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The pharmacological management of dental pain
NEMA Research Group, Inc, Naples, FL, USA.
Centre for Research and Development, Uppsala/Region, Sweden; Department of Medicine, Cardiology Research Unit, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0001-7906-7782
NEMA Research Group, Inc, Naples, FL, USA.
Anesthesiology, Pain Medicine, and Orthopedics, New York University Langone Health, New York, NY, USA.
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2020 (English)In: Expert Opinion on Pharmacotherapy, ISSN 1465-6566, E-ISSN 1744-7666, Vol. 21, no 5, p. 591-601Article, review/survey (Refereed) Published
Abstract [en]

Introduction:

Dental pain is primarily treated by dentists and emergency medicine clinicians and may occur because of insult to the tooth or oral surgery. The dental impaction pain model (DIPM) has been widely used in clinical studies of analgesic agents and is generalizable to many other forms of pain.

Areas Covered:

The authors discuss the DIPM, which has allowed for important head-to-head studies of analgesic agents, such as acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and combinations. Postsurgical dental pain follows a predictable trajectory over the course of one to 3 days. Dental pain may have odontic origin or may be referred pain from other areas of the body.

Expert opinion:

Pain following oral surgery has sometimes been treated with longer-than-necessary courses of opioid therapy. Postsurgical dental pain may be moderate to severe but typically resolves in a day or two after the extraction. Opioid monotherapy, rarely used in dentistry but combination therapy (opioid plus acetaminophen or an NSAID), was sometimes used as well as nonopioid analgesic monotherapy. The dental impaction pain model has been valuable in the study of analgesics but does not address all painful conditions, for example, pain with a neuropathic component.

Place, publisher, year, edition, pages
Ashley Mark Publishing Company , 2020. Vol. 21, no 5, p. 591-601
Keywords [en]
Analgesia, dental pain, dental pain model, opioids, pain control
National Category
Odontology
Identifiers
URN: urn:nbn:se:oru:diva-122183DOI: 10.1080/14656566.2020.1718651ISI: 000513095800001PubMedID: 32027199Scopus ID: 2-s2.0-85079217239OAI: oai:DiVA.org:oru-122183DiVA, id: diva2:1979494
Available from: 2025-06-30 Created: 2025-06-30 Last updated: 2026-01-23Bibliographically approved

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Magnusson, Peter

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