C.F.U. from VR (2022-00850 & 2020-01764), Umeå University (FS 2.1.6-1233-20), and Region Västerbotten (RV) (941762, 981856, 996165); E.B. from J. C. Kempes Minnes Stipendiefond; S.C. from Nyckelfonden Örebro (OLL-938628 & OLL-961416) and Regional Research Council Mid Sweden (RFR-968856 & RFR-940474); C.A. from SciLifeLab, National COVID-19 Research Program (VC-2020-0015) via Knut & Alice Wallenberg Foundation, Swedish Heart-Lung Foundation (20200325, 202100789 & 20220325), Umeå University and RV (938855); M.F. from VR consolidator (2020-06235); A.L. from RV (992412).
2025-05-122025-05-122025-06-10Bibliographically approved