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An explainable and efficient deep learning framework for EEG-based diagnosis of Alzheimer's disease and frontotemporal dementia
Department of Cybersecurity, Pakistan Navy Engineering College, National University of Sciences and Technology, Karachi, Pakistan.
School of Computing, Engineering and the Built Environment, Edinburgh Napier University, Edinburgh, United Kingdom.
Computer Science Department, College of Computer and Information Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; King Salman Center for Disability Research, Riyadh, Saudi Arabia.
Applied College, University of Tabuk, Tabuk, Saudi Arabia.
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2025 (English)In: Frontiers in Medicine, E-ISSN 2296-858X, Vol. 12, article id 1590201Article in journal (Refereed) Published
Abstract [en]

The early and accurate diagnosis of Alzheimer's Disease and Frontotemporal Dementia remains a critical challenge, particularly with traditional machine learning models which often fail to provide transparency in their predictions, reducing user confidence and treatment effectiveness. To address these limitations, this paper introduces an explainable and lightweight deep learning framework comprising temporal convolutional networks and long short-term memory networks that efficiently classifies Frontotemporal dementia (FTD), Alzheimer's Disease (AD), and healthy controls using electroencephalogram (EEG) data. Feature engineering has been conducted using modified Relative Band Power (RBP) analysis, leveraging six EEG frequency bands extracted through power spectrum density (PSD) calculations. The model achieves high classification accuracies of 99.7% for binary tasks and 80.34% for multi-class classification. Furthermore, to enhance the transparency and interpretability of the framework, SHAP (SHapley Additive exPlanations) has been utilized as an explainable artificial intelligence technique that provides insights into feature contributions.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2025. Vol. 12, article id 1590201
Keywords [en]
explainable AI, XAI, Alzheimer's disease, temporal convolutional networks, long short-term memory, frontotemporal dementia, EEG, mental disorders
National Category
Other Medical Sciences not elsewhere specified Media and Communications
Identifiers
URN: urn:nbn:se:oru:diva-122737DOI: 10.3389/fmed.2025.1590201ISI: 001538747700001PubMedID: 40735445Scopus ID: 2-s2.0-105011989775OAI: oai:DiVA.org:oru-122737DiVA, id: diva2:1989231
Note

The authors extend their appreciation to the King Salman Center For Disability Research for funding this work through Research Group no KSRG-2024-430

Available from: 2025-08-15 Created: 2025-08-15 Last updated: 2026-01-23Bibliographically approved

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Hanif, Muhammad

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